Derleme
BibTex RIS Kaynak Göster
Yıl 2020, Cilt: 9 Sayı: 1, 146 - 154, 31.01.2020
https://doi.org/10.18036/estubtdc.515976

Öz

Kaynakça

  • Altındiş S, Adıgül MP. Mikrobiyota Çalışmalarında Etik, Sdü Sağlık Bilimleri Enstitüsü Dergisi, Cilt 8 Sayı 3, 2017.
  • Altuntaş Y, Batman A. Mikrobiyota ve metabolik sendrom, Turk Kardiyol Dern Ars 2017;45(3):286–296, 2017.
  • Aslan FG, Altındiş M. İnsan mikrobiyom projesi, mikrobiyotanın geleceği ve kişiye özel tıp uygulamaları. J Biotechnol and Strategic Health Res ;1 (Special issue):1-6,2017.
  • Azad MAK, Sarker M, Li T,Yin J. Probiotic Species in the Modulation of Gut Microbiota: An Overview. Hindawi BioMed Research International, Article ID 9478630, 8 p, 2018.
  • Berg G, Grube M, Schloter M, Smalla K. The plant microbiome and its importance for plant and human health. Front. Microbiol. 5, 491,2014.
  • Berg G, Mahnert A, Moissl-Eichinger C. Beneficial effects of plant-associatedmicrobes on indoor microbiomes and human health? Front. Microbiol. 5, 15.,2014.
  • Bilinski J, Grzesiowski P, Sorensen N, Madry K, Muszynski J, Robak K, et al., Fecal microbiota transplantation in patients with blood disorders inhibits gut colonization with antibiotic-resistant bacteria: results of a prospective, single-center study. Clin Infect Dis. doi:10.1093/cid/cix252, 2017.
  • Blaser MJ, Dominguez-Bello MG. The human microbiome before birth. Cell Host Microbe. 20, 558–560. doi: 10.1016/j.chom.20 16.10.014,2016.
  • Bommer C, et al., The global economic burden of diabetes in adults aged 20-79 years: a cost-of-illness study, Lancet Diabetes Endocrinol.5, 423, 2017
  • Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc 2013;78:240-9, 2013.
  • Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, et al. Council on Nutrition, P.A., Metabolism, Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121, 2331e2378, 2010.
  • Clemente JC., et al. , Sci. Adv. 1, e1500183,2015.
  • Dai L, Zanobetti A, Koutrakis P, Schwartz JD. Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis. Environ. Health Perspect. 122, 837e842.,2014.
  • De Filippo C, Cavalieri D,Di Paola M, Ramazzotti M, Poullet JB, Massart S, et al., , Impact of diet in shaping gut microbiota revealed by a comparative study in children fromEurope and rural Africa. Proc.Natl. Acad. Sci. U.S.A. 107, 14691–14696. doi: 10.1073/pnas.1005963107, 2010.
  • Dominguez Bello MG, Knight R, Gilbert JA, Blaser MJ, Science 362 (6410), 33-34, 2018.
  • Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal microbial flora. Science 308, 1635–1638. doi: 10.1126/science.1110591,2005.
  • Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, Faust K., et al.Population-level analysis of gut microbiome variation. Science 352, 560.doi: 10.1126/science.aad3503, 2016.
  • Graf D, Di Cagno R, Fak F, Flint HJ, Nyman M, Saarela M., Watzl B. “Contribution of diet to the composition of the human gut microbiota.” Microbial Ecology in Health and Disease 26:26164, 2015.
  • Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D. Outdoor particulate matter exposure and lung cancer: a systematic review and metaanalysis. Environ. Health Perspect. 122, 906e911.,2014.
  • Hawkins AK, O’Doherty KC. “Who owns your poop?” Insights regarding the intersection of human microbiome research and the ELSI aspects of biobanking and related studies. BMC Med Genomics 4:72, 2011.
  • Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, Chinwalla AT, et al. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214. doi: 10.1038/nature11234, 2012.
  • Johansson ML, Nobaek S, Berggren A, Nyman M, Björck I, Ahrne S, et al. Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats. International journal of food microbiology.;42(1):29-38, 1998.
  • Kaplan GG, Dixon E, Panaccione R, Fong A, Chen L. Szyszkowicz, M.,Wheeler, A., MacLean A, Buie WD, Leung T, Heitman SJ, Villeneuve PJ. Effect of ambient air pollution on the incidence of appendicitis. CMAJ (Can. Med. Assoc. J.) 181, 591e597,2009.
