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İnek somatotropini uygulaması veya omega-3 zengini balık yağı (FO) ile beslenen ineklerde peroxisome proliferator-activated reseptörlerinin (PPAR) ekspresyonunu etkiler

Yıl 2011, Cilt: 27 Sayı: 4, 207 - 218, 01.12.2011

Öz

Amaç: Çalışmanın amaçları, holştayn ırkı ineklerin rasyonuna 90 gün boyunca zenginleştirilmiş balık yağı formunda uzun zincirli omega-3 çoklu doymamış balık yağı katılmasının veya ovulasyon günü ve 11 gün sonrasında iki kere inek somatotropin enjeksiyonunun endometriumunda PPAR ekspresyonu ve aktivasyonunu araştırmaktır. Gereç ve Yöntem: Laktasyonda olmayan inekler siklik, siklik-bST, gebe veya gebe-bST olmak üzere 4 gruba ayrıldı. Laktasyondaki inekler ise siklik, siklik-bST, gebe, gebe-bST, siklik-FO veya siklik-FO-bST olmak üzere 6 gruba ayrıldı.Bulgular: Northern ve Western blot analizleri PPARα ve PPARδ’nın ovulasyon sonrası 17. günde endometriumda ekspre edildiğini belirlendi ancak PPARγ tespit edilemedi. bST uygulaması sadece gebelerde PPARδ mRNA ekspresyonunu arttırdı, bu etki embriyo tarafından düzenlenmiş olabilir. Laktasyondaki gebe ineklerin endometriumundaki bST’ya bağlı PPARα mRNA miktarındaki artış bST etkisinin gebelik durumuna bağlı olduğunu vurgulamaktadır. Rasyona balık yağı eklenmesi PPARδ mRNA miktarını azaltırken, PPARα mRNA miktarı üzerine bir etkisi olmadı. PPARδ proteini luminal epitelde, glandular epitelde, subepitel stromada ve az miktarda da adluminal stromada belirlendi. Anti-PPARδ reaksiyonu bST uygulaması ve balık yağı beslemesine bağlı olarak gebe ineklerde azaldı. Öneri: bST uygulaması ve balık yağı beslemesi endometrial
PPARα ve PPARδ ekspresyonun laktasyondaki sütçü ineklerde etkilemektedir.

