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TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019

Yıl 2023, Cilt: 4 Sayı: 1, 11 - 16, 29.03.2023
https://doi.org/10.48176/esmj.2023.97

Öz

Introduction: Heart failure is the third most common cause of death after coronary artery disease and stroke. If we monitor the mortality of such a fatal disease, we can control the disease more in our study. Therefore, we aimed to create a mortality trend by taking the data of deaths due to heart failure in Turkiye in the last ten years.
Methods: We obtained population estimates for Turkey from the TurkStat website. Age- and sex-specific and age-standardized rates (ASRs, using the World standard population and the method of direct standardization) were calculated. Mortality trends from heart failure were assessed using the Joinpoint regression analysis. Statistical analysis was carried out with the Joinpoint software, version 4.9.0.0. We considered p values less than 0.05 to be statistically significant.
Results: We found Turkey's 10-year standardized mortality rate is 20.63%. The highest mortality rate is in the western Marmara; the lowest one is Eastern Karadeniz. We observed a significant increase in mortality at 10 years in the total population.(p:0,008). We detected a significant growth between 2009 and 2016 (p< 0.001) and a significant decrease after 2016 (p:0.047)
Conclusion: We obtained standardized mortality rates of heart failure patients in Turkey between 2009 and 2019 according to age, sex and years. We showed the overall mortality reduction after 2016.

Kaynakça

  • 1. Yilmaz MB, Çelik A, Çavusoglu Y, Bekar L, Onrat E, et al. Snapshot evaluation of heart failure in Turkey: Baseline characteristics of SELFIE-TR. Turk Kardiyol Dern Ars 2019; 47: 198–206. doi:10.5543/TKDA.2019.66877
  • 2. Değertekin M, Erol C, Ergene O, Tokgözoğlu L, Aksoy M, Erol MK, et al. Heart failure prevalence and predictors in Turkey: HAPPY study. Turk Kardiyol Dern Ars 2012; 40: 298-308.
  • 3. Yılmaz MB, Aksakal E, Aksu U, Altay H, Yıldırım N, Çelik A, et al. Snapshot evaluation of acute and chronic heart failure in real-life in Turkey: A follow-up data for mortality. Anatol J Cardiol 2020; 23:160–8. doi:10.14744/AnatolJCardiol.2019.87894
  • 4. Türkiye İstatistik Kurumu (TÜİK) [Internet].. Available from: https://www.tuik.gov.tr/
  • 5. Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization 2001; 9.
  • 6. Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000; 19: 335-51.
  • 7. Kim HJ, Luo J, Chen HS, Green D, Buckman D, Byrne J, et al. Improved confidence interval for average annual percent change in trend analysis. Stat Med 2017; 36: 3059–74. doi:10.1002/SIM.7344
  • 8. Clegg LX, Hankey BF, Tiwari R, Feuer EJ, Edwards BK. Estimating average annual per cent change in trend analysis. Stat Med 2009; 28: 3670–82. doi:10.1002/SIM.3733
  • 9. Kim HJ, Fay MP, Yu B, Barrett MJ, Feuer EJ. Comparability of segmented line regression models. Biometrics 2004; 60: 1005–14. doi:10.1111/J.0006-341X.2004.00256.X
  • 10. Ziaeian B, Fonarow GC. Epidemiology and etiology of heart failure. Nat Rev Cardiol 2016; 13: 368–78. doi:10.1038/NRCARDIO.2016.25
  • 11. Akintoye E, Briasoulis A, Egbe A, Dunlay SM, Kushwaha S, Levine D, et al. National Trends in Admission and In‐Hospital Mortality of Patients With Heart Failure in the United States (2001–2014). J Am Hear Assoc Cardiovasc Cerebrovasc Dis 2017; 6. doi:10.1161/JAHA.117.006955
  • 12. Members WC, Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult—Summary Article. Circulation 2005;112: 1825–52. doi:10.1161/CIRCULATIONAHA.105.167587
  • 13. Shiraishi Y, Kohsaka S, Sato N, Takano T, Kitai T, Yoshikawa T, et al. 9‐Year Trend in the Management of Acute Heart Failure in Japan: A Report From the National Consortium of Acute Heart Failure Registries. J Am Hear Assoc Cardiovasc Cerebrovasc Dis 2018;7. doi:10.1161/JAHA.118.008687
  • 14. Schmidt M, Ulrichsen SP, Pedersen L, Bøtker HE, Sørensen HT. Thirty-year trends in heart failure hospitalization and mortality rates and the prognostic impact of co-morbidity: a Danish nationwide cohort study. Eur J Heart Fail; 18: 490–9. doi:10.1002/EJHF.486
  • 15. Barasa A, Schaufelberger M, Lappas G, Swedberg K, Dellborg M, Rosengren A. Editor's choice: Heart failure in young adults: 20-year trends in hospitalization, etiology, and case fatality in Sweden. Eur Heart J 2014; 35: 25. doi:10.1093/EURHEARTJ/EHT278
  • 16. Crespo-Leiro MG, Anker SD, Maggioni AP, Coats AJ, Filippatos G, Ruschitzka F, et al. European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. Eur J Heart Fail 2016; 18: 613–25. doi:10.1002/ejhf.566
  • 17. Jhund PS, MacIntyre K, Simpson CR, Lewsey JD, Stewart S, Redpath A, et al. Long-term trends in the first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people. Circulation 2009; 119: 515–23. doi:10.1161/CIRCULATIONAHA.108.812172
  • 18. Mosterd A, Reitsma JB, Grobbee DE. Angiotensin converting enzyme inhibition and hospitalisation rates for heart failure in the Netherlands, 1980 to 1999: the end of an epidemic? Heart 2002; 87:75-6.
  • 19. Márquez-Calderón S, Pérez Velasco L, Viciana-Fernández F, Fernández Merino JC. Trends in age-sex-specific mortality in Spain (1981-2016). Changes associated with the economic crisis. Gac Sanit 2020; 34: 230–7. doi:10.1016/J.GACETA.2019.03.007
  • 20. Yılmaz MB, Aksakal E, Aksu U, Altay H, Nesligül Y, Çelik A, et al. Snapshot evaluation of acute and chronic heart failure in real-life in Turkey: A follow-up data for mortality. Anatol J Cardiol 2020; 23: 160-8. doi:10.5543/tkda.2019.66877
  • 21. Gürsel G, Levent E, Öztürk C, Karalezli A. Hospital based survey of lung cancer in Turkey, a developing country, where smoking is highly prevalent. Lung Cancer 1998; 21: 127-32.
  • 22. Çavuşoğlu Y, Zoghi M, Eren M, Bozçalı E, Kozdağ G, Şentürk T, et al. Post-discharge heart failure monitoring program in Turkey: Hit-PoinT. Anatol J Cardiol 2017; 17:107. doi:10.14744/ANATOLJCARDIOL.2016.6812
  • 23. Ekici B, Yaman M, Küçük M, Dereli S, Yenerçaǧ M, Yiǧit Z, et al. Angiotensin receptor neprilysin inhibitor for patients with heart failure and reduced ejection fraction: Real-world experience from Turkey (ARNi-TR). Turk Kardiyol Dern Ars 2021; 49: 357–67. doi:10.5543/TKDA.2021.63099
  • 24. Işeri A, Arslan N. Obesity in adults in Turkey: age and regional effects. Eur J Public Health. 2009; 19: 91–4. doi:10.1093/EURPUB/CKN107
  • 25. Gök G, Sinan ÜY, Özyüncü N, Zoghi M. The prevalence of cardiovascular diseases, risk factors, and cardiovascular drug therapy in very elderly Turkish patients admitted to cardiology clinics: A subgroup analysis of the ELDER-TURK study ELDER-TÜRK Investigators. Turk Kardiyol Dern Ars 2018; 46: 283–95. doi:10.5543/tkda.2018.49579
  • 26. Tatar M, Mollahaliloglu S, Sahin B. et al. Turkey: health system review.World Health Organization ‎2011‎; 1817-6127: 186.

