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Yıl 2018, Cilt: 4 Sayı: 3, 220 - 226, 04.07.2018
https://doi.org/10.18621/eurj.347720

Öz

Kaynakça

  • [1] Lumeng JC, Chervin RD. Epidemiology of pediatric obstructive sleep apnea. Proc Am ThoracSoc 2008;15:242-52.
  • [2] Schlaud M, Urschitz MS, Urschitz-Duprat PM, Poets CF. The German study on sleep-disordered breathing in primary school children: epidemiological approach, representativeness of study sample, and preliminary screening results. Pediatr Perinat Epidemiol 2004;18:431-40.
  • [3] Mira E, Benazzo M, Asti L, Marchi A, Spirano P, Losi R. Iron status in children undergoing tonsillectomy and its short-term modification following surgery. Acta Otolaryngol 1988;454:261-4.
  • [4] Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol 2006;13:158-65.
  • [5] Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Sziagyi PG. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 2001;107:1381-6.
  • [6] Angulo-Kinzler RM, Peirano P, Lin E, Garrido M, Lozoff B. Spontaneous motor activity in human infants with iron-deficiency anemia. Early Hum Dev 2002;66:67-79.
  • [7] Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007;51:301-23.
  • [8] Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr 2001;131:616-33.
  • [9] Zilberman M, Silverberg DS, Bits I, Steinbruch S, Wexler D, Sheps D et al. Improvement of anemia with erythropoietin and intravenous iron reduces sleep-related breathing disorders and improves daytime sleepiness in anemic patients with congestive heart failure. Am Heart J 2007;154:870-6.
  • [10] Benz RL, Pressman MR, Hovick ET, Peterson DD. A preliminary study of the effects of correction of anemia with recombinant human erythropoietin therapy on sleep, sleep disorders, and daytime sleepiness in hemodialysis patients (The SLEEPO study). Am J Kidney Dis 1999;34:1089-95.
  • [11] Elverland HH, Aasand G, Miljeteig H, Ulvik RJ. Effects of tonsillectomy and adenoidectomy on hemoglobin and iron metabolism. Int J Pediatr Otorhinolaryngology 2004;68:419-23.
  • [12] Busuttil A, Kerr AI, Logan RW. Iron deficiency in children undergoing adenoid-tonsillectomy. J Laryngol Otol 1979;93:49-58.
  • [13] Kerstein R, Stimpson P, Caulfield H, Ellis G. Iron deficiency and sleep disordered breathing in children--cause or effect? Int J Pediatr Otorhinolaryngol 2009;73:275-80.
  • [14] Guilleminault C, Kirisoglu C, Ohayon MM. C-reactive protein and sleep-disordered breathing. Sleep 2004;27:1507-11.
  • [15] Barcelo A, Barbe F, Llompart E, Mayoralas LR, Ladaria A, Bosch M, et al. Effects of obesity on C-reactive protein level and metabolic disturbances in male patients with obstructive sleep apnea. Am J Med 2004;117:118-21.
  • [16] Ciftci TU, Kokturk O, Bukan N, Bilgihan A. The relationship be¬tween serum cytokine levels with obesity and obstructive sleep apnea syndrome. Cytokine 2004;28:87-91.
  • [17] Gozal D, Serpero LD, Sans Capdevila O, Kheirandish-Gozal L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med 2008;62:489-94.
  • [18] Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
  • [19] Sharifkashani S, Dabirmoghaddam P, Kheirkhah M, Hosseinzadehnik R. A new clinical scoring system for adenoid hypertrophy in children. Iran J Otorhinolaryngol 2015;27:55-61.
  • [20] Bitar MA, Rahi A, Khalifeh M, Madana LMS. A suggested clinical score to predict the severity of adenoid obstruction in children. Eur Arch Otorhinolaryngol 2006;263:924-8.
  • [21] Brodsky L. Modern assessment of tonsils and adenoids. Pediatr Clin North Am 1989;36:1551-69.
  • [22] Parikh SR, Coronel M, Lee JJ, Brown SM. Validation of a new grading system for endoscopic examination of adenoid hypertrophy. Otolaryngol Head Neck Surg 2006;135:684-7.
  • [23] Moy RJ. Prevalence, consequences and prevention of childhood nutritional iron deficiency: a child public health perspective. Clin Lab Haematol 2006;28:291-8.
  • [24] Iron deficiency anemia: assessment, prevention and control, A guide for program managers. (WHO web site) 2001. Available at: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en/ Accessed January 13, 2017.
  • [25] GrandoneA ,Marzuillo P, Perrone L, Giudice EM. Iron metabolism dysregulation and cognitive dysfunction in pediatric obesty: Is there a connection? Nutrients 2015;7:9163-70.
  • [26] Dyugovskaya L, Lavie P, Lavie L. Lymphocyte activation as a possible measure of atherosclerotic risk in patients with sleep apnea. Ann N Y Acad Sci 2005;1051:340-50.
  • [27] O’Brien LM, Koo J, Fan L, Owusu JT, Chotinaiwattarakul W, Felt BT, Chervin RD. Iron stores, periodic leg movements, and sleepiness in obstructive sleep apnea. J Clin Sleep Med 2009;5:525-31.
  • [28] Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 2009;32:447-50.
  • [29] Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant 2004;19:141-9.
  • [30] Rambod M, Kovesdy CP, Kalantar-Zadeh K. Combined high serum ferritin and low iron saturation in hemodialysis patients: the role of inflammation. Clin J Am Soc Nephrol 2008;3:1691-701.
  • [31] Dündar Y, Tatar EÇ, Saylam G, Korkmaz H, Selçuk OT, et al. The evaliation of inflammatory process, endothelial dysfunction and oxidative stress in sleep apnea. J Med Updates 2014;4:61-5.