Kaynakça

  • Arosh JA, Banu SK, Chapdelaine P, Emond V, Kim JJ, MacLar- en LA, Fortier MA, 2003. Molecular cloning and charac- terization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early preg- nancy. Endocrinology, 144, 3076-3091.
  • Bilby TR, Guzeloglu A, Kamimura S, Pancarci SM, Michel F, Head HH, Thatcher WW, 2004. Pregnancy and bovine somatotropin in nonlactating dairy cows: I. Ovarian, conceptus and insulin-like growth factor system re- sponses. J Dairy Sci, 87, 3256-3267.
  • Bilby TR, Guzeloglu A, MacLaren LA, Staples CR, Thatcher WW, 2006c. Pregnancy, bovine somatotropin, and di- etary n-3 fatty acids in lactating dairy cows: II. Endo- metrial gene expression related to maintenance of preg- nancy. J Dairy Sci, 89, 3375-3385.
  • Bilby TR, Jenkins T, Staples CR, Thatcher WW, 2006a. Preg- nancy, bovine somatotropin, and dietary n-3 Fatty ac- ids in lactating dairy cows: III. Fatty acid distribution. J Dairy Sci, 89, 3386-3399.
  • Bilby TR, Sozzi A, Lopez MM, Silvestre F, Ealy AD, Staples CR, Thatcher WW, 2006b. Pregnancy, bovine somatotro- pin, and dietary n-3 fatty acids in lactating dairy cows: I. Ovarian, conceptus and growth hormone-insulin-like growth factor system responses. J Dairy Sci, 89, 1-15.
  • Burdick AD, Kim DJ, Peraza MA, Gonzalez FJ, Peters JM, 2006. The role of peroxisome proliferator-activated re- ceptor beta/delta in epithelial cell growth and differen- tiation. Cell Signal, 18, 9-20.
  • Burke JM, Staples CR, Risco CA, De la Sota RL, Thatcher WW, 1997. Effect of ruminant grade menhaden fish meal on reproductive and productive performance of lactating dairy cows. J Dairy Sci, 80, 3386-3398.
  • Cammas L, Reinaud P, Bordas N, Dubois O, Germain G, Charpigny G, 2006. Developmental regulation of prosta- cyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation pe- riod. Reproduction, 131, 917-927.
  • Carlsson L, Linden D, Jalouli M, Oscarsson J, 2001. Effects of fatty acids and growth hormone on liver fatty acid bind- ing protein and PPARα in rat liver. Am J Physiol Endocri- nol Metab, 281, 772-781.
  • Cernuda-Morollon E, Rodriguez-Pascual F, Klatt P, Lamas S, Perez-Sala D, 2002. PPAR agonists amplify iNOS expres- sion while inhibiting NF-kappaB: implications for me- sangial cell activation by cytokines. J Am Soc Nephrol, 13, 2223-2231.
  • Chambrier C, Bastard JP, Rieusset J, Chevillotte E, Bonnefont- Rousselot D, Therond P, Hainque B, Riou JP, Laville M, Vidal H, 2002. Eicosapentaenoic acid induces mRNA ex- pression of peroxisome proliferator-activated receptor γ. Obes Res, 10, 518-525.
  • Chegini N, Rao CV, 1989. The presence of prostacyclin bind- ing sites in nonpregnant bovine uterine tissue. Prosta- glandins Leukot Essent Fatty Acids, 38, 75-79.
  • Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner K, Hennighausen L, 2002. Loss of the peroxi- some proliferation-activated receptor gamma (PPARγ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem, 277, 17830-17835.
  • D’Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Green- berg AS, 2005. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic reg- ulation of lipogenic and oxidative pathways. J Biol Chem, 280, 35983-35991.
  • Desmarais J, Bennett RD, Gevry N, Murphy BD, 2002. The role of peroxisome proliferator-activated receptor δ (PPARδ) in the process of implantation in the mink (Mustela vison). Biol Reprod, 67 (Suppl.1), 63 (abst).
  • Desvergne B, Wahli W, 1999. Control of metabolism by PPARs. Endocr Rev, 20, 649-688.
  • Ding NZ, Ma XH, Diao HL, Xu LB, Yang ZM, 2003a. Differen- tial expression of peroxisome proliferator-activated re- ceptor delta at implantation sites and in decidual cells of rat uterus. Reproduction, 125, 817-825.
  • Ding NZ, Teng CB, Ma H, Ni H, Ma XH, Xu LB, Yang ZM, 2003b. Peroxisome proliferator-activated receptor delta ex- pression and regulation in mouse uterus during embryo implantation and decidualization. Mol Reprod Dev, 66, 218-224.
  • Emond V, MacLaren LA, Kimmins S, Arosh JA, Fortier MA, Lambert RD, 2004. Expression of cyclooxygenase-2 and granulocyte-macrophage colony-stimulating factor in the endometrial epithelium of the cow is up-regulated during early pregnancy and in response to intrauterine infusions of interferon-tau. Biol Reprod, 70, 54-64.
  • Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B, 2001. Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology, 142, 4195-4202.
  • Faddy HM, Robinson JA, Lee WJ, Holman NA, Monteith GR, Roberts-Thomson SJ, 2006. Peroxisome proliferator- activated receptor α expression is regulated by estrogen receptor α and modulates the response of MCF-7 cells to sodium butyrate. Int J Biochem Cell Biol, 38, 255-266.
  • Fauti T, Uller-Brusselbach S, Kerutzer M, Rieck M, Meissner W, RappU, Schweer H, Komhoff M, Muller R, 2006. In- duction of PPARbeta and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARbeta. FEBS J, 273, 669-671.
  • Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W, 2006. From molecular action to physiological outputs: peroxi- some proliferator-activated receptors are nuclear re- ceptors at the crossroads of key cellular functions. Prog Lipid Res, 45, 120-59.
