BibTex RIS Kaynak Göster

Mısır’da bir koyun çiftliğinde ovine pulmoner adenokarsinoma

Yıl 2014, Cilt: 30 Sayı: 1, 39 - 43, 01.03.2014

Öz

Ovine pulmonar adenokarsinoma koyunlarda retrovirüsün
neden olduğu akciğer kanseridir. Mevcut vaka raporunun
amacı Mısır’da bir koyun çiftliğinde hastalığın histopatalojik
ve klinik tanımı yapmaktır. Çiftlikteki 4 adeti ölü ve 5 adeti
hasta genç koyuna klinik, makroskobik ve histopatalojik de-
ğerlendirmeler yapıldı. Histopatalojik incelemeler için akci-
ğer, mediastinal lenf yumruları, karaciğer, kalp, böbrek ve beyin
dokusu örnekleri alındı. Örnekler %10 formalde tespit
edildi ve ışık mikroskopta incelendi. İncelene hayvanlarda
ağır kilo kaybı ve burunda mokuid akıntı gözlendi. Nekropside
akciğer çok sayıda grimsi köpüklü sıvı ve pleural boşluk
mukois sıvı birikimi gözlendi. Histopatalojik incelemede çok
sayıda alveolar epitek kökenli kapsülsüz neoplastik odaklar
tespit edildi. Neoplastik odak kübik ve sütun hücrelerden
oluşmaktaydı. Bunlar düzenli papillar ve asiner şekilde belirlendi.
Proliferatif hücreler küçük damar hücreleri ve fibroblast
içeren yumuşak doku ile desteklenmiş olarak belirlendi.
Neoplastic odaklarla ilişkili alveolar boşluklarda çok sayıda
şişkin makrofaj varlığı belirgindi. Sonuç olarak ovine pulmonar
adenokarsinomalar için kübik ve uzun hücrelerle kaplı
alveolar epitelin transformasyonu ve burundan mukoid sıvı
akıntısı patognomiktir.

Kaynakça

  • Bancroft JD, Stevens A, 1990. Theory and Practice of Histological Technique, third edition, Churchill Livingstone, Edinburgh, Scotland, UK.
  • Cousens C, Thonur L, Imlach S, Crawford J, Sales J, Griffiths DJ, 2009. Jaagsiekte sheep retrovirus is present at high concentration in lung fluid produced by ovine pulmonary adenocarcinoma-affected sheep and can survive for several weeks at ambient temperatures. Res Vet Sci, 87, 154- 156.
  • De las Heras M, González L, Sharp JM, 2003. Pathology of ovine pulmonary adenocarcinoma. Curr Top Microbiol Immunol, 275, 25-54.
  • Fan H, Palmarini M, DeMartini JC, 2009. Transformation and oncogenesis by jaagsiekte sheep retrovirus. Curr Top Microbiol Immunol, 275, 139-177.
  • Grego E, De Meneghi D, Alvarez V, Benito AA, Minguijon E, Ortin A, Mattoni M, Moreno B, Perez de Villarreal M, Alberti A, Capucchio MT, Caporale M, Juste R, Rosati S, De las Heras M, 2008. Colostrum and milk can transmit jaagsiekte retrovirus to lambs. Vet Microbiol, 130, 247-257.
  • Griffiths DJ, Martineau HM, Cousens C, 2010. Pathology and pathogenesis of ovine pulmonary adenocarcinoma. J Comp Pathol, 142, 260-283.
  • Kycko A, Reichert M, 2007. Current views on the mechanism of oncogenic cell transformation in ovine pulmonary adenocarcinoma. Postepy Hig Med Dosw, 61, 797-804.
  • Leroux C, Girard N, Cottin V, Greenland T, Mornex JF, Archer F, 2007. Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep. Vet Res, 38, 211-228.
  • Maeda N, Inoshima Y, Oouchi S, Uede T, 2011. Surveillance of Jaagsiekte sheep retrovirus in sheep in Hokkaido, the northern island of Japan. J Vet Med Sci, 73, 1493-1495.
  • Minguijon E, Gonzalez L, De Las Heras M, Gomez N, GarciaGoti M, Juste RA, Moreno B, 2013. Pathological and aetiological studies in sheep exhibiting extrathoracic metastasis of Ovine Pulmonary Adenocarcinoma (Jaagsiekte). J Comp Pathol, 148, 139-147.
  • Murgia C, Caporale M, Ceesay O, Di Francesco G, Ferri N, Varasano V, de las Heras M, Palmarini M, 2011. Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair. PLoS Pathog [Epub 2011]. doi: 10.1371/journal.ppat.1002014
  • Oda SS, Youssef SA, 2011. Immunohistochemical and histopathological findings of ovine pulmonary adenocarcinoma (Jaagsiekte) in Egyptian sheep. Trop Anim Health Prod, 43, 1611-1615.
  • Palmarini M, Fan H, 2001. Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer. J Natl Cancer Inst, 93, 1603-1614.
  • Summers C, Norval M, De Las Heras M, Gonzalez L, Sharp JM, Woods GM, 2005. An influx of macrophages is the predominant local immune response in ovine pulmonary adenocarcinoma. Vet Immunol Immunopathol, 106, 285-294.
  • Wootton SK, Metzger MJ, Hudkins KL, Alpers CE, York D, DeMartini JC, Miller AD, 2006. Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. Retrovirology, 3, 94-108.
  • York DF, Querat G, 2003. A history of ovine pulmonary adenocarcinoma (jaagsiekte) and experiments leading to the deduction of the JSRV nucleotide sequence. Curr Top Microbiol Immunol, 275, 1-23.

Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm

Yıl 2014, Cilt: 30 Sayı: 1, 39 - 43, 01.03.2014

Öz

Ovine pulmonary adenocarcinoma is a naturally occurring
retrovirus-induced contagious lung neoplasm in sheep. The
current report aims to describe clinical and histopathological
characteristics of the disease in an Egyptian sheep farm.
In which, 4 dead and 5 sick young sheep were subjected to
clinical, gross and histopathological examinations. For histopathological
examination, tissue specimens were taken
from lungs, mediastinal lymph nodes, liver, heart, kidneys
and brain, fixed in 10% neutral buffered formalin and processed
for light microscopy. Examined animals showed release
of copious amount of mucoid fluid from their nostrils
and marked loss of body weight. At necropsy, there were
many solid grayish nodules exuding frothy fluid in the lungs
and accumulation of mucoid fluid in the pleural cavity. Histopathological
examination revealed presence of many nonencapsulated
neoplastic foci originating from the alveolar
epithelial lining. Neoplastic foci consisted of cuboidal and
columnar cells that arranged in papillary and acinar forms.
Proliferating cells appeared supported by loose connective
tissue containing some fibroblasts and small blood vessels.
Prominently, there was large number of swollen and ruffled
macrophages in alveolar spaces adjacent to neoplastic foci.
In conclusions, release of copious amount of mucoid fluid
from nostrils and transformation of alveolar epithelial lining
into cuboidal and columnar cells are pathognomonic for
ovine pulmonary adenocarcinoma.