Is anemia in children with sleep disordered breathing actually a consequence of chronic disease?

Yıl 2018, Cilt: 4 Sayı: 3, 220 - 226, 04.07.2018
https://doi.org/10.18621/eurj.347720

Öz

Objective. We aimed to investigate iron metabolism and
laboratory findings of anemia in children undergoing adenotonsillectomy for
sleep disordered breathing. Methods. Consecutive children
undergoing adenoidectomy/adenotonsillectomy for sleep disordered breathing
between January 2013 and January 2015 were investigated. Routine preoperative
blood tests including blood count and iron studies were analyzed. Subgroup
analyses were performed addressing to the severity of sleep disordered
breathing, age and duration of symptoms. Results were compared between subgroups
and normal values. Results. The study included
171 children. The mean age was 5.44 ± 2.62 years. The mean hemoglobin level was
11.87 ± 1.125
gr/dL and 24 (14%) out of 171
patients had anemia (< 11 gr/dL). The mean ferritin levels were 23.23 ± 17.27
µg/L and 21.27 ± 15.44 µg/L in patients with anemia and non-anemic
patients, respectively (p = 0.572).
Ferritin levels decreased in only 8 (33%) out of 24 patients with anemia. The
mean age, body mass index, hematocrit, mean corpuscular volume, unsaturated
iron binding capacity and serum iron levels decreased in patients with anemia. The
rate of anemia significantly increased in children less than or equal to 3 years
of age (p = 0.020). There was no
significant association between hemoglobin levels and sleep disordered
breathing clinical score or duration of symptoms. Conclusion. The association
between low iron status and sleep disordered breathing has previously
published. Unfortunately, the type of anemia is still unclear. Our results
supposed that the anemia of chronic disease secondary to chronic inflammatory
process might play a role in pathogenesis of anemia in patients with sleep
disordered breathing. 

