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The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Yıl 2017, Cilt: 7 Sayı: 2, 99 - 103, 30.09.2017

Öz

Objective: To reveal whether if neutrophil
to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) rates
are useful or not in children followed-up due to pathological cervical
lymphadenopathy (LAP) of unknown etiology who have a normal hematologic
examination.




Methods: A
total of 100 children admitted to the otorhinolaryngology clinic between
2014 and 2017 with the complaint of swelling in the neck without any
etiology revealed on examination and established with the diagnosis of
idiopathic pathological LAP were retrospectively included in the study.
The control group consisted of 100 children who did not have any
infectious condition and could be considered healthy in terms of
examination and laboratory findings. Patients' and the control group's
age, gender, clinical history, disease course and examination findings
were screened from the patients' records in the clinic.




Results:
Mean white blood cell and lymphocyte count parameters in the patient
group were higher than the control group, and the difference was
statistically significant (p=0.008 and p=0.001, respectively). In the
patient group, mean NLR and PLR values were significantly lower than the
control group (p=0.009 and p=0.020, respectively).




Conclusion: NLR
and PLR rates may be well correlated with inflammation in children
followed-up due to pathologic cervical LAP with unknown etiology.

Kaynakça

  • Perkins SL, Segal GH, Kjeldsberg CR. Work-up of lym- phadenopathy in children. Semin Diagn Pathol 1995;12:284–7. 2. Twist CJ, Link MP. Assessment of lymphadenopathy in chil- dren. Pediatr Clin North Am 2002;49:1009–25. 3. Locke R, MacGregor F, Kubba H. The validation of an algo- rithm for the management of paediatric cervical lymphadenopa- thy. Int J Pediatr Otorhinolaryngol 2016;81:5–9. 4. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil- lymphocyte count ratio predict bacteremia better than conven- tional infection markers in an emergency care unit. Crit Care 2010;14:R192–5. 5. Zahorec R. Ratio of neutrophil to lymphocyte counts – rapid and simple parameter of systemic inflammation and stress in critical- ly ill. Bratisl Lek Listy 2001;102:5–14. 6. Balta S, Demirkol S, Unlu M, Arslan Z, Celik T. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions. Br J Cancer 2013;109:3125–6. 7. Balta S, Ozturk C, Kurtoglu E. The neutrophil-lymphocyte ratio is not enough to describe inflammatory condition. Eur Arch Otorhinolaryngol 2014;271:1839–40. 8. Demir D, Akçam MT, Karakoç Ö, Öngörü Ö, Yetifler S. Bafl boyun kitlelerinde ince i¤ne aspirasyon biopsisinin tan›sal de¤eri. KBB-Forum 2006;5:5–11. 9. Yalç›n fi. Boyun kitleleri. In: Kulak burun bo¤az hastal›klar› ve bafl boyun cerrahisi. Çelik O, editor. 1. bask›. Istanbul: Turgut Yay›n- c›l›k; 2002. p. 860–89. 10. McGuirt WF. Differantial diagnosis of neck masses. In: Cummings CW, Frederickson JM, Harker LA, Krause CJ, Richardson JM, Harker La, Krause CJ, Richardson MA, Schuller DE, editors. Otolaryngology – head and neck surgery. 3rd ed. St Louis, MI: Mosby Year Book; 1998. p. 1686–99. 11. Kilincalp S, Coban S, Akinci H, et al. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of col- orectal adenocarcinoma. Eur J Cancer Prev 2015;24:328–33. 12. Van Wolfswinkel ME, Vliegenthart-Jongbloed K, de Mendonça Melo M, et al. Predictive value of lymphocytopenia and the neu- trophil-lymphocyte count ratio for severe imported malaria. Malar J 2013;12:1–8. 13. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflam- mation in psoriasis. Cutan Ocul Toxicol 2014;33:223–7. 14. Turak O, Özcan F, Iflleyen A, et al. Usefulness of neutrophil-to- lymphocyte ratio to predict in-hospital outcomes in infective endocarditis. Can J Cardiol 2013;29:1672–8. 15. de Jager CP, Wever PC, Gemen EF, et al. The neutrophil-lym- phocyte count ratio in patients with community-acquired pneu- monia. PLoS One 2012;7:e46561. 16. Terradas R, Grau S, Blanch J, et al. Eosinophil count and neu- trophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One 2012;7: e42860. 17. Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnos- tic value of neutrophil: lymphocyte ratio in adults with suspect- ed acute appendicitis. Acta Chir Belg 2010;110:543–7. 18. Boyraz ‹, Koç B, Boyac› A, Tuto¤lu A, Sarman H, Ozkan H. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti- TNF. Int J Clin Exp Med 2014;7:2912–5. 19. Sula B, Tekin R. Use of hematological parameters in evaluation of treatment efficacy in cutaneous leishmaniasis. Journal of Microbiology and Infectious Diseases 2015;5:167–72. 20. Azab B, Shah N, Akerman M, McGinn JT. Value of platelet/lym- phocyte ratio as a predictor of all-cause mortality after non-ST- elevation myocardial infarction. J Thromb Thrombolysis 2012;34: 326–34. 21. Akarsu S, Kurt ANÇ, Kurt A, Varol ‹, fien Y. Thrombocyte vol- ume parameters in different disease groups. [Article in Turkish] Türk Pediatri Arflivi 2006;41:208–13. 22. Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal 2014;28:245–8.
Yıl 2017, Cilt: 7 Sayı: 2, 99 - 103, 30.09.2017