  • Kinkorová J. Biobanks in the era of personalized medicine: objectives, challenges, and innovation: overview. the EPMA Journal; 7(1): 4.,2016.
  • Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC. Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature;409:860–921, 2001.
  • Lopez-Abente G, Garcia-Perez J, Fernandez-Navarro P, Boldo E, Ramis R. Colorectal cancer mortality and industrial pollution in Spain. BMC Publ. Health, 12, 589.2012.
  • Lozupone CA Stombaugh JI Gordon JI et al. Diversity, stability and resilience of the human gut microbiota. Nature, 2012.
  • McFarland LV, Goh S. Preventing Pediatric Antibiotic Associated Diarrhea and Clostridium difficile infection with probiotics ; a meta-analysis. World J :meta-Analysis :1:102-120.,2013.
  • Mahnert A, Moissl-Eichinger C, Berg G. Microbiome interplay: plants alter microbial abundance and diversity within the built environment. Front. Microbiol. 6, 887.,2015.
  • Manrique P, Bolduc B, Walk ST, van der Oost J, de Vos WM, Young MJ. Healthy human gut phageome. Proc. Natl. Acad. Sci. U.S.A. 113, 10400–10405. doi: 10.1073/pnas.1601060113, 2016.
  • Martínez I, Stegen James C, Maldonado-Gómez Maria X, Eren AM, Siba, Peter M, Greenhill Andrew R, et al. The gut microbiota of rural papua new guineans: composition, diversity patterns, and ecological processes. Cell Rep. 11, 527–538. doi: 10.1016/j.celrep.2015.03.049, 2015.
  • Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, et al. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome, Environmental Pollution 240 (2018) 817e830.,2018.
  • Ou, J, Carbonero F, Zoetendal EG, DeLany JP, Wang M, Newton K, Gaskins HR, O’Keefe SJD. “Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African American.” The American Journal of Clinical Nutrition 98: 111–120, 2013.
  • Paulin L, Hansel N. Particulate Air Pollution and Impaired Lung Function. F1000Res 5, 2016.
  • Rao M, Gershon MD. The bowel and beyond: the enteric nervous system in neurological disorders.Nat Rev Gastroenterol Hepatol.;13(9):517-28, 2016.
  • Sahlberg B, Wieslander G, Norback D. Sick building syndrome in relation to domestic exposure in Sweden–a cohort study from1991 to 2001. Scand. J. Public Health 38, 232–238, 2010.
  • Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin in Gastroenterol ; 31(1): 69–75, 2015.Smits SA et al. Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania, Science 357, 802, 2017.
  • Şenol E, Antibiyotikler ve Mikrobiyota, Tüba-Mikrobiyota Ve İnsan Sağlığı Sempozyumu Raporu, 77-79, 2017.
  • Tannock G, Munro K, Harmsen H, Welling G, Smart J, Gopal P. Analysis of the fecal microfl ora of human subjects consuming a probiotic product containing Lactobacillus rhamnosusDR20. Applied and environmental microbiology. 2000;66(6):2578-88., 2000.
  • Tasnim N, Abulizi N, Pither J, Hart MM, Gibson DL. Linking the Gut Microbial Ecosystem with the Environment: Does Gut Health Depend on Where We Live? Frontiers in Microbiology, Volume 8, 2017.
  • Torrazza RM, Neu J.The developing intestinal microbiome and its relationship to health and disease in the neonate. J. Perinatol. 31, S29–S34. doi: 10.1038/jp.2010.172, 2011.
  • Tremaroli V, Backhed F. “Functional interactions between the gut microbiota and host metabolism.”Nature 489(7415):242-249, 2012.
  • Van de Wiele T, Vanhaecke L, Boeckaert C, Peru K, Headley J, Verstraete W, Siciliano S.,. Human colon microbiota transform polycyclic aromatic hydrocarbons to estrogenic metabolites. Environ Health Perspect; 113:6-10; PMID:15626640; http://dx.doi.org/10.1289/ehp.7259,2005.
  • Vincent R, Bjarnason SG, Adamson IY, Hedgecock C, Kumarathasan P, Guénette J, Potvin M, Goegan P, Bouthillier L. Acute pulmonary toxicity of urban particulate matter and ozone. Am J Pathol, 151:1563-70; PMID:9403707, 1997.
  • Xu Z, Knight R. Dietary effects on human gut microbiome diversity. Br J Nutr; 113: 1–5, 2015.Yatsunenko T et al.Human gut microbiome viewed across age and geography. Nature 486, 222.,2012.
  • Yıldırım S. Mikrobiyota-Beyin-Bağırsak Ekseni, Tüba-Mikrobiyota ve İnsan Sağlığı Sempozyumu Raporu, 94-95.2017.

