POLYPHARMACY EXPERIENCE IN GERIATRIC HEMATOLOGY

Yıl 2024, Cilt: 5 Sayı: 3, 86 - 91, 30.11.2024

Abdulkadir Karısmaz , Istemi Serın , Ceyda Aslan , Damla Kızıl , Rafet Eren , Elif Suyani

Öz

Background: Polypharmacy in hematological malignancies is also a research area with very little literature data. The development of personalized treatment approaches in this patient group is con-siderable for future needs. In our study, the aim was to investigate the effects of polypharmacy on treatment response, and survival in elderly patients with different hematological malignancies.
Method: The data of 91 patients, who were ≥ 60 years old, with the diagnosis of a hematological malignancy was analyzed retrospectively.
Results: The probability of overall survival at the end of the follow-up was 36% in patients receiv-ing ≤ 6 drugs, and 46% in patients receiving > 6 drugs (p=0.271). In subgroup analysis regarding the diagnosis of the patients, there was no difference between subgroups.
Conclusion: The polypharmacy is indispensable in a number of old patients with comorbidites, and this situation would not hinder the physicians from treating those patients with the diagnosis of he-matological maligancies, at least the indolent types.

Anahtar Kelimeler

Polypharmacy, treatment, response, survival, hematology

GERİATRİK HEMATOLOJİDE POLİFARMASİ DENEYİMİ

Öz

Amaç: Hematolojik malignitelerde polifarmasi, literatür verileri çok az olan bir araştırma alanıdır. Bu hasta grubunda kişiselleştirilmiş tedavi yaklaşımlarının geliştirilmesi gelecekteki ihtiyaçlar açısından dikkate değerdir. Çalışmamızda farklı hematolojik maligniteleri olan yaşlı hastalarda polifarmasinin tedaviye yanıt ve sağkalım üzerine etkilerinin araştırılması amaçlandı.
Yöntemler: Hematolojik malignite tanısı alan 60 yaş ve üzeri 91 hastanın verileri retrospektif olarak incelendi.
Bulgular: Takip sonunda genel sağkalım olasılığı ≤ 6 ilaç alan hastalarda %36, > 6 ilaç alan hastalarda %46 idi (p=0,271). Hastaların tanılarına ilişkin alt grup analizinde alt gruplar arasında fark yoktu.
Sonuç: Komorbiditesi olan birçok yaşlı hastada polifarmasi vazgeçilmezdir ve bu durum hekimlerin hematolojik malignite tanısı alan hastaları, en azından düşük dereceli tiplerini tedavi etmelerine engel olmayacaktır.

Anahtar Kelimeler

Polifarmasi, tedavi, yanıt, sağkalım, hematoloji

Kaynakça

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