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Vestibüler flikayeti olmayan migren hastalarında kontralateral otoakustik emisyon süpresyonu

Yıl 2015, Cilt: 5 Sayı: 3, 119 - 123, 14.01.2016

Öz

Amaç: Bu çalışmanın amacı duyusal modülasyon bozukluğuna yol açan migren hastalığı olan kişilerde işitme sistemi reşeksi ölçümünde kullanılan bir test olan kontralateral otoakustik süpresyon testinin sonuçlarının değerlendirilmesidir.

Yöntem: Çalışmaya nöroloji polikliniğine başvuran, Uluslararası Başağrısı Derneği’nin 2004 yılı kriterlerine göre migren tanısı alan ve vestibüler şikayeti olmayan gönüllü migren hastaları ve sağlıklı gönüllüler dahil edildi. Bütün gönüllülere tam otolojik muayene, saf ses odyometri testi yapıldı. Bilateral otoakustik emisyon yanıtı alınan 30 gönüllü migren hastası ve karşılaştırma için yaş ve cinsiyet özellikleri gönüllü hasta grubuna benzeyen 30 sağlıklı gönüllü çalışmaya dahil edildi. Çalışmaya dahil edilen gönüllülere kontralateral 50 dB SPL geniş bant gürültü ile maske yapılarak 65 dB click uyaran ile maskeli ve maskesiz otoakustik emisyon ölçümleri yapıldı. Her iki gruptan elde edilen veriler karşılaştırıldı.

Bulgular: Sağlıklı gönüllülerin değerlendirilen 60 kulağının 40’ında (%67) süpresyon testi pozitif olarak tespit edilirken migren hastalarının değerlendirilen 60 kulağından 30’unda (%50) süpresyon testi pozitif olarak tespit edildi. Fakat süpresyon pozitişiği oranlarında ve süpresyon emisyon değerlerinde istatistiksel olarak anlamlı bir fark izlenmedi. İki grup arasında istatistiksel olarak anlamlı bir fark olmasa da migrenli grupta kontralateral supresyon cevaplarında azalma izlendi.

Sonuç: Vestibüler şikayeti olmayan migren hastalarında normal kişilerle karşılaştırıldığında istatistiksel olarak anlamlı olmasa da kontralateral süpresyon cevaplarında bir azalma izlenmektedir. Daha büyük seri içeren yeni çalışmalar ile kontralateral otoakustik emisyon testi vestibüler şikayeti olmayan migren hastalarında odyovestibüler şikayetlerin erken tanısında kullanabileceği kanaatindeyiz.

Anahtar sözcükler: Kontralateral süpresyon testi, MOC reşeksi, non-vestibüler migren, otoakustik emisyon.

Kaynakça

  • Lee H, Lopez I, Ishiyama A, Baloh RW. Can migraine damage the inner ear? Arch Neurol 2000;57:1631–4.
  • Hamed SA, Youssef AH, Elattar AM. Assessment of cochlear and auditory pathways in patients with migraine. Am J Otolaryngol 2012;33:385–94.
  • Chu CH, Liu CJ, Fuh JL, et al. Migraine is a risk factor for sud- den sensorineural hearing loss: a nationwide population-based study. Cephalalgia 2013;33:80–6.
  • Evans RW, Ishiyama G. Migraine with transient unilateral hear- ing loss and tinnitus. Headache 2009;49:756–8.
  • Lilaonitkul W, Guinan JJ Jr. Human medial olivocochlear reflex: effects as functions of contralateral, ipsilateral, and bilateral elic- itor bandwidths. J Assoc Res Otolaryngol 2009;10:459– 70.
  • Thiers FA, Burgess BJ, Nadol JB Jr. Reciprocal innervation of outer hair cells in a human infant. J Assoc Res Otolaryngol 2002;3:269–78.
  • Sridhar TS, Liberman MC, Brown MC, et al. A novel choliner- gic “slow effect” of efferent stimulation on cochlear potentials in the guinea pig. J Neurosci 1995;15:3667–78.
  • Guinan JJ Jr, Cooper NP. Medial olivocochlear efferent inhibi- tion of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation. J Acoust Soc Am 2008; 124:1080–92.
  • Bolay H, Bayazit YA, Gündüz B, et al. Subclinical dysfunction of cochlea and cochlear efferents in migraine: an otoacoustic emis- sion study. Cephalalgia 2008;28:309–17.
  • Guinan JJ Jr. Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans. Ear Hear 2006;27:589–607.
  • Tekeli H, Şenol MG, Özdağ F, et al. Evaluation of olfactory function in migraineurs during the migraine-free period with odor identification test. J Med Updates 2014;4:1–5
  • Kayan A, Hood JD. Neuro-otological manifestations of migraine. Brain 1984;107:1123–42.
  • Dash AK, Panda N, Khandelwal G, et al. Migraine and audiovestibular dysfunction: is there a correlation? Am J Otolaryngol 2008;29:295–9.
  • Cal R, Bahmad Jr F . Migraine associated with auditory-vestibu- lar dysfunction. Braz J Otorhinolaryngol 2008;74:606–12.
  • Ambrosini A, Rossi P, De Pasqua V, et al. Lack of habituation causes high intensity dependence of auditory evoked cortical potentials in migraine. Brain 2003;126:2009–15.
  • van der Feltz-Cornelis CM, Biemans H, Timmer J. Hearing voices: does it give your patient a headache? A case of auditory hallucinations as acoustic aura in migraine. Neuropsychiatr Dis Treat 2012;8:105–11
  • Khalfa S, Bougeard R, Morand N, et al. Peripheral auditory asymmetry in infantile autism. Eur J Neurosci 2001;13:628–32.
  • Murdin L, Premachandra P, Davies R. Sensory dysmodulation in vestibular migraine: an otoacoustic emission suppression study. Laryngoscope 2010;120:1632–6.
  • This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
  • NC-ND3.0) Licence (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted noncommercial use, distribution, and reproduc
  • tion in any medium, provided the original work is properly cited.
  • Please cite this article as: Özgür A, Tüfekçi A, Yiğider AP, Terzi S, Kırbaş S, Özergin Coşkun Z, Dursun E. Contralateral suppression of otoacoustic
  • emissions in migraine patients without vestibular involvement. ENT Updates 2015;5(3):119–123.

Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement

Yıl 2015, Cilt: 5 Sayı: 3, 119 - 123, 14.01.2016

Öz

Objective: Our aim was to investigate contralateral suppression of
otoacoustic emission for the evaluation of auditory reflex in patients
with migraine which is a disease that may cause dysfunction of sensorial modulation.
Methods: Voluntary migraine patients without vestibular symptoms
who consulted to Neurology Clinic, and diagnosed according to the
IHS 2004 criteria, and healthy volunteers were included in the study.
All volunteers underwent complete otorhinolaryngologic and puretone audiometric examinations. Thirty voluntary migraine patients with
bilateral otoacoustic emission measurements, and 30 healthy volunteers
matched in terms of age and sex were included in the study. Otoacoustic
emission measurements were obtained with 65 dB SPL click stimulus
with and without mask by masking with contralateral 50 dB SPL broad
band noise. Responses were compared between two groups.
Results: Positive result was obtained in suppression tests in 40 of 60
(67%) ears of healthy volunteers and in 30 of 60 (50%) ears of
migraine patients. However, there was no statistically significant difference between groups regarding positive suppression frequency and
suppression values. Even though a statistically significant difference
between migraine patients without vestibular involvement and control group was not seen, there was a decrease in contralateral suppression responses in the migraine group.
Conclusion: Although it is statistically insignificant, we have demonstrated that migraine patients without vestibular symptoms showed a decrease
in the suppression values compared to the healthy volunteers. We believe
that in new studies with larger series, contralateral otoacoustic emission
suppression test can be used as an early tool to diagnose audiovestibular
symptoms in migraine patients without any vestibular involvement. 

