KANSER GELİŞİMİNDE İNFLAMASYONUN ROLÜ

Yıl 2019, Cilt: 8 Sayı: 1, 121 - 140, 01.01.2019

İşıl Yıldırım

Öz

Karsinogenez hücre içsel ve hücre dışı süreçler, genom instabilitesi, proliferatif anormallik, yeniden programlama, stromal ortam ve anormal farklılaşma dâhil epitelyum ve mezenikmal haller arasında birden çok etkileşiminin sonucudur. İnflamasyonun dikkate değer bir özelliği, tümör oluşumu için gerekli çekirdek hücresel ve moleküler yeteneklerin çoğunu etkinleştirebilme yeteneğine sahiptir. İnflamasyonun neden olduğu kanserin başlıca mekanik prensiplerini anlamak, son araştırmalarda yapılan ilerlemeleri takip etmek önemli görüldüğünden kanser ile ilgili sürecin mevcudiyetine dayanarak geçmiş ve şuandaki durumunun tartışılması gerektiği açıkça görülmektedir. Bu amaçla, bu derlemede kanser oluşumu, gelişimi ve ilerlemesinde inflamasyonun rolü, kanser ve inflamasyon ile ilişkili yolaklar hakkında bilgi vermek hedeflenmiştir.

Anahtar Kelimeler

Kanser, İnflamasyon, İnflamasyon-Kanser yolakları, IL-, Cox, Tam, TGF-β

Kaynakça

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