  • Fournier T, Tsatsaris V, Handschuh K, Evain-Brion D, 2007. PPARs and the placenta. Placenta, 28, 65-76.
  • Guzeloglu A, Bilby TR, Meikle A, Kamimura S, Kowalski A, Michel F, MacLaren LA, Thatcher WW, 2004. Pregnancy and bovine somatotropin in nonlactating dairy cows: II. Endometrial gene expression related to maintenance of pregnancy. J Dairy Sci, 87, 3268-3279.
  • Han S, Ritzenthaler JD, Wingerd B, Roman J, 2005. Activa- tion of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer- binding protein beta. J Biol Chem, 280, 33240-33249.
  • He TC, Chan TA, Vogelstein B, Kinzler KW, 1999. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, 99, 335-345.
  • Kalajdzic T, Faour WH, He QW, Fahmi H, Martel-Pelletier J, Pelletier JP, Di Battista JA, 2002. Nimesulide, a preferen- tial cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxy- genase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. Arthritis Rheum, 46, 494-506.
  • Krey G, Braissant O, L’Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W, 1997. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxi- some proliferator-activated receptors by coactivator- dependent receptor ligand assay. Mol Endocrinol, 11, 779-791.
  • Larsen LK, Amri EZ, Mandrup S, Pacot C, Kristiansen K, 2002. Genomic organization of the mouse peroxisome proliferator-activated receptor β/δ gene: alternative promoter usage and splicing yield transcripts exhibit- ing differential translational efficiency. J Biochem, 366, 767-775.
  • Lee JY, Hwang DH, 2002. Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated recep- tors in a colon tumor cell line. Biochem Biophys Res Commun, 298, 667-674.
  • Lim H, Gupta RA, Ma W, Paria BC, Moller DE, Morrow JD, Du- Bois RN, Trzaskos JM, Dey SK, 1999. Cyclo-oxygenase-2- deprived prostacyclin mediates embryo implantation in the mouse via PPARδ. Gene Dev, 13, 1561-1574.
  • Liu SF, Haddad E, Adcock I, Salmon M, Koto H, Gilbey T, 1995. Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rats. Amer J Physiol, 37, 331-338.
  • Lord E, Murphy BD, Desmarais JA, Ledoux S, Beaudry D, Pal- in MF, 2006. Modulation of peroxisome proliferator-ac- tivated receptor delta and gamma transcripts in swine endometrial tissue during early gestation. Reproduc- tion, 131, 929-942.
  • MacLaren LA, Guzeloglu A, Michel F, Thatcher WW, 2006. Peroxisome proliferator-activated receptor (PPAR) expression in cultured bovine endometrial cells and response to omega-3 fatty acid, growth hormone and agonist stimulation in relation to series 2 prostaglandin production. Domest Anim Endocrinol, 30, 155-169.
  • Mattos R, Staples CR, Williams J, Amorocho A, McGuire MA, Thatcher WW, 2002. Uterine, ovarian and production responses of lactating dairy cows to increasing dietary concentrations of menhaden fish meal. J Dairy Sci, 85, 755-764.
  • Meade EA, McIntyre TM, Zimmerman GA, Prescott SM, 1999. Peroxisome proliferators enhance cyclooxygenase-2 ex- pression in epithelial cells. J Biol Chem, 274, 8328-8334.
  • Moreira F, Badinga L, Burnley C, Thatcher WW, 2002. Bo- vine somatotropin increases embryonic development in superovulated cows and improves post-transfer preg- nancy rates when given to lactating recipient cows. The- riogenology, 57, 1371-1387.
  • Nunez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH, 1998. Retinoid X receptor and peroxisome proliferator-activated receptor activated an estrogen responsive gene independent of the estrogen receptor. Mol Cell Endocrinol, 127, 27-40.
  • Perez MA, Hansen RA, Harris MA, Allen KG, 2006. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase pro- duction. J Nutr Biochem, 17, 446-453.
  • Santos JE, Juchem SO, Cerri RL, Galvao KN, Chebel RC, Thatcher WW, Dei CS, Bilby CR, 2004. Effect of bST and reproductive management on reproductive perfor- mance of Holstein dairy cows. J Dairy Sci, 87, 868-881.
  • Sethi S, Ziouzenkova O, Heyu N, Wagner DD, Plutzky J, Maya- das TN, 2002. Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through acti- vation of PPARα. Blood, 100, 1340-1346.
  • Silvestre FT, Carvalho TSM, Francisco N, Santos JEP, Staples CR, Jenkins TC, Thatcher WW, 2011. Effects of differen- tial supplementation of fatty acids during the peripar- tum and breeding periods of Holstein cows: I. Uterine and metabolic responses, reproduction and lactation. J Dairy Sci, 94, 189-204.
  • Sundvold H, Brzozowska A, Lien S, 1997. Characterisation of bovine peroxisome proliferator-activated receptors gamma 1 and gamma 2: genetic mapping and differen- tial expression of the two isoforms.Biochem Biophys Res Commun, 239, 857-861.
  • Thatcher WW, Bilby TR, Bartolome JA, Silvestre F, Staples CR, Santos JEP, 2006. Strategies for improving fertility in the modern dairy cow. Theriogenology, 65, 30-44.
  • Wamsley NE, Burns PD, Engle TE, Enns RM, 2005. Fish meal supplementation alters uterine prostaglandin F2alpha synthesis in beef heifers with low luteal-phase proges- terone. J Anim Sci, 83, 1832-1838.
  • Zhou YC, Waxman DJ, 1999. Cross-talk between janus ki- nase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated re- ceptor α (PPARα) signaling pathways. J Biol Chem, 274, 2672-2681.

Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors

Yıl 2011, Cilt: 27 Sayı: 4, 207 - 218, 01.12.2011

Öz

Aim: The study objectives were to determine whether dietary supplementation with long chain omega-3 polyunsaturated fatty acids in the form of enriched fish oil (FO) for 90 days or treatment with bovine somatotropin (bST) at the time of ovulation and 11 days post-ovulation influenced PPAR expression and activation in bovine endometrium in Holstein cows.Materials and Methods: Non-lactating cows were assigned to one of four treatments: cyclic, cyclic-bST, pregnant or pregnant-bST. Lactating cows were assigned to one of six treatments: cyclic, cyclic-bST, pregnant, pregnant-bST, cyclic-FO or cyclic-FO-bST.Results: Northern and Western blot analyses indicated that PPARα and PPARδ, but not PPARγ, are expressed in endometrium from all cows at day 17 post-ovulation. Treatment with bST is associated with increased PPARδ mRNA abundance in pregnant but not cyclic cows, suggesting that the effect may be mediated by the embryo. Increased abundances of PPARα mRNA are observed in response to bST during pregnancy in lactating cows but not in non-lactating cows, highlighting the importance of lactation status in determining bST response. Fish oil supplementation is associated with reduced PPARδ mRNA abundance, but did not affect steady-state PPARα mRNA abundance. PPARδ protein is expressed in the luminal epithelium, glandular epithelium, subepithelial stroma and to a lesser extent in the adluminal stroma. Anti-PPARδ reactivity is reduced in response to bST and fish oil treatments in pregnant cows.Conclusion: bST and fish oil treatments affect endometrial PPARα and PPARδ expression in lactating dairy cows.