Öz

Kaynakça

  • Perkins SL, Segal GH, Kjeldsberg CR. Work-up of lym- phadenopathy in children. Semin Diagn Pathol 1995;12:284–7. 2. Twist CJ, Link MP. Assessment of lymphadenopathy in chil- dren. Pediatr Clin North Am 2002;49:1009–25. 3. Locke R, MacGregor F, Kubba H. The validation of an algo- rithm for the management of paediatric cervical lymphadenopa- thy. Int J Pediatr Otorhinolaryngol 2016;81:5–9. 4. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil- lymphocyte count ratio predict bacteremia better than conven- tional infection markers in an emergency care unit. Crit Care 2010;14:R192–5. 5. Zahorec R. Ratio of neutrophil to lymphocyte counts – rapid and simple parameter of systemic inflammation and stress in critical- ly ill. Bratisl Lek Listy 2001;102:5–14. 6. Balta S, Demirkol S, Unlu M, Arslan Z, Celik T. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions. Br J Cancer 2013;109:3125–6. 7. Balta S, Ozturk C, Kurtoglu E. The neutrophil-lymphocyte ratio is not enough to describe inflammatory condition. Eur Arch Otorhinolaryngol 2014;271:1839–40. 8. Demir D, Akçam MT, Karakoç Ö, Öngörü Ö, Yetifler S. Bafl boyun kitlelerinde ince i¤ne aspirasyon biopsisinin tan›sal de¤eri. KBB-Forum 2006;5:5–11. 9. Yalç›n fi. Boyun kitleleri. In: Kulak burun bo¤az hastal›klar› ve bafl boyun cerrahisi. Çelik O, editor. 1. bask›. Istanbul: Turgut Yay›n- c›l›k; 2002. p. 860–89. 10. McGuirt WF. Differantial diagnosis of neck masses. In: Cummings CW, Frederickson JM, Harker LA, Krause CJ, Richardson JM, Harker La, Krause CJ, Richardson MA, Schuller DE, editors. Otolaryngology – head and neck surgery. 3rd ed. St Louis, MI: Mosby Year Book; 1998. p. 1686–99. 11. Kilincalp S, Coban S, Akinci H, et al. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of col- orectal adenocarcinoma. Eur J Cancer Prev 2015;24:328–33. 12. Van Wolfswinkel ME, Vliegenthart-Jongbloed K, de Mendonça Melo M, et al. Predictive value of lymphocytopenia and the neu- trophil-lymphocyte count ratio for severe imported malaria. Malar J 2013;12:1–8. 13. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflam- mation in psoriasis. Cutan Ocul Toxicol 2014;33:223–7. 14. Turak O, Özcan F, Iflleyen A, et al. Usefulness of neutrophil-to- lymphocyte ratio to predict in-hospital outcomes in infective endocarditis. Can J Cardiol 2013;29:1672–8. 15. de Jager CP, Wever PC, Gemen EF, et al. The neutrophil-lym- phocyte count ratio in patients with community-acquired pneu- monia. PLoS One 2012;7:e46561. 16. Terradas R, Grau S, Blanch J, et al. Eosinophil count and neu- trophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One 2012;7: e42860. 17. Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnos- tic value of neutrophil: lymphocyte ratio in adults with suspect- ed acute appendicitis. Acta Chir Belg 2010;110:543–7. 18. Boyraz ‹, Koç B, Boyac› A, Tuto¤lu A, Sarman H, Ozkan H. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti- TNF. Int J Clin Exp Med 2014;7:2912–5. 19. Sula B, Tekin R. Use of hematological parameters in evaluation of treatment efficacy in cutaneous leishmaniasis. Journal of Microbiology and Infectious Diseases 2015;5:167–72. 20. Azab B, Shah N, Akerman M, McGinn JT. Value of platelet/lym- phocyte ratio as a predictor of all-cause mortality after non-ST- elevation myocardial infarction. J Thromb Thrombolysis 2012;34: 326–34. 21. Akarsu S, Kurt ANÇ, Kurt A, Varol ‹, fien Y. Thrombocyte vol- ume parameters in different disease groups. [Article in Turkish] Türk Pediatri Arflivi 2006;41:208–13. 22. Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal 2014;28:245–8.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Saime Güzelsoy Sağıroğlu Bu kişi benim

