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Differential diagnosis of submandibular gland swellings

Yıl 2018, Cilt: 8 Sayı: 1, 56 - 61, 05.04.2018

Öz

Objective: The differential diagnosis of
submandibular triangle swellings can be challenging to the clinician. In
this study, we retrospectively analyzed clinical and histopathological
characteristics of these swellings referred to our clinic and integrated
our results with current literature in terms of various diagnostic
aspects.




Methods: A
total number of 64 transcervical submandibular gland extirpations were
reviewed and evaluated regarding age, gender, fine-needle aspiration
biopsy and specimen reports




Results:
This study comprised 34 male (53.1%) and 30 female (46.9%) patients. We
classified submandibular triangle swellings clinicopathologically as
tumoral and non-tumoral lesions for better evaluation. We had 15
patients with primary epithelial submandibular gland neoplasm, 10
(66.7%) of them were benign cases, all of the benign cases were
pleomorphic adenoma with a male to female ratio of 1:2.33 and a mean age
of 30.8 years, 5 (33.3%) of them were malignant with a mean age of 55
years. There were also 37(57.8%) patients with chronic sialadenitis
associated with sialolithasis, 1 (1.6%) had acute sialedenitis, 2 (3.1%)
had granulomatous sialadenitis, 2 (3.1%) had reactive cervical
lymphadenopathy and 5 (7.8%) were treated for cystic lesion removal.
Ultrasonography and fine needle aspiration cytology were our major
diagnostic tools for differential diagnosis. Our institution's
sensitivity of fine-needle aspiration cytology for identifying
malignancy was 60% and the specificity was 100%.




Conclusion:
Submandibular gland excision for primary lesions has relatively low
incidence compared with other surgical implications. Although chronic
sialadenitis caused by symptomatic sialolithiasisis the most frequent
indication for surgery, diverse clinical entities should be ruled out
for differential diagnosis of swellings of this region.

Kaynakça

  • 1. Preuss S, Klussmann J, Wittekindt C, Drebber U, Beutner D, Guntinas-Lichius O. Submandibular gland excision: 15 years of experience. J Oral Maxillofac Surg 2007;65:953–7. 2. Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986;8:177–84. 3. Kalinowski M, Heverhagen JT, Rehberg E, Klose KJ, Wagner HJ. Comparative study of MR sialography and digital subtraction sialography for benign salivary gland disorders. AJNR Am J Neuroradiol 2002;23:1485–92. 4. Goncalves M, Schapher M, Iro H, Wuest W, Mantsopoulos K, Koch M. Value of sonography in the diagnosis of sialolithiasis: comparison with the reference standard of direct stone identifica- tion. J Ultrasound Med 2017;36:2227–35. 5. Thomas WW, Douglas JE, Rassekh CH. Accuracy of ultrasonog- raphy and computed tomography in the evaluation of patients undergoing sialendoscopy for sialolithiasis. Otolaryngol Head Neck Surg 2017;156:834–9. 6. Feinstein AJ, Alonso J, Yang SE, St John M. Diagnostic accuracy of fine-needle aspiration for parotid and submandibular gland lesions. Otolaryngol Head Neck Surg 2016;155:431–6. 7. Barnes L, Eveson JW, Reichart P, Sidransky D (Eds.). World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. 8. Dalgic A, Karakoc O, Karahatay S, et al. Submandibular triangle masses. J Craniofac Surg 2013;24:e529–31. 9. Kumar T, Puri G, Aravinda K, et al. Submandibular swelling: a case report with differential diagnosis. Universal Research Journal of Dentistry 2015;5:103–6. 10. Papaspyrou G, Werner JA, Sesterhenn AM. Transcervical extirpa- tion of the submandibular gland: the University of Marburg expe- rience. Eur Arch Otorhinolaryngol 2014;271:2009–12. 11. ‹riz A, Aç›kal›n A, Acar A, Boynue¤ri S, Ery›lmaz A. Submandibular bez kitlelerine yaklafl›m›m›z. Kulak Burun Bo¤az ve Bafl Boyun Cerrahisi Dergisi 2011;19:66-9. 12. Lustmann J, Regev E, Melamed Y. Sialolithiasis. A survey on 245 patients and a review of the literature. Int J Oral Maxillofac Surg 1990;19:135–8. 13. Huoh KC, Eisele DW. Etiologic factors in sialolithiasis. Otolaryngol Head Neck Surg 2011;145:935–9. 14. Adlkofer F, Thurau K. Effects of nicotine on biological systems. Basel, Switzerland: Birkhauser Verlag; 1991. 15. Mela F, Berrone S, Giordano M. Clinico-statistical considerations of submandibular sialolithiasis. [Article in Italian] Minerva Stomatol 1986;35:571–3. 16. McKenna J, Bostock D, McMenamin PG. Sialolithiasis. Am Fam Physician 1987;36:119–25. 17. Díaz KP, Gerhard R, Domingues RB, et al. High diagnostic accu- racy and reproducibility of fine-needle aspiration cytology for diagnosing salivary gland tumors: cytohistologic correlation in 182 cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118:226– 35. 18. P A, C A, Masilamani S, Jonathan S. Diagnosis of salivary gland lesions by fine needle aspiration cytology and its histopathological correlation in a tertiary care center of southern India. J Clin Diagn Res 2015;9:EC07–10. 19. Weber RS, Byers RM, Petit B, Wolf P, Ang K, Luna M. Submandibular gland tumors. Adverse histologic factors and ther- apeutic implications. Arch Otolaryngol Head Neck Surg 1990;116: 1055–60. 20. Camilleri IG, Malata CM, McLean NR, Kelly CG. Malignant tumours of the submandibular salivary gland: a 15-year review. Br J Plast Surg 1998;51:181–5. 21. Layfield LJ, Gopez EV. Cystic lesions of the salivary glands: cyto- logic features in fine-needle aspiration biopsies. Diagn Cytopathol 2002;27:197–204. 22. Orell SR, Nettle WJS. Fine needle aspiration biopsy of salivary gland tumours. Problems and pitfalls. Pathology 1988;20:332–7. 23. Batsakis JG. Granulomatous sialadenitis. Ann Otol Rhinol Laryngol 1991;100:166–9. 24. van der Walt JD, Leake J. Granulomatous sialadenitis of the major salivary glands. A clinicopathological study of 57 cases. Histopathol- ogy 1987;11:132–44. 25. Abuel-Haija M, Czader M. Salivary gland lymphomas. In: Al- Abbadi MA, editor. Salivary gland cytology. New York: Wiley? Blackwell; 2011. p. 187–214. 26. Gleeson MJ, Bennett MH, Cawson RA. Lymphomas of salivary glands. Cancer 1986;58:699–704. 27. Hernando M, Echarri RM, Taha M, Martin-Fragueiro L, Hernando A, Mayor GP. Surgical complications of submandibular gland excision. Acta Otorrinolaringol Esp 2012;63:42–6.
Yıl 2018, Cilt: 8 Sayı: 1, 56 - 61, 05.04.2018

