SAD B19'un Türk Köpeklerindeki Etkinlik Çalışmaları

Yıl 1998, Cilt: 9 Sayı: Özel Sayı, 93 - 101, 01.06.1998

Orhan Aylan Ad Vos

Öz

Yerli ırk Türk köpekleri SAD B 19 canlı modifiye virus aşısının fmklı
konsantrasyonları kullanılarak ağız yolu ile aşılanmıştır. İmmun yanıtın izlenmesi
için düzenli aralıklarla kan örnekleri alınmıştır. 1 x 10⁸ FFU'nun
üzerinde doz ile kabul edilebilir serum dönüşüm düzeyleri elde edildiği gözlenmiştir.
10 köpekten 9'u aşılamadan 479 gün sonra 1.5 x 10⁸ FFU luk
eprüvasyona (direkt olarak ağız boşluğuna akıtınal direnç göstermiştir. 2.1
x10⁷ FFU ile doldurulmuş aşı kapsülü içeren bait verilerek aşılanmış 16
köpekten sadece 3'ünde serum dönüşümü gözlenmiştir. Bununla birlikte
hiç kuduz nötrölizan antikoruna sahip olmayan birkaç köpek aşılamadan
74 gün sonraki eprüvasyona direnç göstermiştir.

Anahtar Kelimeler

Sad B19, Türk, Köpek

Efficacy Studies With SAD B 19 in Turkish Dogs

Öz

Local Turkish dogs were vaccinated orally with the live moclifiecl virus
vaccine SAD B 19 , using different concentrations . To monitor the immune
response bloodsamples were taken at regular intervals. Among others. dogs
were vaccinated with 2. 1 x 10⁷ FFU orally (bait) but developed no detectable .
level of rabies virus neutralizing antibodies. Several of these dogs, however.
resisted challenge 74 days after vaccination. It was shown that acceptable
levels of seroconversion were achieved with dosage of more than
1 x 10⁸ FFU SAD B 19. N ine out of 10 dogs resisted challenge 479 days
after vaccination with 1.5 x 10⁸ FFU SAD B19 by direct instillation into the
mouth cavity.

Kaynakça

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