Selman Sarıca Bu kişi benim

Nagihan Bilal Bu kişi benim

İsrafil Orhan Bu kişi benim

Ayşegül Erdoğan Bu kişi benim

Metin Kılıç Bu kişi benim

Yayımlanma Tarihi 30 Eylül 2017
Gönderilme Tarihi 6 Kasım 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 7 Sayı: 2

Kaynak Göster

APA Güzelsoy Sağıroğlu, S., Sarıca, S., Bilal, N., Orhan, İ., vd. (2017). The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy. ENT Updates, 7(2), 99-103.
AMA Güzelsoy Sağıroğlu S, Sarıca S, Bilal N, Orhan İ, Erdoğan A, Kılıç M. The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy. ENT Updates. Eylül 2017;7(2):99-103.
Chicago Güzelsoy Sağıroğlu, Saime, Selman Sarıca, Nagihan Bilal, İsrafil Orhan, Ayşegül Erdoğan, ve Metin Kılıç. “The Investigation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Children With Pathological Cervical Lymphadenopathy”. ENT Updates 7, sy. 2 (Eylül 2017): 99-103.
EndNote Güzelsoy Sağıroğlu S, Sarıca S, Bilal N, Orhan İ, Erdoğan A, Kılıç M (01 Eylül 2017) The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy. ENT Updates 7 2 99–103.
IEEE S. Güzelsoy Sağıroğlu, S. Sarıca, N. Bilal, İ. Orhan, A. Erdoğan, ve M. Kılıç, “The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy”, ENT Updates, c. 7, sy. 2, ss. 99–103, 2017.
ISNAD Güzelsoy Sağıroğlu, Saime vd. “The Investigation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Children With Pathological Cervical Lymphadenopathy”. ENT Updates 7/2 (Eylül 2017), 99-103.
JAMA Güzelsoy Sağıroğlu S, Sarıca S, Bilal N, Orhan İ, Erdoğan A, Kılıç M. The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy. ENT Updates. 2017;7:99–103.
MLA Güzelsoy Sağıroğlu, Saime vd. “The Investigation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Children With Pathological Cervical Lymphadenopathy”. ENT Updates, c. 7, sy. 2, 2017, ss. 99-103.
Vancouver Güzelsoy Sağıroğlu S, Sarıca S, Bilal N, Orhan İ, Erdoğan A, Kılıç M. The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy. ENT Updates. 2017;7(2):99-103.