Evaluation of the correlation of 25-hydroxyvitamin-D serum levels with allergic rhinitis

Yıl 2015, , 19 - 22, 19.09.2015

Esin Yalçınkaya Mehmet Emin Tunçkaşık İsmail Güler Sinan Kocatürk Özge Gündüz

https://doi.org/10.2399/jmu.2015001005

Öz

Objective: Recent studies point to a relationship between allergic diseases and vitamin D deficiency. This relationship seems to be associated with immune-modulator effects of the derivatives of vitamin D. However, there are limited number of studies on the relationship between allergic rhinitis and derivatives of vitamin D. We planned our study to investigate this issue. Methods: The study group was composed of 30 patients diagnosed with allergic rhinitis according to ARIA (Allergic Rhinitis and its Impact on Asthma) Criteria. The control group included 30 patients of the same age and gender without any allergic rhinitis disease. The patients with an underlying disease which may cause deficiency of calcium and vitamin D were excluded. The significance of the difference between study and control groups in terms of serum 25-hydroxy (OH) vitamin D levels was also evaluated. Results: It was determined that the levels of vitamin D were within normal (10-90 ng/mL) limits in both groups. It was found out that the mean serum 25(OH)vitamin D level (15.39 ng/mL) of the study group was significantly lower than the control group (53.80 ng/mL) (p=0.00). No significant difference was found between the genders in terms of vitamin D levels (p=0.398). Conclusion: It is necessary to do more researches on the effects of vitamin D derivatives on allergic rhinitis. This study indicates that a vitamin D deficiency should be taken into consideration during the treatment for resistant allergic rhinitis patients.

Anahtar Kelimeler

Allergic rhinitis, 25-hydroxyvitamin D, allergic diseases

Alerjik rinit ile 25-hidroksivitamin D serum seviyelerinin ilişkisinin değerlendirilmesi

Öz

Amaç: Son yıllarda alerjik hastalıklarla, D vitamini eksikliği arasındaki ilişkiye dikkat çeken çalışmalar bulunmaktadır. Bu ilişki D vitamini türevlerinin immünmodülatör etkilerine bağlanmıştır. Ancak alerjik rinit ile D vitamini türevlerinin ilişkisine dair sınırlı sayıda çalışma bulunmaktadır. Bu konuya ışık tutabilmek amacıyla çalışmamızı planladık. Yöntem: Çalışma grubu ARIA (Allergic Rhinitis and its Impact on Asthma) kriterlerine göre alerjik rinit tanısı konulan 30 hastadan oluşturulmuştur. Kontrol grubuna ise aynı yaş ve cinsiyetlerde alerjik rinit hastalığı bulunmayan 30 hasta dahil edilmiştir. Altta yatan kalsiyum ve D vitamini eksikliği yapabilecek hastalığı bulunan hastalar çalışma dışında bırakılmıştır. Serum 25-hidroksi (OH) vitamin D düzeyleri açısından çalışma ve kontrol grupları arasında anlamlı fark olup olmadığı değerlendirilmiştir. Bulgular: Her iki grupta D vitamini seviyelerinin normal (10-90 ng/mL) sınırlarda olduğu saptanmıştır. Çalışma grubunun ortalama serum 25(OH)vitamin D düzeyinin (15.39 ng/mL) kontrol grubuna (53.80 ng/mL) göre anlamlı olarak (p=0.00) düşük olduğu saptanmıştır. D vitamini düzeyleri açısından cinsiyetler arasında anlamlı farklılık saptanmamıştır (p=0.398). Sonuç: D vitamini türevlerinin alerjik rinit üzerindeki etkilerine dair daha fazla çalışma yapılması gerekmektedir. Bu çalışma özellikle tedaviye dirençli alerjik rinit hastalarında D vitamini eksikliğinin de göz önünde bulundurulması gerektiğine dikkat çekmektedir.

Anahtar Kelimeler

Alerjik rinit, 25-hidroksivitamin D, alerjik hastalıklar

Kaynakça

• Schauber J, Gallo RL. Vitamin D deficiency and asthma: not a strong link-yet. J Allergy Clin Immunol 2008;121:782–3.
• Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007;120:1031–5.
• Clifford RL, Knox AJ. Vitamin D – a new treatment for airway remodelling in asthma? Br J Pharmacol 2009;158:1426–8.
• Sidbury R, Sullivan AF, Thadhani RI, Camargo CA Jr. Randomizedcontrolled trial of vitamin D supplementation for winter-related atopicdermatitis in Boston: a pilot study. Br J Dermatol 2008;159:245–7.
• Bousquet J, Khaltaev N, Cruz AA, et al.; World Health Organization; GA(2)LEN; AllerGen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63 Suppl 86:8–160.
• Moradzadeh B. Larijani AA, Keshtkar A, et al. Normative values of vitamin D among Iranian population: a population based study. Int J Osteoporosis Metab Disorders 2008;1:8–15.
• Neyestani TR, Gharavi A, Kalayi A. Iranian diabetics may not be vitamin D deficient more than healthy subjects. Acta Med Iran 2008;46:337–41.
• Kavut AB, Kapaklıoglu F. Diagnostic tools for allergic rhinitis and asthma. J Med Updates 2012:8:22–30.
• Pichler J, Gerstmayr M, Szépfalusi Z, Urbanek R, Peterlik M, Willheim M. 1 alpha,25(OH)2D3 inhibits not only Th1 but also Th2 differentiation in human cord blood T cells. Pediatr Res 2002;52:12–8.
• Wjst M, Hyppönen E. Vitamin D serum levels and allergic rhini- tis. Allergy 2007;62:1085–6.
• Hyppönen E, Berry DJ, Wjst M, Power C. Serum 25-hydroxyvit- amin D and Ig E – a significant but nonlinear relationship. Allergy 2009;64:613–20.
• Hollis BW. Assessment of vitamin D status and definition of a nor- mal circulating range of 25-hydroxyvitamin D. Curr Opin Endocrinol Diabetes Obes 2008;15:489–94.
• Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010;125:995–1000.
• Hyppönen E, Sovio U, Wjst M, et al. Infant vitamin D supplemen- tation and allergic conditions in adulthood: Northern Finland birth cohort 1966. N Y Acad Sci 2004;1037:84–95.
• Bonanno A, Gangemi S, La Grutta S, et al. 25-Hydroxyvitamin D, IL-31, and IL-33 in children with allergic disease of the airways. Mediators Inflamm 2014;2014:520241.
• Volume5 |Issue1 |April2015 21
• San T, Muluk NB, Cingi C. 1,25(OH)2D3 and specific Ig E levels in children with recurrent tonsillitis, and allergic rhinitis. Int J Pediatr Otorhinolaryngol 2013;77:1506–11.
• Wjst M, Dold S. Genes, factor X and allergens: what causes aller- gic disease. Allergy 1999;54:757–9.
• Wjst M. The vitamin D slant on allergy. Pediatr Allergy Immunol 2006;17:477–83.
• Arshi S, halehbaghi B, Kamrava SK, Aminlou M. Vitamin D serum levels in allergic rhinitis: any difference from normal population? Asia Pac Allergy 2012;2:45–8.
• This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
• NC-ND0) Licence (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted noncommercial use, distribution, and reproduc
• tion in any medium, provided the original work is properly cited.
• Please cite this article as: Yalçınkaya E, Tunçkaflık ME, Güler ‹, Kocatürk S, Gündüz Ö. Evaluation of the correlation of 25-hydroxyvitamin-D serum
• levels with allergic rhinitis. ENT Updates 2015;5(1):19–22.