TÜRKİYE KALP YETMEZLİĞİ MORTALİTE TRENDİ, 2009-2019

Yıl 2023, Cilt: 4 Sayı: 1, 11 - 16, 29.03.2023
https://doi.org/10.48176/esmj.2023.97

Öz

Giriş: Kalp yetmezliği, koroner arter hastalığı ve inmeden sonra en sık üçüncü ölüm nedenidir. Bu denli mortalitesi yüksek bir hastalığı kontrol altına alabilmek için öncelikle ölüm oranlarını bilmek gerekir. Biz çalışmamızda Türkiye'de son on yılda kalp yetmezliğine bağlı ölümlerin verilerini alarak bir mortalite trendi oluşturmayı hedefledik.
Yöntemler: Türkiye için nüfus tahminlerini TÜİK web sitesinden elde ettik. Yaşa ve cinsiyete özel ve yaşa göre standardize edilmiş oranlar (Dünya standart popülasyonu ve doğrudan standardizasyon yöntemi kullanılarak ASR'ler) hesaplandı. Kalp yetmezliğinden ölüm eğilimleri Joinpoint regresyon analizi kullanılarak değerlendirildi. İstatistiksel analiz, Joinpoint yazılımı 4.9.0.0 sürümü ile gerçekleştirildi. 0,05'ten küçük p değerleri istatistiksel olarak anlamlı kabul edildi
Bulgular: Türkiye'nin 10 yıllık standardize ölüm oranını %20.63 olarak bulduk. En yüksek ölüm oranı batı Marmara'da; en düşük oran Doğu Karadeniz’dedir. Toplam popülasyonda 10 yılda mortalitede önemli bir artış gözlemledik(p:0,008). 2009-2016 yılları arasında önemli bir artış (p< 0.001) ve 2016 sonrası önemli bir düşüş (p:0.047) tespit ettik.
Sonuç: 2009-2019 yılları arasında Türkiye'deki kalp yetmezliği hastalarının yaş, cinsiyet ve yıllara göre standartlaştırılmış ölüm hızlarını elde ettik. 2016'dan sonra kalp yetmezliğinin genel mortalite düşme eğilimindedir.
Anahtar Kelimeler: Kalp Yetmezliği, Türkiye, Mortalite

