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Delayed status epilepticus due to bupropion and lamotrigine overdose

Yıl 2013, Cilt: 18 Sayı: 3, 142 - 144, 02.10.2013

Öz

Bupropion is a well known atypical antidepressant marketed in the United States under the trade name Wellbutrin. In its sustained release form, it is also used for smoking cessation. It lowers seizure threshold and its potential to cause seizures has been widely publicized. Lamotrigine is a broad spectrum anticonvulsant with an extremely favorable side-effect profile and has thus rapidly become the preferred drug for a broad range of seizure types such as absence seizures, primary generalized epilepsy syndromes such as idiopathic generalized tonic-clonic seizures, juvenile myoclonic epilepsy as well as partial (focal) epilepsy. It is also used by psychiatrists as a mood stabilizer. We report a patient who presented with delayed status epilepticus following a failed suicidal attempt after overdosing on bupropion XL and lamotrigine.

Kaynakça

  • French LK, McKeown NJ, Hendrickson RG. Complete heart block and death following lamotrigine overdose. Clin Toxicol (Phila) 2011; 49: 330-333.
  • Herold TJ. Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder. CJEM 2006; 8: 361-364.
  • Barczyński B, Buszewicz G, Łuszczki JJ, et al. Low dose of bupropion significantly enhances the anticonvulsant activity of felbamate, lamotrigine and topiramate in mice. Eur J Pharmacol 2011; 650: 5505
  • Odishaw J, Chen C. Effects of steady-state bupropion on the pharmacokinetics of lamotrigine in healthy subjects. Pharmacotherapy 2000; 20: 1448-1453. Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008; 51: 412-4
Yıl 2013, Cilt: 18 Sayı: 3, 142 - 144, 02.10.2013

Öz

Kaynakça

  • French LK, McKeown NJ, Hendrickson RG. Complete heart block and death following lamotrigine overdose. Clin Toxicol (Phila) 2011; 49: 330-333.
  • Herold TJ. Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder. CJEM 2006; 8: 361-364.
  • Barczyński B, Buszewicz G, Łuszczki JJ, et al. Low dose of bupropion significantly enhances the anticonvulsant activity of felbamate, lamotrigine and topiramate in mice. Eur J Pharmacol 2011; 650: 5505
  • Odishaw J, Chen C. Effects of steady-state bupropion on the pharmacokinetics of lamotrigine in healthy subjects. Pharmacotherapy 2000; 20: 1448-1453. Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008; 51: 412-4
Toplam 4 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Case Report
Yazarlar

Nitin K. Sethi

Philippe Douyon Bu kişi benim

Ulrike Kaunzner Bu kişi benim

Prahlad K. Sethi Bu kişi benim

Josh Torgovnick Bu kişi benim

Frances Cukierwar Bu kişi benim

Justin Marcus Bu kişi benim

Yayımlanma Tarihi 2 Ekim 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 18 Sayı: 3

Kaynak Göster

APA Sethi, N. K., Douyon, P., Kaunzner, U., Sethi, P. K., vd. (2013). Delayed status epilepticus due to bupropion and lamotrigine overdose. EASTERN JOURNAL OF MEDICINE, 18(3), 142-144.
AMA Sethi NK, Douyon P, Kaunzner U, Sethi PK, Torgovnick J, Cukierwar F, Marcus J. Delayed status epilepticus due to bupropion and lamotrigine overdose. EASTERN JOURNAL OF MEDICINE. Ekim 2013;18(3):142-144.
Chicago Sethi, Nitin K., Philippe Douyon, Ulrike Kaunzner, Prahlad K. Sethi, Josh Torgovnick, Frances Cukierwar, ve Justin Marcus. “Delayed Status Epilepticus Due to Bupropion and Lamotrigine Overdose”. EASTERN JOURNAL OF MEDICINE 18, sy. 3 (Ekim 2013): 142-44.
EndNote Sethi NK, Douyon P, Kaunzner U, Sethi PK, Torgovnick J, Cukierwar F, Marcus J (01 Ekim 2013) Delayed status epilepticus due to bupropion and lamotrigine overdose. EASTERN JOURNAL OF MEDICINE 18 3 142–144.
IEEE N. K. Sethi, “Delayed status epilepticus due to bupropion and lamotrigine overdose”, EASTERN JOURNAL OF MEDICINE, c. 18, sy. 3, ss. 142–144, 2013.
ISNAD Sethi, Nitin K. vd. “Delayed Status Epilepticus Due to Bupropion and Lamotrigine Overdose”. EASTERN JOURNAL OF MEDICINE 18/3 (Ekim 2013), 142-144.
JAMA Sethi NK, Douyon P, Kaunzner U, Sethi PK, Torgovnick J, Cukierwar F, Marcus J. Delayed status epilepticus due to bupropion and lamotrigine overdose. EASTERN JOURNAL OF MEDICINE. 2013;18:142–144.
MLA Sethi, Nitin K. vd. “Delayed Status Epilepticus Due to Bupropion and Lamotrigine Overdose”. EASTERN JOURNAL OF MEDICINE, c. 18, sy. 3, 2013, ss. 142-4.
Vancouver Sethi NK, Douyon P, Kaunzner U, Sethi PK, Torgovnick J, Cukierwar F, Marcus J. Delayed status epilepticus due to bupropion and lamotrigine overdose. EASTERN JOURNAL OF MEDICINE. 2013;18(3):142-4.