Cellular Variant Cerebellar Hemangioblastoma: A Case Report

Yıl 2024, Cilt: 5 Sayı: 3, 122 - 124, 30.11.2024

Ömer Polat , Bartu Soysal , Hamza Karabudak , Bengü Göksular , Canberk Topuz , Barıs Chouseın , Gülşah Özdemir , Ebru Taştekin

Öz

Hemangioblastoma is a highly vascularized, have a slow-growing rate grade 1 tumor which are containing neoplastic stromal cells with clear, vacuolated cytoplasm and diagnosed with specific immunohistochemical staining features. Hemangioblastomas can occur in the brain, spinal cord or retina and they account for about 1-2.5% of all intracranial tumors. We presented a 36-year-old male patient presented with a headache and glaucoma. In the radiological images, a cerebellar mass was observed in the localization of the right middle cerebellar pedincle. After surgical resection pathological evaluation was done and as a result, the patient was diagnosed as cellular hemangioblastoma. He was followed up in the intensive care unit for about two months and unfortunately died due to the cardiopulmonary arrest associated with non-tumoral reasons. This case report was a descriptive example for a rare variant of a rare cerebellar tumors

Anahtar Kelimeler

hemangioblastoma, cerebellum, vascular neoplasm

Etik Beyan

In the preparation of this report, the confidentiality and confidentiality of the patient was protected at the highest level and the principles of medical ethics were fully complied with. Since the patient died, the necessary consent was obtained from his relatives.

Hücresel Varyantlı Serebellar Hemangioblastoma: Bir Olgu Sunumu

Öz

Hemanjioblastom oldukça vaskülarize, yavaş büyüyen, berrak, vakuollü sitoplazma ve spesifik immünohistokimyasal boyama özellikleri ile tanı koyulan, neoplastik stromal hücreler içeren derece 1 tümörlerdir. Hemanjiyoblastomlar beyinde, omurilikte veya retinada ortaya çıkabilir ve tüm intrakranyal tümörlerin yaklaşık %1-2,5' unu oluşturur. Baş ağrısı ve glokom şikayetiyle hastanemize başvuran 36 yaşında erkek hastayı sunduk. Hastanın radyolojik görüntülerinde sağ posterior fossada lokalize beyin kitlesi görüldü. Cerrahi rezeksiyon sonrası patolojik değerlendirme yapıldı ve hastaya selüler hemanjiyoblastom tanısı konuldu. Yaklaşık iki ay kadar yoğun bakımda takip edilen hasta maalesef tümör dışı nedenlere bağlı kalp-akciğer durması nedeniyle hayatını kaybetti.

Anahtar Kelimeler

Hemanjiyoblastom, serebellum, vasküler neoplazm

Kaynakça

• 1. Louis DN, Perry A, Wesseling P, et al. Central Nervous System Tumours, WHO Classification of Tumours. Pathology 2021;6:1-15.
• 2. Mondal, D. Nervous System Hemangioblastoma. In: Mallick, S., Giridhar, P., Rath, G.K., editors Evidence Based Practice in Neuro-oncology. Singapore. Springer; 2021, p 249-52.
• 3. Kuharic M, Jankovic D, Splavski B, Arnoutovic KI. Hemangioblastomas of the posterior cranial fossa in adults: demographics, clinical, morphologic, pathologic, surgical features, and outcomes: A systematic review. World Neurosurgery 2018;110:1049-62.
• 4. Yin X, Duan H, Yi Z, Li C, Lu R, Li L. Incidence, prognostic factors and survival for hemangioblastoma of the central nervous system: analysis based on the surveillance, epidemiology, and end results database. Frontiers in Oncology 2020;10:570103.
• 5. Nguyen HS, Doan NB, Gelsomino M, et al. Intracranial hemangioblastoma: A SEER-based analysis 2004-2013. Oncotarget 2018;9:28009-15.
• 6. Lahkim M, Andour H, Laamrani FZ, et al. Cerebellar hemangioblastoma: Case report with review of the literature. Radiology Case Reports 2021;16:3109-12.
• 7. Wang Z, Hu J, Xu L, Malaguit J, Chen S. Intratumoral hemorrhage in a patient with cerebellar hemangioblastoma: a case report and review. Medicine 2015;4:e497.
• 8. Hasselblatt M, Jeibmann A, Gerss J, et al. Cellular and reticular variants of hemangioblastoma revisited: a clinicopathologic study of 88 cases. Neuropathology and Applied Neurobiology 2005;31:618-22.
• 9. Acikalin MF, Öner Ü, Tel N, Pasaoglu Ö, Altınel F. Supratentorial hemangioblastoma: a case report and review of the literature. Archives of Pathology & Laboratory Medicine 2003;9:e382-4.