Evaluation of the anti-inflammatory activity of extract of Abrus precatorious

Yıl 2009, Cilt: 14 Sayı: 1, 23 - 25, 14.01.2013

Owunari A. Georgewill Udeme O. Georgewill

Öz

Abstract. The anti-inflammatory activity of the extract of Abrus precatorius was investigated. Inflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat ear. After 6 hrs, cutting out the ear quantitated the response. The cut ear is weighed and the increase in weight relative to controls evaluated. Extract of A. precatorius when co applied with croton oil to the rat ear produced a reduction in the inflammatory response produced when croton oil alone was applied to the rat ear. The extract produced 67.10 + 2% reduction of the inflammatory response produced by croton oil alone, this was however lower than the 71.1 + 2% reduction of the inflammatory response produced by acetyl salicylic acid. This finding suggests that extract of A. precatorius exhibits anti-inflammatory activity and may explain the usefulness of the leaves of this plant in the treatment of inflammatory disease conditions by traditional healers.

Key words:  Inflammatory response, croton oil, acetyl salicylic acid, Abrus precatorius

Anahtar Kelimeler

Inflammatory response, croton oil, acetyl salicylic acid, Abrus precatorius

Kaynakça

• Vane I, Bottling R. Inflammation and the mechanism of action of anti-inflammatory drugs. FASEB J 1987; 1: 89-96.
• Serhan CN, Takano T, Maddox JF. Aspirin triggered lipoxin A4 and stable analogs of lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. Adv Exp Med Biol 1999; 447: 133-149
• Rao BN, Anderson MB, Mussea JH, Gilbert JH. Sialyl Lewis X mimic derived from a pharmacophore search are selective inhibitors with anti-inflammatory activity. J Biol Chem. 1994; 269: 19663 – 19666
• Famaey JP. Phospholipases, Eicosanoid production and inflammation (Review). Clin Rheumatol 1982; 1: 84-91.
• Nath D, Sethi N. Commonly used abortifacient plants with special reference to their teratologic effects. Ethnopharmacol 1992; 36: 147-154.
• Rain-Tree (2004): http//www.raintree.com/abrus.htm.
• Chopra, R.N., (1958): Indigenous drugs of India. UN Dhar & Sons Pvt Ltd., Calcutta.
• Chopra, R.N., Nayar, S.L. & Chopra, I.C., (1956) : Glossary of Medicinal Plants, CSIR, New Delhi
• Toneli G, Thuboult L, Rinler I. A bioassay for the concomitant assessment of antiphilogistic and thymolytic activities of topically applied corticosteroids. Endocrinol 1965; 77: 625-634
• “Guidance document on acute oral toxicity testing “series on testing and assessment No. 24, Origination for economic operation and development OECD Environment, health and safety publication, Paris 2001
• Monceda S, Viane, JR. Mode of action of Aspirin like drugs. Adv Intern Med 1970; 24: 1-22.
• Branbaifa N, Georgewill OA. A quantitative assessment of topical antiphilogistic potencies of corticosteroids and non steroids. Medipharm Med Journal 1987; 1: 10-13.