Ekotoksikoloji Alanında Balık Hücre Hatlarının Kullanımı

Yıl 2018, Cilt: 29 Sayı: 2, 175 - 180, 30.12.2018

Aylin Pehlivan Enes Atmaca Abdurrahman Aksoy

https://doi.org/10.35864/evmd.513576

Öz

Son yıllarda, pratik ve etik nedenlerle, ekotoksikolojide in vitro yöntemlere olan ilgi artmıştır. Sitotoksisite çalışmalarında hücre kültürü uygulamaları, in vivo çalışmalardan elde edilen sonuçlara uyumluluğu ve hücresel düzeyde inceleme olanağı gibi avantajlarıyla, diğer in vitro yöntemlere göre öne çıkmıştır. Balık hücre kültürleriyle yapılan çalışmalar, kimyasal maddelerin toksik ve çevresel etkilerinin değerlendirilmesine imkan sağlamaktadır. Ekotoksikolojide, kimyasal maddelerin toksik ve çevresel etkilerinin değerlendirilmesinde RTG-2, RTL-W1, PLHC-1 ve EPC gibi çeşitli balık hücre hatları sıklıkla tercih edilmektedir. Bu derlemede, balık hücre hatlarının ekotoksikoloji çalışmalarında kullanımları ve dikkat edilmesi gereken bazı hususlar ele alınmıştır.

Anahtar Kelimeler

Çevresel kirleticiler, ekotoksikoloji, balık hücre hattı

Kaynakça

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