İNSAN MİKROBİYOTASI

Yıl 2020, Cilt: 9 Sayı: 1, 146 - 154, 31.01.2020
https://doi.org/10.18036/estubtdc.515976

Öz

İnsan
mikrobiyotasının değişimi; beslenme, çevre, yaş, cinsiyet gibi birçok faktöre
bağlıdır. Son zamanlarda yapılan çalışmalarda, insan bağırsak sisteminde
bulunan bakterilerin astım, şeker hastalığı, obezite gibi hastalıkların sebebi
olduğu ortaya çıkmıştır. Sağlıklı mikrobiyota beslenme, çevre, yaş gibi
faktörlerin etkisiyle değişmektedir. Bu derlemede mikrobiyotanın değişimine
etki eden faktörler ve sağlıklı mikrobiyota korunumu hakkında yapılan
çalışmalar incelenmiştir.

Kaynakça

  • Altındiş S, Adıgül MP. Mikrobiyota Çalışmalarında Etik, Sdü Sağlık Bilimleri Enstitüsü Dergisi, Cilt 8 Sayı 3, 2017.
  • Altuntaş Y, Batman A. Mikrobiyota ve metabolik sendrom, Turk Kardiyol Dern Ars 2017;45(3):286–296, 2017.
  • Aslan FG, Altındiş M. İnsan mikrobiyom projesi, mikrobiyotanın geleceği ve kişiye özel tıp uygulamaları. J Biotechnol and Strategic Health Res ;1 (Special issue):1-6,2017.
  • Azad MAK, Sarker M, Li T,Yin J. Probiotic Species in the Modulation of Gut Microbiota: An Overview. Hindawi BioMed Research International, Article ID 9478630, 8 p, 2018.
  • Berg G, Grube M, Schloter M, Smalla K. The plant microbiome and its importance for plant and human health. Front. Microbiol. 5, 491,2014.
  • Berg G, Mahnert A, Moissl-Eichinger C. Beneficial effects of plant-associatedmicrobes on indoor microbiomes and human health? Front. Microbiol. 5, 15.,2014.
  • Bilinski J, Grzesiowski P, Sorensen N, Madry K, Muszynski J, Robak K, et al., Fecal microbiota transplantation in patients with blood disorders inhibits gut colonization with antibiotic-resistant bacteria: results of a prospective, single-center study. Clin Infect Dis. doi:10.1093/cid/cix252, 2017.
  • Blaser MJ, Dominguez-Bello MG. The human microbiome before birth. Cell Host Microbe. 20, 558–560. doi: 10.1016/j.chom.20 16.10.014,2016.
  • Bommer C, et al., The global economic burden of diabetes in adults aged 20-79 years: a cost-of-illness study, Lancet Diabetes Endocrinol.5, 423, 2017
  • Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc 2013;78:240-9, 2013.
  • Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, et al. Council on Nutrition, P.A., Metabolism, Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121, 2331e2378, 2010.
  • Clemente JC., et al. , Sci. Adv. 1, e1500183,2015.
  • Dai L, Zanobetti A, Koutrakis P, Schwartz JD. Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis. Environ. Health Perspect. 122, 837e842.,2014.
  • De Filippo C, Cavalieri D,Di Paola M, Ramazzotti M, Poullet JB, Massart S, et al., , Impact of diet in shaping gut microbiota revealed by a comparative study in children fromEurope and rural Africa. Proc.Natl. Acad. Sci. U.S.A. 107, 14691–14696. doi: 10.1073/pnas.1005963107, 2010.
  • Dominguez Bello MG, Knight R, Gilbert JA, Blaser MJ, Science 362 (6410), 33-34, 2018.
  • Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal microbial flora. Science 308, 1635–1638. doi: 10.1126/science.1110591,2005.
  • Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, Faust K., et al.Population-level analysis of gut microbiome variation. Science 352, 560.doi: 10.1126/science.aad3503, 2016.
  • Graf D, Di Cagno R, Fak F, Flint HJ, Nyman M, Saarela M., Watzl B. “Contribution of diet to the composition of the human gut microbiota.” Microbial Ecology in Health and Disease 26:26164, 2015.
  • Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D. Outdoor particulate matter exposure and lung cancer: a systematic review and metaanalysis. Environ. Health Perspect. 122, 906e911.,2014.
  • Hawkins AK, O’Doherty KC. “Who owns your poop?” Insights regarding the intersection of human microbiome research and the ELSI aspects of biobanking and related studies. BMC Med Genomics 4:72, 2011.
  • Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, Chinwalla AT, et al. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214. doi: 10.1038/nature11234, 2012.
  • Johansson ML, Nobaek S, Berggren A, Nyman M, Björck I, Ahrne S, et al. Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats. International journal of food microbiology.;42(1):29-38, 1998.
  • Kaplan GG, Dixon E, Panaccione R, Fong A, Chen L. Szyszkowicz, M.,Wheeler, A., MacLean A, Buie WD, Leung T, Heitman SJ, Villeneuve PJ. Effect of ambient air pollution on the incidence of appendicitis. CMAJ (Can. Med. Assoc. J.) 181, 591e597,2009.