Kaynakça

  • Arosh JA, Banu SK, Chapdelaine P, Emond V, Kim JJ, MacLar- en LA, Fortier MA, 2003. Molecular cloning and charac- terization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early preg- nancy. Endocrinology, 144, 3076-3091.
  • Bilby TR, Guzeloglu A, Kamimura S, Pancarci SM, Michel F, Head HH, Thatcher WW, 2004. Pregnancy and bovine somatotropin in nonlactating dairy cows: I. Ovarian, conceptus and insulin-like growth factor system re- sponses. J Dairy Sci, 87, 3256-3267.
  • Bilby TR, Guzeloglu A, MacLaren LA, Staples CR, Thatcher WW, 2006c. Pregnancy, bovine somatotropin, and di- etary n-3 fatty acids in lactating dairy cows: II. Endo- metrial gene expression related to maintenance of preg- nancy. J Dairy Sci, 89, 3375-3385.
  • Bilby TR, Jenkins T, Staples CR, Thatcher WW, 2006a. Preg- nancy, bovine somatotropin, and dietary n-3 Fatty ac- ids in lactating dairy cows: III. Fatty acid distribution. J Dairy Sci, 89, 3386-3399.
  • Bilby TR, Sozzi A, Lopez MM, Silvestre F, Ealy AD, Staples CR, Thatcher WW, 2006b. Pregnancy, bovine somatotro- pin, and dietary n-3 fatty acids in lactating dairy cows: I. Ovarian, conceptus and growth hormone-insulin-like growth factor system responses. J Dairy Sci, 89, 1-15.
  • Burdick AD, Kim DJ, Peraza MA, Gonzalez FJ, Peters JM, 2006. The role of peroxisome proliferator-activated re- ceptor beta/delta in epithelial cell growth and differen- tiation. Cell Signal, 18, 9-20.
  • Burke JM, Staples CR, Risco CA, De la Sota RL, Thatcher WW, 1997. Effect of ruminant grade menhaden fish meal on reproductive and productive performance of lactating dairy cows. J Dairy Sci, 80, 3386-3398.
  • Cammas L, Reinaud P, Bordas N, Dubois O, Germain G, Charpigny G, 2006. Developmental regulation of prosta- cyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation pe- riod. Reproduction, 131, 917-927.
  • Carlsson L, Linden D, Jalouli M, Oscarsson J, 2001. Effects of fatty acids and growth hormone on liver fatty acid bind- ing protein and PPARα in rat liver. Am J Physiol Endocri- nol Metab, 281, 772-781.
  • Cernuda-Morollon E, Rodriguez-Pascual F, Klatt P, Lamas S, Perez-Sala D, 2002. PPAR agonists amplify iNOS expres- sion while inhibiting NF-kappaB: implications for me- sangial cell activation by cytokines. J Am Soc Nephrol, 13, 2223-2231.
  • Chambrier C, Bastard JP, Rieusset J, Chevillotte E, Bonnefont- Rousselot D, Therond P, Hainque B, Riou JP, Laville M, Vidal H, 2002. Eicosapentaenoic acid induces mRNA ex- pression of peroxisome proliferator-activated receptor γ. Obes Res, 10, 518-525.
  • Chegini N, Rao CV, 1989. The presence of prostacyclin bind- ing sites in nonpregnant bovine uterine tissue. Prosta- glandins Leukot Essent Fatty Acids, 38, 75-79.
  • Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner K, Hennighausen L, 2002. Loss of the peroxi- some proliferation-activated receptor gamma (PPARγ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem, 277, 17830-17835.
  • D’Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Green- berg AS, 2005. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic reg- ulation of lipogenic and oxidative pathways. J Biol Chem, 280, 35983-35991.
  • Desmarais J, Bennett RD, Gevry N, Murphy BD, 2002. The role of peroxisome proliferator-activated receptor δ (PPARδ) in the process of implantation in the mink (Mustela vison). Biol Reprod, 67 (Suppl.1), 63 (abst).
  • Desvergne B, Wahli W, 1999. Control of metabolism by PPARs. Endocr Rev, 20, 649-688.
  • Ding NZ, Ma XH, Diao HL, Xu LB, Yang ZM, 2003a. Differen- tial expression of peroxisome proliferator-activated re- ceptor delta at implantation sites and in decidual cells of rat uterus. Reproduction, 125, 817-825.
  • Ding NZ, Teng CB, Ma H, Ni H, Ma XH, Xu LB, Yang ZM, 2003b. Peroxisome proliferator-activated receptor delta ex- pression and regulation in mouse uterus during embryo implantation and decidualization. Mol Reprod Dev, 66, 218-224.
  • Emond V, MacLaren LA, Kimmins S, Arosh JA, Fortier MA, Lambert RD, 2004. Expression of cyclooxygenase-2 and granulocyte-macrophage colony-stimulating factor in the endometrial epithelium of the cow is up-regulated during early pregnancy and in response to intrauterine infusions of interferon-tau. Biol Reprod, 70, 54-64.
  • Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B, 2001. Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology, 142, 4195-4202.
  • Faddy HM, Robinson JA, Lee WJ, Holman NA, Monteith GR, Roberts-Thomson SJ, 2006. Peroxisome proliferator- activated receptor α expression is regulated by estrogen receptor α and modulates the response of MCF-7 cells to sodium butyrate. Int J Biochem Cell Biol, 38, 255-266.
  • Fauti T, Uller-Brusselbach S, Kerutzer M, Rieck M, Meissner W, RappU, Schweer H, Komhoff M, Muller R, 2006. In- duction of PPARbeta and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARbeta. FEBS J, 273, 669-671.
  • Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W, 2006. From molecular action to physiological outputs: peroxi- some proliferator-activated receptors are nuclear re- ceptors at the crossroads of key cellular functions. Prog Lipid Res, 45, 120-59.