Kaynakça

  • 1. Yilmaz MB, Çelik A, Çavusoglu Y, Bekar L, Onrat E, et al. Snapshot evaluation of heart failure in Turkey: Baseline characteristics of SELFIE-TR. Turk Kardiyol Dern Ars 2019; 47: 198–206. doi:10.5543/TKDA.2019.66877
  • 2. Değertekin M, Erol C, Ergene O, Tokgözoğlu L, Aksoy M, Erol MK, et al. Heart failure prevalence and predictors in Turkey: HAPPY study. Turk Kardiyol Dern Ars 2012; 40: 298-308.
  • 3. Yılmaz MB, Aksakal E, Aksu U, Altay H, Yıldırım N, Çelik A, et al. Snapshot evaluation of acute and chronic heart failure in real-life in Turkey: A follow-up data for mortality. Anatol J Cardiol 2020; 23:160–8. doi:10.14744/AnatolJCardiol.2019.87894
  • 4. Türkiye İstatistik Kurumu (TÜİK) [Internet].. Available from: https://www.tuik.gov.tr/
  • 5. Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization 2001; 9.
  • 6. Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000; 19: 335-51.
  • 7. Kim HJ, Luo J, Chen HS, Green D, Buckman D, Byrne J, et al. Improved confidence interval for average annual percent change in trend analysis. Stat Med 2017; 36: 3059–74. doi:10.1002/SIM.7344
  • 8. Clegg LX, Hankey BF, Tiwari R, Feuer EJ, Edwards BK. Estimating average annual per cent change in trend analysis. Stat Med 2009; 28: 3670–82. doi:10.1002/SIM.3733
  • 9. Kim HJ, Fay MP, Yu B, Barrett MJ, Feuer EJ. Comparability of segmented line regression models. Biometrics 2004; 60: 1005–14. doi:10.1111/J.0006-341X.2004.00256.X
  • 10. Ziaeian B, Fonarow GC. Epidemiology and etiology of heart failure. Nat Rev Cardiol 2016; 13: 368–78. doi:10.1038/NRCARDIO.2016.25
  • 11. Akintoye E, Briasoulis A, Egbe A, Dunlay SM, Kushwaha S, Levine D, et al. National Trends in Admission and In‐Hospital Mortality of Patients With Heart Failure in the United States (2001–2014). J Am Hear Assoc Cardiovasc Cerebrovasc Dis 2017; 6. doi:10.1161/JAHA.117.006955
  • 12. Members WC, Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult—Summary Article. Circulation 2005;112: 1825–52. doi:10.1161/CIRCULATIONAHA.105.167587
  • 13. Shiraishi Y, Kohsaka S, Sato N, Takano T, Kitai T, Yoshikawa T, et al. 9‐Year Trend in the Management of Acute Heart Failure in Japan: A Report From the National Consortium of Acute Heart Failure Registries. J Am Hear Assoc Cardiovasc Cerebrovasc Dis 2018;7. doi:10.1161/JAHA.118.008687
  • 14. Schmidt M, Ulrichsen SP, Pedersen L, Bøtker HE, Sørensen HT. Thirty-year trends in heart failure hospitalization and mortality rates and the prognostic impact of co-morbidity: a Danish nationwide cohort study. Eur J Heart Fail; 18: 490–9. doi:10.1002/EJHF.486
  • 15. Barasa A, Schaufelberger M, Lappas G, Swedberg K, Dellborg M, Rosengren A. Editor's choice: Heart failure in young adults: 20-year trends in hospitalization, etiology, and case fatality in Sweden. Eur Heart J 2014; 35: 25. doi:10.1093/EURHEARTJ/EHT278
  • 16. Crespo-Leiro MG, Anker SD, Maggioni AP, Coats AJ, Filippatos G, Ruschitzka F, et al. European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. Eur J Heart Fail 2016; 18: 613–25. doi:10.1002/ejhf.566
  • 17. Jhund PS, MacIntyre K, Simpson CR, Lewsey JD, Stewart S, Redpath A, et al. Long-term trends in the first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people. Circulation 2009; 119: 515–23. doi:10.1161/CIRCULATIONAHA.108.812172
  • 18. Mosterd A, Reitsma JB, Grobbee DE. Angiotensin converting enzyme inhibition and hospitalisation rates for heart failure in the Netherlands, 1980 to 1999: the end of an epidemic? Heart 2002; 87:75-6.
  • 19. Márquez-Calderón S, Pérez Velasco L, Viciana-Fernández F, Fernández Merino JC. Trends in age-sex-specific mortality in Spain (1981-2016). Changes associated with the economic crisis. Gac Sanit 2020; 34: 230–7. doi:10.1016/J.GACETA.2019.03.007
  • 20. Yılmaz MB, Aksakal E, Aksu U, Altay H, Nesligül Y, Çelik A, et al. Snapshot evaluation of acute and chronic heart failure in real-life in Turkey: A follow-up data for mortality. Anatol J Cardiol 2020; 23: 160-8. doi:10.5543/tkda.2019.66877
  • 21. Gürsel G, Levent E, Öztürk C, Karalezli A. Hospital based survey of lung cancer in Turkey, a developing country, where smoking is highly prevalent. Lung Cancer 1998; 21: 127-32.
  • 22. Çavuşoğlu Y, Zoghi M, Eren M, Bozçalı E, Kozdağ G, Şentürk T, et al. Post-discharge heart failure monitoring program in Turkey: Hit-PoinT. Anatol J Cardiol 2017; 17:107. doi:10.14744/ANATOLJCARDIOL.2016.6812
  • 23. Ekici B, Yaman M, Küçük M, Dereli S, Yenerçaǧ M, Yiǧit Z, et al. Angiotensin receptor neprilysin inhibitor for patients with heart failure and reduced ejection fraction: Real-world experience from Turkey (ARNi-TR). Turk Kardiyol Dern Ars 2021; 49: 357–67. doi:10.5543/TKDA.2021.63099
  • 24. Işeri A, Arslan N. Obesity in adults in Turkey: age and regional effects. Eur J Public Health. 2009; 19: 91–4. doi:10.1093/EURPUB/CKN107
  • 25. Gök G, Sinan ÜY, Özyüncü N, Zoghi M. The prevalence of cardiovascular diseases, risk factors, and cardiovascular drug therapy in very elderly Turkish patients admitted to cardiology clinics: A subgroup analysis of the ELDER-TURK study ELDER-TÜRK Investigators. Turk Kardiyol Dern Ars 2018; 46: 283–95. doi:10.5543/tkda.2018.49579
  • 26. Tatar M, Mollahaliloglu S, Sahin B. et al. Turkey: health system review.World Health Organization ‎2011‎; 1817-6127: 186.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makaleleri
Yazarlar

