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Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma

Yıl 2016, Cilt: 6 Sayı: 3, 116 - 120, 31.12.2016

Öz

Objective: To investigate the healing effects of topical dexpanthenol on acute tympanic membrane (TM) perforations in rats through observations of healing time and histopathological changes.
Methods: A total of 20 Sprague-Dawley rats were included in the study. Every perforation was formed at the pars tensa of TMs with a size 2 mm in diameter. The right TM of each rat was treated with topical dexpanthenol for 2 days (treatment group); on the other hand, no topical agent was applied on the left TMs of rats (sham group). All TMs were examined under otomicroscopy at the third, fifth, and seventh days to determine the healing of TM perforations. Moreover, TMs were
histopathologically examined to assess neovascularization, collagenization, fibroblastic activity, inflammatory cell positivity at the lamina propria (LP) layer of TMs.
Results: The TM perforations in the treatment group healed significantly earlier (p<0.05). The collagenization at LP was significantly higher in the treatment group (p<0.05), while neovascularization and inflammatory cell positivity were significantly higher in the sham group (p<0.05). The fibroblastic activity was higher in the treatment group although no statistically significant difference was determined.
Conclusion: The findings of the current study suggest that dexpanthenol may accelerate the healing of acute TM perforation.

Kaynakça

  • 1. Cohen D, Tamir D. The prevalence of middle ear pathologies in Jerusalem school children. Am J Otol 1989;10:456–9.
  • 2. Hellstrom S, Laurent C. Hyaluronan and healing of tympanic membrane perforations. An experimental study. Acta Otolaryngol Suppl 1987;42:54–61.
  • 3. Ishibashi T, Shinogami M, Ishimoto SI, Yoshida K, Kaga K. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations. Acta Otolaryngol 1998;118:701–4.
  • 4. Laurent C, Hellstrom S, Fellenius E. Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties. Arch Otolaryngol Head Neck Surg 1998;114:1435–41.
  • 5. Spandow O, Hellstrom S. Healing of tympanic membrane perforation- a complex process influenced by a variety of factors. Acta Otolaryngol Suppl 1992;492:90–3.
  • 6. Amoils CP, Jackler RK, Lustig LR. Repair of chronic tympanic membrane perforations using epidermal growth factor. Otolaryngol Head Neck Surg 1992;107:669–83.
  • 7. Dere H, Ünal A, Özcan ‹, Yard›mc› S, Ergül G, Titiz A, Aksoy F. Travmatik timpan membran perforasyon iyileflmesinde basic fibroblast growth faktorün etkisinin histolojik incelenmesi. Türk Otolarengoloji Arflivi 1997;35:33–7.
  • 8. Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 2002;3:427–33.
  • 9. Johnson AP, Smallman LA, Kent SE. The mechanism of healing of tympanic membrane perforations. A two-dimensional histological study in guinea pigs. Acta Otolaryngol 1990;109:406–15.
  • 10. Stenfors LE, Carlsoo B, Salen B, Winblad B. Repair of experimental tympanic membrane perforations. Acta Otolaryngol 1980;90: 332–41.
  • 11. Fina M, Bresnick S, Baird A, Ryan A. Improved healing of tympanic membrane perforations with basic fibroblast growth factor. Growth Factors 1991;5:265–72.
  • 12. Mondain M, Saffiedine S, Uziel A. Fibroblast growth factor improves the healing of experimental tympanic membrane perforations. Acta Otolaryngol 1991;111:337–41.
  • 13. Vrabec JT, Schwaber MK, Davidson JM, Clymer MA. Evaluation of basic fibroblast growth factor in tympanic membrane repair. Laryngoscope 1994;104:1059–64.
  • 14. O’Daniel TG, Petitjean M, Jones SC, et al. Epidermal growth factor binding and action on tympanic membranes. Ann Otol Rhinol Laryngol 1990;99:80–4.
  • 15. Kaftan H, Herzog M, Miehe B, Hosemann W. Topical application of transforming growth factor-beta1 in acute traumatic tympanic membrane perforations: an experimental study in rats. Wound Rep Reg 2006;14:453–6.
  • 16. Kehrl W, Sonnemann U. Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior. [Article in German] Laryngorhinootologie 1998;77:506–12.
  • 17. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy (Cairo) 2014;2014:635490.
  • 18. Özel BF, Yasan H, Çirifl M, Do¤ru H, Çand›r Ö. Miringoskleroz geliflimi ve kulak zar› perforasyonu iyileflmesi üzerine farkl› ajanlar› n etkileri. KBB-Forum 2005;4:123–7.
  • 19. Gunes Bilgili S, Calka O, Akdeniz N, Bayram I, Metin A. The effects of retinoids on secondary wound healing: biometrical and histopathological study in rats. J Dermatolog Treat 2013;24:283– 9.
  • 20. Yardimci I, Karakan T, Resorlu B, et al. The effect of intraurethral dexpanthenol on healing and fibrosis in rats with experimentally induced urethral trauma. Urology 2015;85:274.e9–13.
Yıl 2016, Cilt: 6 Sayı: 3, 116 - 120, 31.12.2016