  • Kinkorová J. Biobanks in the era of personalized medicine: objectives, challenges, and innovation: overview. the EPMA Journal; 7(1): 4.,2016.
  • Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC. Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature;409:860–921, 2001.
  • Lopez-Abente G, Garcia-Perez J, Fernandez-Navarro P, Boldo E, Ramis R. Colorectal cancer mortality and industrial pollution in Spain. BMC Publ. Health, 12, 589.2012.
  • Lozupone CA Stombaugh JI Gordon JI et al. Diversity, stability and resilience of the human gut microbiota. Nature, 2012.
  • McFarland LV, Goh S. Preventing Pediatric Antibiotic Associated Diarrhea and Clostridium difficile infection with probiotics ; a meta-analysis. World J :meta-Analysis :1:102-120.,2013.
  • Mahnert A, Moissl-Eichinger C, Berg G. Microbiome interplay: plants alter microbial abundance and diversity within the built environment. Front. Microbiol. 6, 887.,2015.
  • Manrique P, Bolduc B, Walk ST, van der Oost J, de Vos WM, Young MJ. Healthy human gut phageome. Proc. Natl. Acad. Sci. U.S.A. 113, 10400–10405. doi: 10.1073/pnas.1601060113, 2016.
  • Martínez I, Stegen James C, Maldonado-Gómez Maria X, Eren AM, Siba, Peter M, Greenhill Andrew R, et al. The gut microbiota of rural papua new guineans: composition, diversity patterns, and ecological processes. Cell Rep. 11, 527–538. doi: 10.1016/j.celrep.2015.03.049, 2015.
  • Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, et al. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome, Environmental Pollution 240 (2018) 817e830.,2018.
  • Ou, J, Carbonero F, Zoetendal EG, DeLany JP, Wang M, Newton K, Gaskins HR, O’Keefe SJD. “Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African American.” The American Journal of Clinical Nutrition 98: 111–120, 2013.
  • Paulin L, Hansel N. Particulate Air Pollution and Impaired Lung Function. F1000Res 5, 2016.
  • Rao M, Gershon MD. The bowel and beyond: the enteric nervous system in neurological disorders.Nat Rev Gastroenterol Hepatol.;13(9):517-28, 2016.
  • Sahlberg B, Wieslander G, Norback D. Sick building syndrome in relation to domestic exposure in Sweden–a cohort study from1991 to 2001. Scand. J. Public Health 38, 232–238, 2010.
  • Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin in Gastroenterol ; 31(1): 69–75, 2015.Smits SA et al. Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania, Science 357, 802, 2017.
  • Şenol E, Antibiyotikler ve Mikrobiyota, Tüba-Mikrobiyota Ve İnsan Sağlığı Sempozyumu Raporu, 77-79, 2017.
  • Tannock G, Munro K, Harmsen H, Welling G, Smart J, Gopal P. Analysis of the fecal microfl ora of human subjects consuming a probiotic product containing Lactobacillus rhamnosusDR20. Applied and environmental microbiology. 2000;66(6):2578-88., 2000.
  • Tasnim N, Abulizi N, Pither J, Hart MM, Gibson DL. Linking the Gut Microbial Ecosystem with the Environment: Does Gut Health Depend on Where We Live? Frontiers in Microbiology, Volume 8, 2017.
  • Torrazza RM, Neu J.The developing intestinal microbiome and its relationship to health and disease in the neonate. J. Perinatol. 31, S29–S34. doi: 10.1038/jp.2010.172, 2011.
  • Tremaroli V, Backhed F. “Functional interactions between the gut microbiota and host metabolism.”Nature 489(7415):242-249, 2012.
  • Van de Wiele T, Vanhaecke L, Boeckaert C, Peru K, Headley J, Verstraete W, Siciliano S.,. Human colon microbiota transform polycyclic aromatic hydrocarbons to estrogenic metabolites. Environ Health Perspect; 113:6-10; PMID:15626640; http://dx.doi.org/10.1289/ehp.7259,2005.
  • Vincent R, Bjarnason SG, Adamson IY, Hedgecock C, Kumarathasan P, Guénette J, Potvin M, Goegan P, Bouthillier L. Acute pulmonary toxicity of urban particulate matter and ozone. Am J Pathol, 151:1563-70; PMID:9403707, 1997.
  • Xu Z, Knight R. Dietary effects on human gut microbiome diversity. Br J Nutr; 113: 1–5, 2015.Yatsunenko T et al.Human gut microbiome viewed across age and geography. Nature 486, 222.,2012.
  • Yıldırım S. Mikrobiyota-Beyin-Bağırsak Ekseni, Tüba-Mikrobiyota ve İnsan Sağlığı Sempozyumu Raporu, 94-95.2017.
Toplam 46 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Yapısal Biyoloji
Bölüm Makaleler
Yazarlar

