Oksidatif stres ve selenyum arasındaki ilişki

Öz

Oksidatif stres, hücrelerdeki ve dokulardaki prooksidan moleküller ile bu reaktif molekülleri detoksifiye etmeye çalışan antioksidan moleküller arasındaki dengesizlik ile karakterize edilir. Oksidatif stres hem genetik hem de çevresel faktörlerden etkilenir. Selenyum esansiyel bir eser elementtir ve yetersizliği kanser ve kalp hastalığı gibi çeşitli hastalıklara yol açabilir. Selenyumun ana kaynağı besinlerdir ve genellikle deniz ürünleri, tahıllar, et ürünleri, süt, sebze ve meyvelerde bulunur. Selenyum antioksidan özelliklere sahip bir enzimdir ve seleno enzimlerinin yapısında yer alır. Bu yazıda selenyumun metabolizma ve antioksidan özellikleri gözden geçirilmiştir.

Anahtar Kelimeler

• oksidatif stres
• selenyum
• sağlık

The relationship between oxidative stress and selenium

Abstract

Oxidative stress is characterized by an imbalance between prooxidant molecules in cells and tissues and antioxidant molecules that try to detoxify these reactives molecules. Oxidative stress is affected by both genetic and environmental factors. Selenium is an essential trace element and inadequacy can lead to various types of diseases, such as cancer and heart disease. Foods are the main source of Selenium, and it is commonly found in seafood, grains, meat products, milk, vegetables and fruits. Selenium is an enzyme with antioxidant properties and is included in the structure of seleno enzymes. In this article, the metabolism and antioxidant properties of selenium are reviewed.

Keywords

• oxidative stress
• selenium
• health

Kaynakça

1. Gao J, Liu Y, Huang Y, et al. Daily selenium intake in a moderate selenium deficiency area of Suzhou, China. Food Chemistry. 2011 2011/06/01/;126(3):1088-1093.
2. Institute of Medicine Subcommittee on I, Uses of Dietary Reference I, Institute of Medicine Standing Committee on the Scientific Evaluation of Dietary Reference I. DRI Dietary Reference Intakes: Applications in Dietary Assessment. Washington (DC): National Academies Press (US)Copyright 2000 by the National Academy of Sciences. All rights reserved.; 2000.
3. Kang D, Lee J, Wu C, et al. The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies. Experimental & Molecular Medicine. 2020 08/13;52.
4. Tinggi U. Selenium: its role as antioxidant in human health. Environ Health Prev Med. 2008;13(2):102-108.
5. Zeng H, Combs GF, Jr. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. The Journal of nutritional biochemistry. 2008 Jan;19(1):1-7.
6. Barceloux DG, Barceloux D. Selenium. Journal of Toxicology: Clinical Toxicology. 1999 1999/01/01;37(2):145-172.
7. Saito Y. Selenium Transport Mechanism via Selenoprotein P—Its Physiological Role and Related Diseases [Mini Review]. 2021 2021-May-28;8.
8. Ferreira RLU, Sena-Evangelista KCM, de Azevedo EP, et al. Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases [Review]. 2021 2021-June-04;8.

9. Giray B, Hincal F. Oxidative DNA base damage, antioxidant enzyme activities and selenium status in highly iodine-deficient goitrous children. Free radical research. 2002 Jan;36(1):55-62.
10. Rayman MP. The importance of selenium to human health. Lancet (London, England). 2000 Jul 15;356(9225):233-41.
11. Brenneisen P, Steinbrenner H, Sies H. Selenium, oxidative stress, and health aspects. Molecular aspects of medicine. 2005 Aug-Oct;26(4-5):256-67.
12. Stapleton SR. Introduction: The selenium conundrum. Cellular and Molecular Life Sciences. 2000 Dec 2000;57(13):1823-1824.
13. Stawicki SP, Lyons M, Aloupis M, et al. Current evidence from phase III clinical trials of selenium supplementation in critically Ill patients: why should we bother? Mini reviews in medicinal chemistry. 2007 Jul;7(7):693-9.
14. Utomo A, Jiang X, Furuta S, et al. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. The Journal of biological chemistry. 2004 Oct 15;279(42):43522-9.
15. Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public health nutrition. 2001 Apr;4(2b):593-9.
16. Burton GJ, Jauniaux E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol. 2011;25(3):287-299.
17. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763-8416763.
18. Takeshima T, Usui K, Mori K, et al. Oxidative stress and male infertility [https://doi.org/10.1002/rmb2.12353]. Reproductive Medicine and Biology. 2021 2021/01/01;20(1):41-52.
19. Tan BL, Norhaizan ME, Liew W-P-P, et al. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Front Pharmacol. 2018;9:1162-1162.
20. Migdal C, Serres M. [Reactive oxygen species and oxidative stress]. Medecine sciences : M/S. 2011 Apr;27(4):405-12.
21. Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24(10):R453-R462.
22. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008;4(2):89-96.
23. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015;30(1):11-26.
24. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017 2017/07/27;2017:8416763.
25. Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772.
26. Zakeri N, kelishadi MR, Asbaghi O, et al. Selenium supplementation and oxidative stress: A review. PharmaNutrition. 2021 2021/09/01/;17:100263.
27. Akil M, Bicer M, Menevse E, et al. Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue. Bratislavske lekarske listy. 2011;112(6):314-7.
28. Ibrahim KS, Saleh ZA, Farrag AR, et al. Protective effects of zinc and selenium against benzene toxicity in rats. Toxicology and industrial health. 2011 Jul;27(6):537-45.
29. Savory LA, Kerr CJ, Whiting P, et al. Selenium supplementation and exercise: effect on oxidant stress in overweight adults. Obesity (Silver Spring, Md). 2012 Apr;20(4):794-801.