İbrahim Etem Dural 0000-0003-4005-4858

Nurhan Dogan 0000-0001-7224-6091

Yayımlanma Tarihi 29 Mart 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 4 Sayı: 1

Kaynak Göster

APA Dural, İ. E., & Dogan, N. (2023). TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019. Eskisehir Medical Journal, 4(1), 11-16. https://doi.org/10.48176/esmj.2023.97
AMA Dural İE, Dogan N. TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019. Eskisehir Med J. Mart 2023;4(1):11-16. doi:10.48176/esmj.2023.97
Chicago Dural, İbrahim Etem, ve Nurhan Dogan. “TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019”. Eskisehir Medical Journal 4, sy. 1 (Mart 2023): 11-16. https://doi.org/10.48176/esmj.2023.97.
EndNote Dural İE, Dogan N (01 Mart 2023) TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019. Eskisehir Medical Journal 4 1 11–16.
IEEE İ. E. Dural ve N. Dogan, “TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019”, Eskisehir Med J, c. 4, sy. 1, ss. 11–16, 2023, doi: 10.48176/esmj.2023.97.
ISNAD Dural, İbrahim Etem - Dogan, Nurhan. “TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019”. Eskisehir Medical Journal 4/1 (Mart 2023), 11-16. https://doi.org/10.48176/esmj.2023.97.
JAMA Dural İE, Dogan N. TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019. Eskisehir Med J. 2023;4:11–16.
MLA Dural, İbrahim Etem ve Nurhan Dogan. “TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019”. Eskisehir Medical Journal, c. 4, sy. 1, 2023, ss. 11-16, doi:10.48176/esmj.2023.97.
Vancouver Dural İE, Dogan N. TRENDS IN BURDEN OF HEART FAILURE MORTALITY IN TURKEY, 2009-2019. Eskisehir Med J. 2023;4(1):11-6.