  • Fournier T, Tsatsaris V, Handschuh K, Evain-Brion D, 2007. PPARs and the placenta. Placenta, 28, 65-76.
  • Guzeloglu A, Bilby TR, Meikle A, Kamimura S, Kowalski A, Michel F, MacLaren LA, Thatcher WW, 2004. Pregnancy and bovine somatotropin in nonlactating dairy cows: II. Endometrial gene expression related to maintenance of pregnancy. J Dairy Sci, 87, 3268-3279.
  • Han S, Ritzenthaler JD, Wingerd B, Roman J, 2005. Activa- tion of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer- binding protein beta. J Biol Chem, 280, 33240-33249.
  • He TC, Chan TA, Vogelstein B, Kinzler KW, 1999. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, 99, 335-345.
  • Kalajdzic T, Faour WH, He QW, Fahmi H, Martel-Pelletier J, Pelletier JP, Di Battista JA, 2002. Nimesulide, a preferen- tial cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxy- genase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. Arthritis Rheum, 46, 494-506.
  • Krey G, Braissant O, L’Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W, 1997. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxi- some proliferator-activated receptors by coactivator- dependent receptor ligand assay. Mol Endocrinol, 11, 779-791.
  • Larsen LK, Amri EZ, Mandrup S, Pacot C, Kristiansen K, 2002. Genomic organization of the mouse peroxisome proliferator-activated receptor β/δ gene: alternative promoter usage and splicing yield transcripts exhibit- ing differential translational efficiency. J Biochem, 366, 767-775.
  • Lee JY, Hwang DH, 2002. Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated recep- tors in a colon tumor cell line. Biochem Biophys Res Commun, 298, 667-674.
  • Lim H, Gupta RA, Ma W, Paria BC, Moller DE, Morrow JD, Du- Bois RN, Trzaskos JM, Dey SK, 1999. Cyclo-oxygenase-2- deprived prostacyclin mediates embryo implantation in the mouse via PPARδ. Gene Dev, 13, 1561-1574.
  • Liu SF, Haddad E, Adcock I, Salmon M, Koto H, Gilbey T, 1995. Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rats. Amer J Physiol, 37, 331-338.
  • Lord E, Murphy BD, Desmarais JA, Ledoux S, Beaudry D, Pal- in MF, 2006. Modulation of peroxisome proliferator-ac- tivated receptor delta and gamma transcripts in swine endometrial tissue during early gestation. Reproduc- tion, 131, 929-942.
  • MacLaren LA, Guzeloglu A, Michel F, Thatcher WW, 2006. Peroxisome proliferator-activated receptor (PPAR) expression in cultured bovine endometrial cells and response to omega-3 fatty acid, growth hormone and agonist stimulation in relation to series 2 prostaglandin production. Domest Anim Endocrinol, 30, 155-169.
  • Mattos R, Staples CR, Williams J, Amorocho A, McGuire MA, Thatcher WW, 2002. Uterine, ovarian and production responses of lactating dairy cows to increasing dietary concentrations of menhaden fish meal. J Dairy Sci, 85, 755-764.
  • Meade EA, McIntyre TM, Zimmerman GA, Prescott SM, 1999. Peroxisome proliferators enhance cyclooxygenase-2 ex- pression in epithelial cells. J Biol Chem, 274, 8328-8334.
  • Moreira F, Badinga L, Burnley C, Thatcher WW, 2002. Bo- vine somatotropin increases embryonic development in superovulated cows and improves post-transfer preg- nancy rates when given to lactating recipient cows. The- riogenology, 57, 1371-1387.
  • Nunez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH, 1998. Retinoid X receptor and peroxisome proliferator-activated receptor activated an estrogen responsive gene independent of the estrogen receptor. Mol Cell Endocrinol, 127, 27-40.
  • Perez MA, Hansen RA, Harris MA, Allen KG, 2006. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase pro- duction. J Nutr Biochem, 17, 446-453.
  • Santos JE, Juchem SO, Cerri RL, Galvao KN, Chebel RC, Thatcher WW, Dei CS, Bilby CR, 2004. Effect of bST and reproductive management on reproductive perfor- mance of Holstein dairy cows. J Dairy Sci, 87, 868-881.
  • Sethi S, Ziouzenkova O, Heyu N, Wagner DD, Plutzky J, Maya- das TN, 2002. Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through acti- vation of PPARα. Blood, 100, 1340-1346.
  • Silvestre FT, Carvalho TSM, Francisco N, Santos JEP, Staples CR, Jenkins TC, Thatcher WW, 2011. Effects of differen- tial supplementation of fatty acids during the peripar- tum and breeding periods of Holstein cows: I. Uterine and metabolic responses, reproduction and lactation. J Dairy Sci, 94, 189-204.
  • Sundvold H, Brzozowska A, Lien S, 1997. Characterisation of bovine peroxisome proliferator-activated receptors gamma 1 and gamma 2: genetic mapping and differen- tial expression of the two isoforms.Biochem Biophys Res Commun, 239, 857-861.
  • Thatcher WW, Bilby TR, Bartolome JA, Silvestre F, Staples CR, Santos JEP, 2006. Strategies for improving fertility in the modern dairy cow. Theriogenology, 65, 30-44.
  • Wamsley NE, Burns PD, Engle TE, Enns RM, 2005. Fish meal supplementation alters uterine prostaglandin F2alpha synthesis in beef heifers with low luteal-phase proges- terone. J Anim Sci, 83, 1832-1838.
  • Zhou YC, Waxman DJ, 1999. Cross-talk between janus ki- nase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated re- ceptor α (PPARα) signaling pathways. J Biol Chem, 274, 2672-2681.
Toplam 47 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA69MM44YZ
Bölüm Araştırma
Yazarlar

