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SAD B19'un Türk Köpeklerindeki Etkinlik Çalışmaları

Yıl 1998, Cilt: 9 Sayı: Özel Sayı, 93 - 101, 01.06.1998

Öz

Yerli ırk Türk köpekleri SAD B 19 canlı modifiye virus aşısının fmklı
konsantrasyonları kullanılarak ağız yolu ile aşılanmıştır. İmmun yanıtın izlenmesi
için düzenli aralıklarla kan örnekleri alınmıştır. 1 x 10⁸ FFU'nun
üzerinde doz ile kabul edilebilir serum dönüşüm düzeyleri elde edildiği gözlenmiştir.
10 köpekten 9'u aşılamadan 479 gün sonra 1.5 x 10⁸ FFU luk
eprüvasyona (direkt olarak ağız boşluğuna akıtınal direnç göstermiştir. 2.1
x10⁷ FFU ile doldurulmuş aşı kapsülü içeren bait verilerek aşılanmış 16
köpekten sadece 3'ünde serum dönüşümü gözlenmiştir. Bununla birlikte
hiç kuduz nötrölizan antikoruna sahip olmayan birkaç köpek aşılamadan
74 gün sonraki eprüvasyona direnç göstermiştir.

Kaynakça

  • Brochier B, Blancou J, Thomas I, Languet B, Artois M, Kieny M-P, Lecocq J-P, Costy F, Desmettre P, Chappuis G, Pastoret P-P (1989) Use orrecombinant vaccina-rabies glycoproteiıı virus for oral vaccination or wildlife against rabies: innocuity to several non-target bait consuming species . J. Wilcll. Dis .. 25: 540-547.
  • Chomel B, Chappuis G. Bullon F, Cardenas E, David de Beublain T, Lombard M, Giambruno E (1988) Mass vaccination ccımpaign against rabies: are dogs correctly protected ? The Peruvian experience. Rev. Infect. Dis .. 10:697-702 .
  • Frontini MG, Fishbein DB, Ramos JG, Collins EF, Balderas JMB, Quiroz Huerta G, Gamez Roderiguez J de J, Belotto AJ, Dobbins JG, Linhart SB, Baer GM (1992) A field evaluation in Mexico of four baits tör oral rabies vaccination of dogs. Am. J. Trop. Med. Hyg., 47: 310-3 H)
  • Haddad N, Blancou J, Gritli A, Ben Osman F, Koutchoukali MA, Aubert MFA ( 1985) Activite de deux vaccins antirabiques employes lors de la primo-vaccination ele chiens ltot venanti en Tunisie. Recueil ele Medicine Vetcrinaire . 161: 755-762
  • Müller Th, Schlüter H (1998) Oral immunization of reel foxes Vulpes vulpes L.) in Europe - a review. J . Etlik Vet. Microbiol.. 9:35-60
  • Müller WW, Güzel T, Aylan O, Kaya C, Cox JH, Schneider LG ( 1998) The feasibility of oral vaccination of dogs in Turkey - a European Union supportecl project. J. Etlik Vet. Microbiol.. 9:61-71
  • Perry BD, W andeler AI (1993) The clelivery of oral rabies vaccines to dogs: an African perspective. Onclerstepoort J. of Vet. Res .. 60:451-457.
  • Precausta P, Soulebot JP, Chappuis G, Brun A, Bugand M, Petermann HG (1985) NIL 2 cell inactivatecl tissue culture vaccine against rabies: immunization of carnivores. In: Rabies in the tropics (eels. Kuwcrt E. Merieux C. Koprowski H. Bögel K) 227-240. Springer Verlag. Berlin.
  • Rooijakkers EJM, Nieuwenhuijs JHM, Vermeulen AA, Steenis van G ( 1996) Potency of veterinary rabies vaccines in the Netherlancls: A case tör continuecl vigilance. Vet. Quart .. 18:146-150
  • Schumacher CL, Coulon P, Lafay F, Benejeaıi J, Aubert MF A, Barrat J, Aubert A, Flamand A (ı993) SAG-2 oral rabies vaccine. Onclerstepoort J . Vet. Res .. 60:459-462.
  • Sihvonen L, Kulonen K, Neuvonen E, Pekkanen K (1995) Rabies anti-boclies in vaccinateel dogs. Acta vet. scand., 36:87-91.
  • Tepsumetanon W, Polsuwan C, Lumlertdaecha B, Khawplod P, Hema-chudha T, Chutivongse S, W ilde H, Chiewbamrungkiat M, Phanuphak P (1991) Immune response to rabies vaccine in Thai elogs: a preliminary report. Vaccine, 9: 627-630.
  • Wandeler AI (1991)Oral Immunization of Wildlife. In: The Natural History of Rabies. 2nd ed. (ed. Baer GM) 485-503, CRC Press. Boca Raton