Öz

Kaynakça

  • 1. Preuss S, Klussmann J, Wittekindt C, Drebber U, Beutner D, Guntinas-Lichius O. Submandibular gland excision: 15 years of experience. J Oral Maxillofac Surg 2007;65:953–7. 2. Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986;8:177–84. 3. Kalinowski M, Heverhagen JT, Rehberg E, Klose KJ, Wagner HJ. Comparative study of MR sialography and digital subtraction sialography for benign salivary gland disorders. AJNR Am J Neuroradiol 2002;23:1485–92. 4. Goncalves M, Schapher M, Iro H, Wuest W, Mantsopoulos K, Koch M. Value of sonography in the diagnosis of sialolithiasis: comparison with the reference standard of direct stone identifica- tion. J Ultrasound Med 2017;36:2227–35. 5. Thomas WW, Douglas JE, Rassekh CH. Accuracy of ultrasonog- raphy and computed tomography in the evaluation of patients undergoing sialendoscopy for sialolithiasis. Otolaryngol Head Neck Surg 2017;156:834–9. 6. Feinstein AJ, Alonso J, Yang SE, St John M. Diagnostic accuracy of fine-needle aspiration for parotid and submandibular gland lesions. Otolaryngol Head Neck Surg 2016;155:431–6. 7. Barnes L, Eveson JW, Reichart P, Sidransky D (Eds.). World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. 8. Dalgic A, Karakoc O, Karahatay S, et al. Submandibular triangle masses. J Craniofac Surg 2013;24:e529–31. 9. Kumar T, Puri G, Aravinda K, et al. Submandibular swelling: a case report with differential diagnosis. Universal Research Journal of Dentistry 2015;5:103–6. 10. Papaspyrou G, Werner JA, Sesterhenn AM. Transcervical extirpa- tion of the submandibular gland: the University of Marburg expe- rience. Eur Arch Otorhinolaryngol 2014;271:2009–12. 11. ‹riz A, Aç›kal›n A, Acar A, Boynue¤ri S, Ery›lmaz A. Submandibular bez kitlelerine yaklafl›m›m›z. Kulak Burun Bo¤az ve Bafl Boyun Cerrahisi Dergisi 2011;19:66-9. 12. Lustmann J, Regev E, Melamed Y. Sialolithiasis. A survey on 245 patients and a review of the literature. Int J Oral Maxillofac Surg 1990;19:135–8. 13. Huoh KC, Eisele DW. Etiologic factors in sialolithiasis. Otolaryngol Head Neck Surg 2011;145:935–9. 14. Adlkofer F, Thurau K. Effects of nicotine on biological systems. Basel, Switzerland: Birkhauser Verlag; 1991. 15. Mela F, Berrone S, Giordano M. Clinico-statistical considerations of submandibular sialolithiasis. [Article in Italian] Minerva Stomatol 1986;35:571–3. 16. McKenna J, Bostock D, McMenamin PG. Sialolithiasis. Am Fam Physician 1987;36:119–25. 17. Díaz KP, Gerhard R, Domingues RB, et al. High diagnostic accu- racy and reproducibility of fine-needle aspiration cytology for diagnosing salivary gland tumors: cytohistologic correlation in 182 cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118:226– 35. 18. P A, C A, Masilamani S, Jonathan S. Diagnosis of salivary gland lesions by fine needle aspiration cytology and its histopathological correlation in a tertiary care center of southern India. J Clin Diagn Res 2015;9:EC07–10. 19. Weber RS, Byers RM, Petit B, Wolf P, Ang K, Luna M. Submandibular gland tumors. Adverse histologic factors and ther- apeutic implications. Arch Otolaryngol Head Neck Surg 1990;116: 1055–60. 20. Camilleri IG, Malata CM, McLean NR, Kelly CG. Malignant tumours of the submandibular salivary gland: a 15-year review. Br J Plast Surg 1998;51:181–5. 21. Layfield LJ, Gopez EV. Cystic lesions of the salivary glands: cyto- logic features in fine-needle aspiration biopsies. Diagn Cytopathol 2002;27:197–204. 22. Orell SR, Nettle WJS. Fine needle aspiration biopsy of salivary gland tumours. Problems and pitfalls. Pathology 1988;20:332–7. 23. Batsakis JG. Granulomatous sialadenitis. Ann Otol Rhinol Laryngol 1991;100:166–9. 24. van der Walt JD, Leake J. Granulomatous sialadenitis of the major salivary glands. A clinicopathological study of 57 cases. Histopathol- ogy 1987;11:132–44. 25. Abuel-Haija M, Czader M. Salivary gland lymphomas. In: Al- Abbadi MA, editor. Salivary gland cytology. New York: Wiley? Blackwell; 2011. p. 187–214. 26. Gleeson MJ, Bennett MH, Cawson RA. Lymphomas of salivary glands. Cancer 1986;58:699–704. 27. Hernando M, Echarri RM, Taha M, Martin-Fragueiro L, Hernando A, Mayor GP. Surgical complications of submandibular gland excision. Acta Otorrinolaringol Esp 2012;63:42–6.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Demet Yazıcı