Kaynakça

  • Lee H, Lopez I, Ishiyama A, Baloh RW. Can migraine damage the inner ear? Arch Neurol 2000;57:1631–4.
  • Hamed SA, Youssef AH, Elattar AM. Assessment of cochlear and auditory pathways in patients with migraine. Am J Otolaryngol 2012;33:385–94.
  • Chu CH, Liu CJ, Fuh JL, et al. Migraine is a risk factor for sud- den sensorineural hearing loss: a nationwide population-based study. Cephalalgia 2013;33:80–6.
  • Evans RW, Ishiyama G. Migraine with transient unilateral hear- ing loss and tinnitus. Headache 2009;49:756–8.
  • Lilaonitkul W, Guinan JJ Jr. Human medial olivocochlear reflex: effects as functions of contralateral, ipsilateral, and bilateral elic- itor bandwidths. J Assoc Res Otolaryngol 2009;10:459– 70.
  • Thiers FA, Burgess BJ, Nadol JB Jr. Reciprocal innervation of outer hair cells in a human infant. J Assoc Res Otolaryngol 2002;3:269–78.
  • Sridhar TS, Liberman MC, Brown MC, et al. A novel choliner- gic “slow effect” of efferent stimulation on cochlear potentials in the guinea pig. J Neurosci 1995;15:3667–78.
  • Guinan JJ Jr, Cooper NP. Medial olivocochlear efferent inhibi- tion of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation. J Acoust Soc Am 2008; 124:1080–92.
  • Bolay H, Bayazit YA, Gündüz B, et al. Subclinical dysfunction of cochlea and cochlear efferents in migraine: an otoacoustic emis- sion study. Cephalalgia 2008;28:309–17.
  • Guinan JJ Jr. Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans. Ear Hear 2006;27:589–607.
  • Tekeli H, Şenol MG, Özdağ F, et al. Evaluation of olfactory function in migraineurs during the migraine-free period with odor identification test. J Med Updates 2014;4:1–5
  • Kayan A, Hood JD. Neuro-otological manifestations of migraine. Brain 1984;107:1123–42.
  • Dash AK, Panda N, Khandelwal G, et al. Migraine and audiovestibular dysfunction: is there a correlation? Am J Otolaryngol 2008;29:295–9.
  • Cal R, Bahmad Jr F . Migraine associated with auditory-vestibu- lar dysfunction. Braz J Otorhinolaryngol 2008;74:606–12.
  • Ambrosini A, Rossi P, De Pasqua V, et al. Lack of habituation causes high intensity dependence of auditory evoked cortical potentials in migraine. Brain 2003;126:2009–15.
  • van der Feltz-Cornelis CM, Biemans H, Timmer J. Hearing voices: does it give your patient a headache? A case of auditory hallucinations as acoustic aura in migraine. Neuropsychiatr Dis Treat 2012;8:105–11
  • Khalfa S, Bougeard R, Morand N, et al. Peripheral auditory asymmetry in infantile autism. Eur J Neurosci 2001;13:628–32.
  • Murdin L, Premachandra P, Davies R. Sensory dysmodulation in vestibular migraine: an otoacoustic emission suppression study. Laryngoscope 2010;120:1632–6.
  • This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
  • NC-ND3.0) Licence (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted noncommercial use, distribution, and reproduc
  • tion in any medium, provided the original work is properly cited.
  • Please cite this article as: Özgür A, Tüfekçi A, Yiğider AP, Terzi S, Kırbaş S, Özergin Coşkun Z, Dursun E. Contralateral suppression of otoacoustic
  • emissions in migraine patients without vestibular involvement. ENT Updates 2015;5(3):119–123.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Abdulkadir Özgür

Ahmet Tüfekçi Bu kişi benim

Ayşe Pelin Yiğider Bu kişi benim

Suat Terzi Bu kişi benim

Serkan Kırbaş Bu kişi benim

Zerrin Özergin Çoşkun Bu kişi benim

Engin Dursun Bu kişi benim

Yayımlanma Tarihi 14 Ocak 2016
Gönderilme Tarihi 14 Ocak 2016
Yayımlandığı Sayı Yıl 2015 Cilt: 5 Sayı: 3

Kaynak Göster

APA Özgür, A., Tüfekçi, A., Yiğider, A. P., Terzi, S., vd. (2016). Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement. ENT Updates, 5(3), 119-123.
AMA Özgür A, Tüfekçi A, Yiğider AP, Terzi S, Kırbaş S, Özergin Çoşkun Z, Dursun E. Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement. ENT Updates. Ocak 2016;5(3):119-123.
Chicago Özgür, Abdulkadir, Ahmet Tüfekçi, Ayşe Pelin Yiğider, Suat Terzi, Serkan Kırbaş, Zerrin Özergin Çoşkun, ve Engin Dursun. “Contralateral Suppression of Otoacoustic Emissions in Migraine Patients Without Vestibular Involvement”. ENT Updates 5, sy. 3 (Ocak 2016): 119-23.
EndNote Özgür A, Tüfekçi A, Yiğider AP, Terzi S, Kırbaş S, Özergin Çoşkun Z, Dursun E (01 Ocak 2016) Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement. ENT Updates 5 3 119–123.
IEEE A. Özgür, A. Tüfekçi, A. P. Yiğider, S. Terzi, S. Kırbaş, Z. Özergin Çoşkun, ve E. Dursun, “Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement”, ENT Updates, c. 5, sy. 3, ss. 119–123, 2016.
ISNAD Özgür, Abdulkadir vd. “Contralateral Suppression of Otoacoustic Emissions in Migraine Patients Without Vestibular Involvement”. ENT Updates 5/3 (Ocak 2016), 119-123.
JAMA Özgür A, Tüfekçi A, Yiğider AP, Terzi S, Kırbaş S, Özergin Çoşkun Z, Dursun E. Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement. ENT Updates. 2016;5:119–123.
MLA Özgür, Abdulkadir vd. “Contralateral Suppression of Otoacoustic Emissions in Migraine Patients Without Vestibular Involvement”. ENT Updates, c. 5, sy. 3, 2016, ss. 119-23.
Vancouver Özgür A, Tüfekçi A, Yiğider AP, Terzi S, Kırbaş S, Özergin Çoşkun Z, Dursun E. Contralateral suppression of otoacoustic emissions in migraine patients without vestibular involvement. ENT Updates. 2016;5(3):119-23.