The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

Abstract

In the present review, we aimed to evaluate the role of vitamin D in otolaryngological diseases. Since the recognition of vitamin D as a steroid hormone, it has attracted clinicians as a research issue due to its unique and complicated functions in human body processes. Numerous studies have investigated the association between vitamin D and human diseases, including in the otolaryngological field. However, although vitamin D alterations may theoretically be involved in the pathogenesis of several otolaryngological diseases, a clear association has not been demonstrated due to inconsistent results from the studies to date. Further randomized controlled trials with large patient populations are required to determine the exact role of vitamin D in otolaryngological diseases.

Keywords

• Vitamin D,otorhinolaryngologic diseases,immunity

Kaynakça

1. 1. Abuzeid WM, Akbar NA, Zacharek MA. Vitamin D and chronic rhinitis. Curr Opin Allergy Clin Immunol 2012;12:13-7.
2. 2. Akbar NA, Zacharek MA. Vitamin D: immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2011;19:224-8.
3. 3. Norman A. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008;88:491-9.
4. 4. Deluca HF. The metabolism, physiology, and function of vitamin D. In: Kumar R, editor. Vitamin D: Basic and Clinical Aspects. Boston: Martinus Nijhoff Publishers; 1984. p. 1-68.
5. 5. Kumar R. The metabolism and mechanism of action of 1,25-dihydroxyvitamin D3. Kidney Int 1986;30:793-803.
6. 6. Tsoukas CD, Provvedini DM, Manolagas SC. 1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone. Science 1984;224:1438-40.
7. 7. Mulligan JK, Bleier BS, O’Connell B, et al. Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol 2011;164:312-20.
8. 8. Wolff AE, Jones AN, Hansen KE. Vitamin D and musculoskeletal health. Nat Clin Pract Rheumatol 2008;4:580-8.

9. 9. Rigby WF, Stacy T, Fanger MW. Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest 1984;74:1451-5.
10. 10. Cantorna MT, Waddell A. The vitamin D receptor turns off chronically activated T cells. Ann N Y Acad Sci 2014;1317:70-5.
11. 11. Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007;179:1634-47.
12. 12. Heine G, Anton K, Henz BM, Worm M. 1alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro. Eur J Immunol 2002;32:3395-404.
13. 13. Tian HQ, Cheng L. The role of vitamin D in allergic rhinitis. Asia Pac Allergy 2017;7:65-73.
14. 14. Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl) 2010;88:441-50.
15. 15. Akcan FA, Dündar Y, Akcan HB, et al. Clinical role of vitamin D in prognosis of otitis media with effusion. Int J Pediatr Otorhinolaryngol 2018;105:1-5.
16. 16. Szodoray P, Nakken B, Gaal J, et al. The complex role of vitamin D in autoimmune diseases. Scand J Immunol 2008;68:261-9.
17. 17. Bartley J, Reid D, Morton RP. Prevalence of vitamin D deficiency among patients attending a general otolaryngology clinic in South Auckland. Ann Otol Rhinol Laryngol 2009;118:326-8.
18. 18. Taneja MK, Taneja V. Vitamin D deficiency in E.N.T. patients. Indian J Otolaryngol Head Neck Surg 2013;65:57-60.
19. 19. Osguthorpe JD. Pathophysiology of and potential new therapies for allergic rhinitis. Int Forum Allergy Rhinol 2013;3:384-92.
20. 20. Mai XM, Chen Y, Camargo CA Jr, Langhammer A. Serum 25-hydroxyvitamin D levels and self-reported allergic rhinitis in Norwegian adultsThe HUNT Study. Allergy 2014;69:488-93.
21. 21. Wjst M, Hyppönen E. Vitamin D serum levels and allergic rhinitis. Allergy 2007;62:1085-6.
22. 22. Aryan Z, Rezaei N, Camargo CA Jr. Vitamin D status, aeroallergen sensitization, and allergic rhinitis: A systematic review and meta-analysis. Int Rev Immunol 2017;36:41-53.
23. 23. Esposito S, Lelii M. Vitamin D and respiratory tract infections in childhood. BMC Infect Dis 2015;15:487.
24. 24. Esposito S, Baggi E, Bianchini S, Marchisio P, Principi N. Role of vitamin D in children with respiratory tract infections. Int J Immunopathol Pharmacol 2013;26:1-13.
25. 25. Marchisio P, Nazzari E, Torretta S, Esposito S, Principi N. Medical prevention of recurrent acute otitis media: an updated overview. Expert Rev Anti Infect Ther 2014;12:611-20.
26. 26. Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. J Steroid Biochem Mol Biol 2013;136:321-9.
27. 27. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 2008;5:136-43.
28. 28. Upala S, Sanguankeo A. Association between 25-Hydroxyvitamin D and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. J Clin Sleep Med 2015;11:1347.
29. 29. Neighbors CLP, Noller MW, Song SA, et al. Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med 2018;43:100-8.
30. 30. Persson LJ, Aanerud M, Hiemstra PS, et al. Chronic obstructive pulmonary disease is associated with low levels of vitamin D. PLos One 2012;7:e38934.
31. 31. Grace C, Vincent R, Aylwin SJ. High prevalence of vitamin D insufficiency in a United Kingdom urban morbidly obese population: implications for testing and treatment. Surg Obes Relat Dis 2014;10:355-60.
32. 32. Talaat HS, Kabel AM, Khaliel LH, Abuhadied G, El-Naga HA, Talaat AS. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx 2016;43:237-41.
33. 33. Vibert D, Kompis M, Hausler R. Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia. Ann Otol Rhinol Laryngol 2003;112;885-9.
34. 34. Rhim GI. Serum vitamin D and recurrent benign paroxysmal positional vertigo. Laryngoscope Investig Otolaryngol 2016;1:150-3.
35. 35. Maslovara S, Butkovic Soldo S, Sestak A, Milinkovic K, Rogic-Namacinski J, Soldo A. 25 (OH) D3 levels, incidence and recurrence of different clinical forms of benign paroxysmal positional vertigo. Braz J Otorhinolaryngol 2018;84:453-9.