Mehmet Yalçın Çöktü Bu kişi benim

Zekiye Güney Bu kişi benim

Sanem Okşan Erkan Bu kişi benim

Orhan Görgülü Bu kişi benim

İlhami Yıldırım Bu kişi benim

Osman Kürşat Arıkan Bu kişi benim

Yayımlanma Tarihi 5 Nisan 2018
Gönderilme Tarihi 13 Ocak 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 8 Sayı: 1

Kaynak Göster

APA Yazıcı, D., Çöktü, M. Y., Güney, Z., Erkan, S. O., vd. (2018). Differential diagnosis of submandibular gland swellings. ENT Updates, 8(1), 56-61.
AMA Yazıcı D, Çöktü MY, Güney Z, Erkan SO, Görgülü O, Yıldırım İ, Arıkan OK. Differential diagnosis of submandibular gland swellings. ENT Updates. Nisan 2018;8(1):56-61.
Chicago Yazıcı, Demet, Mehmet Yalçın Çöktü, Zekiye Güney, Sanem Okşan Erkan, Orhan Görgülü, İlhami Yıldırım, ve Osman Kürşat Arıkan. “Differential Diagnosis of Submandibular Gland Swellings”. ENT Updates 8, sy. 1 (Nisan 2018): 56-61.
EndNote Yazıcı D, Çöktü MY, Güney Z, Erkan SO, Görgülü O, Yıldırım İ, Arıkan OK (01 Nisan 2018) Differential diagnosis of submandibular gland swellings. ENT Updates 8 1 56–61.
IEEE D. Yazıcı, M. Y. Çöktü, Z. Güney, S. O. Erkan, O. Görgülü, İ. Yıldırım, ve O. K. Arıkan, “Differential diagnosis of submandibular gland swellings”, ENT Updates, c. 8, sy. 1, ss. 56–61, 2018.
ISNAD Yazıcı, Demet vd. “Differential Diagnosis of Submandibular Gland Swellings”. ENT Updates 8/1 (Nisan 2018), 56-61.
JAMA Yazıcı D, Çöktü MY, Güney Z, Erkan SO, Görgülü O, Yıldırım İ, Arıkan OK. Differential diagnosis of submandibular gland swellings. ENT Updates. 2018;8:56–61.
MLA Yazıcı, Demet vd. “Differential Diagnosis of Submandibular Gland Swellings”. ENT Updates, c. 8, sy. 1, 2018, ss. 56-61.
Vancouver Yazıcı D, Çöktü MY, Güney Z, Erkan SO, Görgülü O, Yıldırım İ, Arıkan OK. Differential diagnosis of submandibular gland swellings. ENT Updates. 2018;8(1):56-61.