Kaynakça

  • Bancroft JD, Stevens A, 1990. Theory and Practice of Histological Technique, third edition, Churchill Livingstone, Edinburgh, Scotland, UK.
  • Cousens C, Thonur L, Imlach S, Crawford J, Sales J, Griffiths DJ, 2009. Jaagsiekte sheep retrovirus is present at high concentration in lung fluid produced by ovine pulmonary adenocarcinoma-affected sheep and can survive for several weeks at ambient temperatures. Res Vet Sci, 87, 154- 156.
  • De las Heras M, González L, Sharp JM, 2003. Pathology of ovine pulmonary adenocarcinoma. Curr Top Microbiol Immunol, 275, 25-54.
  • Fan H, Palmarini M, DeMartini JC, 2009. Transformation and oncogenesis by jaagsiekte sheep retrovirus. Curr Top Microbiol Immunol, 275, 139-177.
  • Grego E, De Meneghi D, Alvarez V, Benito AA, Minguijon E, Ortin A, Mattoni M, Moreno B, Perez de Villarreal M, Alberti A, Capucchio MT, Caporale M, Juste R, Rosati S, De las Heras M, 2008. Colostrum and milk can transmit jaagsiekte retrovirus to lambs. Vet Microbiol, 130, 247-257.
  • Griffiths DJ, Martineau HM, Cousens C, 2010. Pathology and pathogenesis of ovine pulmonary adenocarcinoma. J Comp Pathol, 142, 260-283.
  • Kycko A, Reichert M, 2007. Current views on the mechanism of oncogenic cell transformation in ovine pulmonary adenocarcinoma. Postepy Hig Med Dosw, 61, 797-804.
  • Leroux C, Girard N, Cottin V, Greenland T, Mornex JF, Archer F, 2007. Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep. Vet Res, 38, 211-228.
  • Maeda N, Inoshima Y, Oouchi S, Uede T, 2011. Surveillance of Jaagsiekte sheep retrovirus in sheep in Hokkaido, the northern island of Japan. J Vet Med Sci, 73, 1493-1495.
  • Minguijon E, Gonzalez L, De Las Heras M, Gomez N, GarciaGoti M, Juste RA, Moreno B, 2013. Pathological and aetiological studies in sheep exhibiting extrathoracic metastasis of Ovine Pulmonary Adenocarcinoma (Jaagsiekte). J Comp Pathol, 148, 139-147.
  • Murgia C, Caporale M, Ceesay O, Di Francesco G, Ferri N, Varasano V, de las Heras M, Palmarini M, 2011. Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair. PLoS Pathog [Epub 2011]. doi: 10.1371/journal.ppat.1002014
  • Oda SS, Youssef SA, 2011. Immunohistochemical and histopathological findings of ovine pulmonary adenocarcinoma (Jaagsiekte) in Egyptian sheep. Trop Anim Health Prod, 43, 1611-1615.
  • Palmarini M, Fan H, 2001. Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer. J Natl Cancer Inst, 93, 1603-1614.
  • Summers C, Norval M, De Las Heras M, Gonzalez L, Sharp JM, Woods GM, 2005. An influx of macrophages is the predominant local immune response in ovine pulmonary adenocarcinoma. Vet Immunol Immunopathol, 106, 285-294.
  • Wootton SK, Metzger MJ, Hudkins KL, Alpers CE, York D, DeMartini JC, Miller AD, 2006. Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. Retrovirology, 3, 94-108.
  • York DF, Querat G, 2003. A history of ovine pulmonary adenocarcinoma (jaagsiekte) and experiments leading to the deduction of the JSRV nucleotide sequence. Curr Top Microbiol Immunol, 275, 1-23.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA64PR55MU
Bölüm Olgu Sunumu
Yazarlar

Khaled Radad Bu kişi benim

Sary Khalil Bu kişi benim

Yayımlanma Tarihi 1 Mart 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 30 Sayı: 1

Kaynak Göster

APA Radad, K., & Khalil, S. (2014). Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm. Eurasian Journal of Veterinary Sciences, 30(1), 39-43.
AMA Radad K, Khalil S. Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm. Eurasian J Vet Sci. Mart 2014;30(1):39-43.
Chicago Radad, Khaled, ve Sary Khalil. “Natural Ovine Pulmonary Adenocarcinoma in an Egyptian Sheep Farm”. Eurasian Journal of Veterinary Sciences 30, sy. 1 (Mart 2014): 39-43.
EndNote Radad K, Khalil S (01 Mart 2014) Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm. Eurasian Journal of Veterinary Sciences 30 1 39–43.
IEEE K. Radad ve S. Khalil, “Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm”, Eurasian J Vet Sci, c. 30, sy. 1, ss. 39–43, 2014.
ISNAD Radad, Khaled - Khalil, Sary. “Natural Ovine Pulmonary Adenocarcinoma in an Egyptian Sheep Farm”. Eurasian Journal of Veterinary Sciences 30/1 (Mart 2014), 39-43.
JAMA Radad K, Khalil S. Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm. Eurasian J Vet Sci. 2014;30:39–43.
MLA Radad, Khaled ve Sary Khalil. “Natural Ovine Pulmonary Adenocarcinoma in an Egyptian Sheep Farm”. Eurasian Journal of Veterinary Sciences, c. 30, sy. 1, 2014, ss. 39-43.
Vancouver Radad K, Khalil S. Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm. Eurasian J Vet Sci. 2014;30(1):39-43.