Didem Aksu 0000-0002-7184-4011

Basri Aksu Bu kişi benim 0000-0002-8983-4524

Yayımlanma Tarihi 31 Ocak 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 9 Sayı: 1

Kaynak Göster

APA Aksu, D., & Aksu, B. (2020). İNSAN MİKROBİYOTASI. Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, 9(1), 146-154. https://doi.org/10.18036/estubtdc.515976
AMA Aksu D, Aksu B. İNSAN MİKROBİYOTASI. Estuscience - Life. Ocak 2020;9(1):146-154. doi:10.18036/estubtdc.515976
Chicago Aksu, Didem, ve Basri Aksu. “İNSAN MİKROBİYOTASI”. Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 9, sy. 1 (Ocak 2020): 146-54. https://doi.org/10.18036/estubtdc.515976.
EndNote Aksu D, Aksu B (01 Ocak 2020) İNSAN MİKROBİYOTASI. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 9 1 146–154.
IEEE D. Aksu ve B. Aksu, “İNSAN MİKROBİYOTASI”, Estuscience - Life, c. 9, sy. 1, ss. 146–154, 2020, doi: 10.18036/estubtdc.515976.
ISNAD Aksu, Didem - Aksu, Basri. “İNSAN MİKROBİYOTASI”. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 9/1 (Ocak 2020), 146-154. https://doi.org/10.18036/estubtdc.515976.
JAMA Aksu D, Aksu B. İNSAN MİKROBİYOTASI. Estuscience - Life. 2020;9:146–154.
MLA Aksu, Didem ve Basri Aksu. “İNSAN MİKROBİYOTASI”. Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, c. 9, sy. 1, 2020, ss. 146-54, doi:10.18036/estubtdc.515976.
Vancouver Aksu D, Aksu B. İNSAN MİKROBİYOTASI. Estuscience - Life. 2020;9(1):146-54.

Cited By

Gut-Beyin Ekseni, Nörodejeneratif Hastalıklar Ve Mikrobiyatanın Etkileri
İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi
https://doi.org/10.47769/izufbed.1083687