Öz

Kaynakça

  • 1. Cohen D, Tamir D. The prevalence of middle ear pathologies in Jerusalem school children. Am J Otol 1989;10:456–9.
  • 2. Hellstrom S, Laurent C. Hyaluronan and healing of tympanic membrane perforations. An experimental study. Acta Otolaryngol Suppl 1987;42:54–61.
  • 3. Ishibashi T, Shinogami M, Ishimoto SI, Yoshida K, Kaga K. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations. Acta Otolaryngol 1998;118:701–4.
  • 4. Laurent C, Hellstrom S, Fellenius E. Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties. Arch Otolaryngol Head Neck Surg 1998;114:1435–41.
  • 5. Spandow O, Hellstrom S. Healing of tympanic membrane perforation- a complex process influenced by a variety of factors. Acta Otolaryngol Suppl 1992;492:90–3.
  • 6. Amoils CP, Jackler RK, Lustig LR. Repair of chronic tympanic membrane perforations using epidermal growth factor. Otolaryngol Head Neck Surg 1992;107:669–83.
  • 7. Dere H, Ünal A, Özcan ‹, Yard›mc› S, Ergül G, Titiz A, Aksoy F. Travmatik timpan membran perforasyon iyileflmesinde basic fibroblast growth faktorün etkisinin histolojik incelenmesi. Türk Otolarengoloji Arflivi 1997;35:33–7.
  • 8. Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 2002;3:427–33.
  • 9. Johnson AP, Smallman LA, Kent SE. The mechanism of healing of tympanic membrane perforations. A two-dimensional histological study in guinea pigs. Acta Otolaryngol 1990;109:406–15.
  • 10. Stenfors LE, Carlsoo B, Salen B, Winblad B. Repair of experimental tympanic membrane perforations. Acta Otolaryngol 1980;90: 332–41.
  • 11. Fina M, Bresnick S, Baird A, Ryan A. Improved healing of tympanic membrane perforations with basic fibroblast growth factor. Growth Factors 1991;5:265–72.
  • 12. Mondain M, Saffiedine S, Uziel A. Fibroblast growth factor improves the healing of experimental tympanic membrane perforations. Acta Otolaryngol 1991;111:337–41.
  • 13. Vrabec JT, Schwaber MK, Davidson JM, Clymer MA. Evaluation of basic fibroblast growth factor in tympanic membrane repair. Laryngoscope 1994;104:1059–64.
  • 14. O’Daniel TG, Petitjean M, Jones SC, et al. Epidermal growth factor binding and action on tympanic membranes. Ann Otol Rhinol Laryngol 1990;99:80–4.
  • 15. Kaftan H, Herzog M, Miehe B, Hosemann W. Topical application of transforming growth factor-beta1 in acute traumatic tympanic membrane perforations: an experimental study in rats. Wound Rep Reg 2006;14:453–6.
  • 16. Kehrl W, Sonnemann U. Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior. [Article in German] Laryngorhinootologie 1998;77:506–12.
  • 17. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy (Cairo) 2014;2014:635490.
  • 18. Özel BF, Yasan H, Çirifl M, Do¤ru H, Çand›r Ö. Miringoskleroz geliflimi ve kulak zar› perforasyonu iyileflmesi üzerine farkl› ajanlar› n etkileri. KBB-Forum 2005;4:123–7.
  • 19. Gunes Bilgili S, Calka O, Akdeniz N, Bayram I, Metin A. The effects of retinoids on secondary wound healing: biometrical and histopathological study in rats. J Dermatolog Treat 2013;24:283– 9.
  • 20. Yardimci I, Karakan T, Resorlu B, et al. The effect of intraurethral dexpanthenol on healing and fibrosis in rats with experimentally induced urethral trauma. Urology 2015;85:274.e9–13.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Sinem Demirdelen Bu kişi benim

Mehmet İmamoğlu Bu kişi benim

Selçuk Arslan

İsmail Sayğın Bu kişi benim

Yayımlanma Tarihi 31 Aralık 2016
Gönderilme Tarihi 24 Temmuz 2017
Yayımlandığı Sayı Yıl 2016 Cilt: 6 Sayı: 3

Kaynak Göster

APA Demirdelen, S., İmamoğlu, M., Arslan, S., Sayğın, İ. (2016). Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma. ENT Updates, 6(3), 116-120.
AMA Demirdelen S, İmamoğlu M, Arslan S, Sayğın İ. Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma. ENT Updates. Aralık 2016;6(3):116-120.
Chicago Demirdelen, Sinem, Mehmet İmamoğlu, Selçuk Arslan, ve İsmail Sayğın. “Topikal Dekspantenol Uygulaması Akut Kulak Zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel Bir çalışma”. ENT Updates 6, sy. 3 (Aralık 2016): 116-20.
EndNote Demirdelen S, İmamoğlu M, Arslan S, Sayğın İ (01 Aralık 2016) Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma. ENT Updates 6 3 116–120.
IEEE S. Demirdelen, M. İmamoğlu, S. Arslan, ve İ. Sayğın, “Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma”, ENT Updates, c. 6, sy. 3, ss. 116–120, 2016.
ISNAD Demirdelen, Sinem vd. “Topikal Dekspantenol Uygulaması Akut Kulak Zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel Bir çalışma”. ENT Updates 6/3 (Aralık 2016), 116-120.
JAMA Demirdelen S, İmamoğlu M, Arslan S, Sayğın İ. Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma. ENT Updates. 2016;6:116–120.
MLA Demirdelen, Sinem vd. “Topikal Dekspantenol Uygulaması Akut Kulak Zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel Bir çalışma”. ENT Updates, c. 6, sy. 3, 2016, ss. 116-20.
Vancouver Demirdelen S, İmamoğlu M, Arslan S, Sayğın İ. Topikal dekspantenol uygulaması akut kulak zarı perforasyonlarının iyileşmesini hızlandırmaktadır: Deneysel bir çalışma. ENT Updates. 2016;6(3):116-20.