Leslie A. Maclaren Bu kişi benim

Todd R Bilby Bu kişi benim

Frank Michel Bu kişi benim

Aydin Guzeloglu Bu kişi benim

Charles R. Staples Bu kişi benim

William W. Thatcher. Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 27 Sayı: 4

Kaynak Göster

APA Maclaren, L. A., Bilby, T. R., Michel, F., Guzeloglu, A., vd. (2011). Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors. Eurasian Journal of Veterinary Sciences, 27(4), 207-218.
AMA Maclaren LA, Bilby TR, Michel F, Guzeloglu A, Staples CR, Thatcher. WW. Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors. Eurasian J Vet Sci. Aralık 2011;27(4):207-218.
Chicago Maclaren, Leslie A., Todd R Bilby, Frank Michel, Aydin Guzeloglu, Charles R. Staples, ve William W. Thatcher. “Supplementation of Dairy Cows With Bovine Somatotropin or Omega-3 Rich Fish Oil Affects the Endometrial Expression of Peroxisome Proliferator-Activated Receptors”. Eurasian Journal of Veterinary Sciences 27, sy. 4 (Aralık 2011): 207-18.
EndNote Maclaren LA, Bilby TR, Michel F, Guzeloglu A, Staples CR, Thatcher. WW (01 Aralık 2011) Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors. Eurasian Journal of Veterinary Sciences 27 4 207–218.
IEEE L. A. Maclaren, T. R. Bilby, F. Michel, A. Guzeloglu, C. R. Staples, ve W. W. Thatcher., “Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors”, Eurasian J Vet Sci, c. 27, sy. 4, ss. 207–218, 2011.
ISNAD Maclaren, Leslie A. vd. “Supplementation of Dairy Cows With Bovine Somatotropin or Omega-3 Rich Fish Oil Affects the Endometrial Expression of Peroxisome Proliferator-Activated Receptors”. Eurasian Journal of Veterinary Sciences 27/4 (Aralık 2011), 207-218.
JAMA Maclaren LA, Bilby TR, Michel F, Guzeloglu A, Staples CR, Thatcher. WW. Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors. Eurasian J Vet Sci. 2011;27:207–218.
MLA Maclaren, Leslie A. vd. “Supplementation of Dairy Cows With Bovine Somatotropin or Omega-3 Rich Fish Oil Affects the Endometrial Expression of Peroxisome Proliferator-Activated Receptors”. Eurasian Journal of Veterinary Sciences, c. 27, sy. 4, 2011, ss. 207-18.
Vancouver Maclaren LA, Bilby TR, Michel F, Guzeloglu A, Staples CR, Thatcher. WW. Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors. Eurasian J Vet Sci. 2011;27(4):207-18.