MUP-PCL-TEO-PVA Bilayer Nanofiber Scaffold Incorporated with Mupirocin and Thyme Essential Oil for Synergistic Activity Against Bacterial Wound Infections.

Yıl 2024, , 163 - 180, 26.03.2024

Kisan Jadhav , Shivani Gharat Shradha Adhalrao

https://doi.org/10.55262/fabadeczacilik.1346469

Öz

Electrospinning process was used for constructing the bilayer nanofibers scaffold using drug and oil
containing polymeric emulsion for synergistic activity against bacterial wound infections. The
characterization was done for morphology, chemical composition, thermal behaviour, porosity,
swelling ratio, drug release, in vitro permeation, ex vivo studies, and antimicrobial activity. In vitro
drug permeation study, exhibited initial rapid release of MUP upto 53% in the first 6 hrs and
following a slower sustained release achieving 92.17% drug release in 72 hours whereas TEO showed
release in 10 hrs with initial burst release followed by sustained release achieving 85.45% release. The
ex vivo skin permeation data revealed greater permeability compared to conventional films.
Antibacterial activity of the bilayer nanofiber scaffold was found to be greater than that of single layer
MUP and TEO scaffold as zone of inhibition of MUP-PCL-TEO-PVA bilayer scaffold was greater
which indicates the synergistic activity of MUP and TEO.

Anahtar Kelimeler

Bilayer nanofiber scaffold, Wound infections, Mupirocin, synergistic activity, Thyme essential oil, Antibacterial activity

Kaynakça

• Thakur R.A., Florek C. A., Kohn J., Michniak B.B. (2008)Electrospunnanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. International Journal of Pharmaceutics, 364, 87–93. https://doi. org/10.1016/j.ijpharm.2008.07.033.3,