Yıl 2019, Cilt 5 , Sayı 6, Sayfalar 948 - 956 2019-11-04

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Ahmed Ramiz Baykan [1] , Cemile Biçer [2] , Emre Gerçeker [3] , Özcan Erel [4] , Serkan Cerrah [5] , Bülent Albayrak [6] , Mustafa Utlu [7] , Ayşe Kargılı [8]


Objectives: The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with Helicobacter pylori infection, using a novel marker (thiol/disulphide homeostasis) and to compare the level in infected individuals with that in healthy volunteers.

Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein) LDL and thiol/disulphide levels obtained in the study groups were compared.

Results: There was no significant difference between the total thiol, native thiol, disulphide/native thiol and dissulphide/total thiol ratios of the patient and control group. When the H. pylori patients were stratified by endoscopic evaluation as having mild (superficial gastritis or normal appearance) or severe (ulcer or erosive areas) symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thiol and native thiol/total thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patients were inversely related.( r: 0.562, p = 0.001; r: 0.0552, p = 0.002).

Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pylori infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.

Helicobacter pylori, thiol, oxidative stress
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Birincil Dil en
Konular Endokrinoloji ve Metabolizma, Biyokimya ve Moleküler Biyoloji, Gastroenteroloji ve Hepatoloji, Genel ve Dahili Tıp
Bölüm Original Article
Yazarlar

Orcid: 0000-0001-6798-0240
Yazar: Ahmed Ramiz Baykan (Sorumlu Yazar)
Kurum: Department of Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Ülke: Turkey


Orcid: 0000-0001-7937-4475
Yazar: Cemile Biçer
Kurum: Department of Biochemistry, Yıldırım Beyazit University School of Medicine, Ankara, Turkey
Ülke: Turkey


Orcid: 0000-0001-7494-2912
Yazar: Emre Gerçeker
Kurum: Department of Gastroenterology, İzmir Gazi Hospital, İzmir, Turkey
Ülke: Turkey


Orcid: 0000-0002-2996-3236
Yazar: Özcan Erel
Kurum: Department of Biochemistry, Yıldırım Beyazit University School of Medicine, Ankara, Turkey
Ülke: Turkey


Orcid: 0000-0002-9139-8039
Yazar: Serkan Cerrah
Kurum: Department of Gastroenterology, Elazığ Medikalpark Hospital, Elazığ, Turkey
Ülke: Turkey


Orcid: 0000-0003-1231-152X
Yazar: Bülent Albayrak
Kurum: Department of Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Ülke: Turkey


Orcid: 0000-0002-6148-6644
Yazar: Mustafa Utlu
Kurum: Department of Internal Medicine, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Ülke: Turkey


Orcid: 0000-0002-5622-9563
Yazar: Ayşe Kargılı
Kurum: Department of Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 4 Kasım 2019

EndNote %0 The European Research Journal Thiol/disulphide homeostasis in Helicobacter pylori infected patients %A Ahmed Ramiz Baykan , Cemile Biçer , Emre Gerçeker , Özcan Erel , Serkan Cerrah , Bülent Albayrak , Mustafa Utlu , Ayşe Kargılı %T Thiol/disulphide homeostasis in Helicobacter pylori infected patients %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 6 %R doi: 10.18621/eurj.443557 %U 10.18621/eurj.443557