ECOSAR Modeli Kullanılarak Fosetyl-Alüminyum’un Hesaplamalı Ekotoksikolojik Risk Değerlendirmesi

Öz

Pestisit kullanımının artması, özellikle sucul ekosistemlerde ekolojik güvenlik endişelerini artırmıştır. Fosetyl-alüminyum (fosetyl-Al) sistemik bir fungisit olup hem fungal gelişimi baskılar hem de bitki savunma mekanizmalarını uyarır. Bu çalışmada, ECOSAR (Ekolojik Yapı–Aktivite İlişkisi) modeli kullanılarak fosetyl-Al’nin sucul ve karasal organizmalar üzerindeki akut ve kronik toksisitesi öngörülmüştür. Sonuçlar, “doygunlukta etki yok” bulgusunu sürekli olarak göstermiş ve gerçekçi maruziyet koşullarında düşük akut risk ortaya koymuştur. Deneysel verilerle de doğrulanan bu bulgular, fosetyl-Al’nin çevresel açıdan düşük riskli bir fungisit olduğunu ve ekotoksikolojik ön değerlendirmelerde hesaplamalı QSAR yaklaşımlarının önemini ortaya koymaktadır.

Anahtar Kelimeler

• fosetly-alüminyum
• ecosar
• qsar
• sucuk toksisite
• çevresel risk

In Silico Ecotoxicological Risk Assessment of Fosetyl-Aluminium Using the ECOSAR Model

Öz

The increasing use of pesticides has raised global concerns about their ecological safety, especially in aquatic systems. Fosetyl-aluminium (fosetyl-Al), a systemic fungicide, acts by inhibiting fungal growth and stimulating plant defense. In this study, the Ecological Structure–Activity Relationship (ECOSAR) model was applied to predict its acute and chronic toxicity towards aquatic and terrestrial organisms. Results consistently indicated “no effects at saturation,” suggesting minimal acute risk under realistic exposure. These findings, corroborated by experimental data, highlight fosetyl-Al as an environmentally low-risk fungicide and demonstrate the value of QSAR-based in silico approaches in preliminary ecological risk assessment.

Anahtar Kelimeler

• fosetly-aluminium
• ecosar
• qsar
• aquatic toxicity
• envorimental risk

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