Efficacy Studies With SAD B 19 in Turkish Dogs

Yıl 1998, Cilt: 9 Sayı: Özel Sayı, 93 - 101, 01.06.1998

Öz

Local Turkish dogs were vaccinated orally with the live moclifiecl virus
vaccine SAD B 19 , using different concentrations . To monitor the immune
response bloodsamples were taken at regular intervals. Among others. dogs
were vaccinated with 2. 1 x 10⁷ FFU orally (bait) but developed no detectable .
level of rabies virus neutralizing antibodies. Several of these dogs, however.
resisted challenge 74 days after vaccination. It was shown that acceptable
levels of seroconversion were achieved with dosage of more than
1 x 10⁸ FFU SAD B 19. N ine out of 10 dogs resisted challenge 479 days
after vaccination with 1.5 x 10⁸ FFU SAD B19 by direct instillation into the
mouth cavity.

Kaynakça

  • Brochier B, Blancou J, Thomas I, Languet B, Artois M, Kieny M-P, Lecocq J-P, Costy F, Desmettre P, Chappuis G, Pastoret P-P (1989) Use orrecombinant vaccina-rabies glycoproteiıı virus for oral vaccination or wildlife against rabies: innocuity to several non-target bait consuming species . J. Wilcll. Dis .. 25: 540-547.
  • Chomel B, Chappuis G. Bullon F, Cardenas E, David de Beublain T, Lombard M, Giambruno E (1988) Mass vaccination ccımpaign against rabies: are dogs correctly protected ? The Peruvian experience. Rev. Infect. Dis .. 10:697-702 .
  • Frontini MG, Fishbein DB, Ramos JG, Collins EF, Balderas JMB, Quiroz Huerta G, Gamez Roderiguez J de J, Belotto AJ, Dobbins JG, Linhart SB, Baer GM (1992) A field evaluation in Mexico of four baits tör oral rabies vaccination of dogs. Am. J. Trop. Med. Hyg., 47: 310-3 H)
  • Haddad N, Blancou J, Gritli A, Ben Osman F, Koutchoukali MA, Aubert MFA ( 1985) Activite de deux vaccins antirabiques employes lors de la primo-vaccination ele chiens ltot venanti en Tunisie. Recueil ele Medicine Vetcrinaire . 161: 755-762
  • Müller Th, Schlüter H (1998) Oral immunization of reel foxes Vulpes vulpes L.) in Europe - a review. J . Etlik Vet. Microbiol.. 9:35-60
  • Müller WW, Güzel T, Aylan O, Kaya C, Cox JH, Schneider LG ( 1998) The feasibility of oral vaccination of dogs in Turkey - a European Union supportecl project. J. Etlik Vet. Microbiol.. 9:61-71
  • Perry BD, W andeler AI (1993) The clelivery of oral rabies vaccines to dogs: an African perspective. Onclerstepoort J. of Vet. Res .. 60:451-457.
  • Precausta P, Soulebot JP, Chappuis G, Brun A, Bugand M, Petermann HG (1985) NIL 2 cell inactivatecl tissue culture vaccine against rabies: immunization of carnivores. In: Rabies in the tropics (eels. Kuwcrt E. Merieux C. Koprowski H. Bögel K) 227-240. Springer Verlag. Berlin.
  • Rooijakkers EJM, Nieuwenhuijs JHM, Vermeulen AA, Steenis van G ( 1996) Potency of veterinary rabies vaccines in the Netherlancls: A case tör continuecl vigilance. Vet. Quart .. 18:146-150
  • Schumacher CL, Coulon P, Lafay F, Benejeaıi J, Aubert MF A, Barrat J, Aubert A, Flamand A (ı993) SAG-2 oral rabies vaccine. Onclerstepoort J . Vet. Res .. 60:459-462.
  • Sihvonen L, Kulonen K, Neuvonen E, Pekkanen K (1995) Rabies anti-boclies in vaccinateel dogs. Acta vet. scand., 36:87-91.
  • Tepsumetanon W, Polsuwan C, Lumlertdaecha B, Khawplod P, Hema-chudha T, Chutivongse S, W ilde H, Chiewbamrungkiat M, Phanuphak P (1991) Immune response to rabies vaccine in Thai elogs: a preliminary report. Vaccine, 9: 627-630.
  • Wandeler AI (1991)Oral Immunization of Wildlife. In: The Natural History of Rabies. 2nd ed. (ed. Baer GM) 485-503, CRC Press. Boca Raton
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Orhan Aylan Bu kişi benim

Ad Vos Bu kişi benim

Yayımlanma Tarihi 1 Haziran 1998
Gönderilme Tarihi 1 Ocak 998
Yayımlandığı Sayı Yıl 1998 Cilt: 9 Sayı: Özel Sayı

Kaynak Göster

APA Aylan, O., & Vos, A. (1998). SAD B19’un Türk Köpeklerindeki Etkinlik Çalışmaları. Etlik Veteriner Mikrobiyoloji Dergisi, 9(Özel Sayı), 93-101.


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