Kaynakça

  • [1] Lumeng JC, Chervin RD. Epidemiology of pediatric obstructive sleep apnea. Proc Am ThoracSoc 2008;15:242-52.
  • [2] Schlaud M, Urschitz MS, Urschitz-Duprat PM, Poets CF. The German study on sleep-disordered breathing in primary school children: epidemiological approach, representativeness of study sample, and preliminary screening results. Pediatr Perinat Epidemiol 2004;18:431-40.
  • [3] Mira E, Benazzo M, Asti L, Marchi A, Spirano P, Losi R. Iron status in children undergoing tonsillectomy and its short-term modification following surgery. Acta Otolaryngol 1988;454:261-4.
  • [4] Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol 2006;13:158-65.
  • [5] Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Sziagyi PG. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 2001;107:1381-6.
  • [6] Angulo-Kinzler RM, Peirano P, Lin E, Garrido M, Lozoff B. Spontaneous motor activity in human infants with iron-deficiency anemia. Early Hum Dev 2002;66:67-79.
  • [7] Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007;51:301-23.
  • [8] Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr 2001;131:616-33.
  • [9] Zilberman M, Silverberg DS, Bits I, Steinbruch S, Wexler D, Sheps D et al. Improvement of anemia with erythropoietin and intravenous iron reduces sleep-related breathing disorders and improves daytime sleepiness in anemic patients with congestive heart failure. Am Heart J 2007;154:870-6.
  • [10] Benz RL, Pressman MR, Hovick ET, Peterson DD. A preliminary study of the effects of correction of anemia with recombinant human erythropoietin therapy on sleep, sleep disorders, and daytime sleepiness in hemodialysis patients (The SLEEPO study). Am J Kidney Dis 1999;34:1089-95.
  • [11] Elverland HH, Aasand G, Miljeteig H, Ulvik RJ. Effects of tonsillectomy and adenoidectomy on hemoglobin and iron metabolism. Int J Pediatr Otorhinolaryngology 2004;68:419-23.
  • [12] Busuttil A, Kerr AI, Logan RW. Iron deficiency in children undergoing adenoid-tonsillectomy. J Laryngol Otol 1979;93:49-58.
  • [13] Kerstein R, Stimpson P, Caulfield H, Ellis G. Iron deficiency and sleep disordered breathing in children--cause or effect? Int J Pediatr Otorhinolaryngol 2009;73:275-80.
  • [14] Guilleminault C, Kirisoglu C, Ohayon MM. C-reactive protein and sleep-disordered breathing. Sleep 2004;27:1507-11.
  • [15] Barcelo A, Barbe F, Llompart E, Mayoralas LR, Ladaria A, Bosch M, et al. Effects of obesity on C-reactive protein level and metabolic disturbances in male patients with obstructive sleep apnea. Am J Med 2004;117:118-21.
  • [16] Ciftci TU, Kokturk O, Bukan N, Bilgihan A. The relationship be¬tween serum cytokine levels with obesity and obstructive sleep apnea syndrome. Cytokine 2004;28:87-91.
  • [17] Gozal D, Serpero LD, Sans Capdevila O, Kheirandish-Gozal L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med 2008;62:489-94.
  • [18] Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
  • [19] Sharifkashani S, Dabirmoghaddam P, Kheirkhah M, Hosseinzadehnik R. A new clinical scoring system for adenoid hypertrophy in children. Iran J Otorhinolaryngol 2015;27:55-61.
  • [20] Bitar MA, Rahi A, Khalifeh M, Madana LMS. A suggested clinical score to predict the severity of adenoid obstruction in children. Eur Arch Otorhinolaryngol 2006;263:924-8.
  • [21] Brodsky L. Modern assessment of tonsils and adenoids. Pediatr Clin North Am 1989;36:1551-69.
  • [22] Parikh SR, Coronel M, Lee JJ, Brown SM. Validation of a new grading system for endoscopic examination of adenoid hypertrophy. Otolaryngol Head Neck Surg 2006;135:684-7.
  • [23] Moy RJ. Prevalence, consequences and prevention of childhood nutritional iron deficiency: a child public health perspective. Clin Lab Haematol 2006;28:291-8.
  • [24] Iron deficiency anemia: assessment, prevention and control, A guide for program managers. (WHO web site) 2001. Available at: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en/ Accessed January 13, 2017.
  • [25] GrandoneA ,Marzuillo P, Perrone L, Giudice EM. Iron metabolism dysregulation and cognitive dysfunction in pediatric obesty: Is there a connection? Nutrients 2015;7:9163-70.
  • [26] Dyugovskaya L, Lavie P, Lavie L. Lymphocyte activation as a possible measure of atherosclerotic risk in patients with sleep apnea. Ann N Y Acad Sci 2005;1051:340-50.
  • [27] O’Brien LM, Koo J, Fan L, Owusu JT, Chotinaiwattarakul W, Felt BT, Chervin RD. Iron stores, periodic leg movements, and sleepiness in obstructive sleep apnea. J Clin Sleep Med 2009;5:525-31.
  • [28] Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 2009;32:447-50.
  • [29] Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant 2004;19:141-9.
  • [30] Rambod M, Kovesdy CP, Kalantar-Zadeh K. Combined high serum ferritin and low iron saturation in hemodialysis patients: the role of inflammation. Clin J Am Soc Nephrol 2008;3:1691-701.
  • [31] Dündar Y, Tatar EÇ, Saylam G, Korkmaz H, Selçuk OT, et al. The evaliation of inflammatory process, endothelial dysfunction and oxidative stress in sleep apnea. J Med Updates 2014;4:61-5.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Article
Yazarlar

Fatih Alper Akcan

Yusuf Dündar Bu kişi benim

Hümeyra Bayram Akcan Bu kişi benim

Ahmet Uluat

Derya Cebeci Bu kişi benim

Mehmet Ali Sungur

Yayımlanma Tarihi 4 Temmuz 2018
Gönderilme Tarihi 30 Ekim 2017
Kabul Tarihi 4 Aralık 2017
Yayımlandığı Sayı Yıl 2018 Cilt: 4 Sayı: 3

Kaynak Göster

AMA Akcan FA, Dündar Y, Bayram Akcan H, Uluat A, Cebeci D, Sungur MA. Is anemia in children with sleep disordered breathing actually a consequence of chronic disease?. Eur Res J. Temmuz 2018;4(3):220-226. doi:10.18621/eurj.347720

e-ISSN: 2149-3189 


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