Mean platelet volume as an indicator of disease in patients with acute pulmonary embolisms

Yıl 2014, Cilt: 19 Sayı: 2, 107 - 111, 05.12.2014

Aysel Sunnetcioglu , Sevdegul Karadas

Öz

Objective: Meanplatelet volume (MPV) is a simple and easy method of assessing plateletfunction in routine clinical practice. MPV is an important predictor of manydiseases; large platelets are more active than small platelets, and they are associated with shortened bleedingtimes. The data concerning MPV in pulmonary embolism are controversial.Therefore, the aim of this study was to evaluate MPV levels and platelet numbers inpatients with acute pulmonary embolisms.Materials and Methods: This retrospectivestudy was conducted in the emergency department of the Medical Faculty Hospital of Yuzuncu Yil University between January 2010 and April 2012. The study enrolled 67 patientswith acute PE (36 females and 31 males) and 53 healthy controls (31 femalesand 22 males). Theplatelet number and MPV values in patients with acute pulmonary embolism were reviewed. Results: There were no statisticallysignificant differences between the acute PE patients and the controls withrespect to the MPV values and platelet numbers (both, p>0.05). The MPV values wereinversely correlated with the platelet number in the patients with acute PE (r:0.388; p<0.001). Conclusion: These resultssuggest that MPV is not a reliable indicator for diagnosing acute pulmonaryembolism. Further studies are necessaryto confirm these findings.

Anahtar Kelimeler

Pulmonary embolism, platelet, mean platelet volume

Kaynakça

• Heit JA, Melton 3rd LJ, Lohse CM, et al. Incidence of venous thromboembolism in hospitalized patients vs community residents. Mayo Clin Proc 2001; 76: 1102–1110.
• Hirsh J, Hoak J. Management of deep vein thrombosis and pulmonary embolism. A statement for healthcare professionals. Council on Thrombosis (in consultation with the Council on Cardiovascular Radiology), American Heart Association. Circulation 1996; 93: 2212–2245.
• Dickson BC. Virchow's triad. Br J Haematol 2009; 145: 433.
• O’Malley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke 1995; 26: 9959
• Martin JF, Trowbridge EA, Salmon GL, Slater DN. The relationship between platelet and megakaryocyte volumes. Thromb Res 1982; 28: 447-459.
• Jackson SR, Carter JM. Platelet volume: laboratory measurement and clinical application. Blood Rev 1993; 7: 104-113.
• Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-460.
• Yuksel O, Helvaci K, Basar O, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets 2009; 20: 277-281.
• Mimidis K, Papadopoulos V, Kotsianidis J, et al. Alterations of platelet function, number and indexes during acute pancreatitis. Pancreatology 2004; 4: 22
• Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis 2010; 19: 66-72.
• Turhan O, Coban E, Inan D, Yalcin AN. Increased mean platelet volume in chronic hepatitis B patients with inactive disease. Med Sci Monit 2010; 16: 20220
• Purnak T, Efe C, Yuksel O, Beyazit Y, Ozaslan E, Altiparmak E. Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease. Ups J Med Sci 2011; 116: 208-211.
• Beyazit Y, Sayilir A, Torun S, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol 2012; 36: 162-168.
• Gasparyan AY, Sandoo A, Stavropoulos-Kalinoglou A, Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-alpha therapy. Rheumatol Int 2010; 30: 1125-1129.
• Varol E, Icli A, Uysal BA, Ozaydin M. Platelets indicates in patients with acute pulmonary embolism. Scand J Clin Lab Invest 2011; 71: 163-167.
• Kostrubiec M, Łabyk A, Pedowska-Włoszek J, et al. Mean platelet volume predicts early death in acute pulmonary embolism. Heart 2010; 96: 460-465.
• Hilal E, Neslihan Y, Gazi G, Sinan T, Zeynep Ayfer A. Does the mean platelet volume have any importance in patients with acute pulmonary embolism? Wien Klin Wochenschr 2013; 125: 3813
• Huczek Z, Kochman J, Filipiak KJ, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005; 46: 284-290.
• Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148-156.
• Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561-1571.
• Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-161.
• Bath P, Algert C, Chapman N, Neal B. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke 2004; 35: 622-626.
• Endler G, Klimesch A, Sunder-Plassmann H, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002; 117: 399-404.
• Huczek Z, Kochman J, Filipiak KJ, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005; 46: 284-290.
• Greisenegger S, Endler G, Hsieh K, et al. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 2004; 35: 1688-1691.
• Boos CJ, Lip GY. Assessment of mean platelet volume in coronary artery disease-what does it mean? Thromb Res 2007; 120: 11-13.
• Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009; 63: 1509-1515.
• Kisacik B, Tufan A, Kalyoncu U, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008; 75: 291-294.
• Basar Ö, Ertugrul I, Ibis M, et al. The relation between mean platelet volume and inflammatory bowel disease activity. Yeni Tıp Dergisi 2007; 24: 43
• Akcan AB, Oygucu SE, Özel D, Oygür N. Mean platelet volumes in babies of preeclamptic mothers. Blood Coagul Fibrinolysis 2011; 22: 285-287.
• Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation 2008; 117: 93-102.
• Prandoni P, Bilora F, Marchiori A, et al. An association between atherosclerosis and venous thrombosis. N Engl J Med 2003; 348: 1435-1441.
• Becattini C, Agnelli G, Prandoni P, et al. A prospective study on cardiovascular events after acute pulmonary embolism. Eur Heart J 2005; 26: 77-83.
• Trowbridge EA, Martin JF. The platelet volume dıstribution: a signature of the prethrombotic state in coronary heart disease. Thromb Haemost 1987; 58: 714-7
• Chatterji AK, Lynch EC, Garg SK, Amorosi EL, Karpatkin S. Circulating large platelets. N Engl J Med 1971; 284: 1440-1441.
• Van der Loo B, Martin JF. Megakaryocytes and platelets in vascular disease. Baillieres Clin Haematol 1997; 10: 109-123.
• Jackson SR, Carter JM. Platelet volume: laboratory measurement and clinical application. Blood Reviews 1993; 7: 104-113.
• Bessman JD, Williams LC, Gilmer PR. Mean platelet volume: The inverse relation between platelet size and count, and an artifact of other particles. Am J Clin Path 1981; 76: 189-193.
• Braekkan SK, Mathiesen EB, Njolstad I, et al. Mean platelet volume is a risk factor for venous thromboembolism: the Tromso Study, Tromso, Norway. J Thromb Haemost 2010; 8: 157-162.
• Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets 2012; 7: 1-4.
• Biino G, Portas L, Murgia F, et al. A population-based study of an Italian genetic isolate reveals that mean platelet volume is not a risk factor for thrombosis. Thromb Res 2012; 129: 8-13.
• Açıkgoz N, Karincaoglu Y, Ermis N, et al. Increased mean platelet volume in Behçet’s disease with thrombotic tendency. Tohoku J Exp Med 2010; 221: 119-1