Modified Drug Release from SiO2/Polyhydroxybutyrate Composite Prepared Using Bamboo Leaf-Derived Silica

Yıl 2022, Cilt: 1 Sayı: 47, 23 - 34, 01.03.2022

Enobong R. Essıen

https://doi.org/10.55262/fabadeczacilik.1078768

Cited By: 1

Öz

The ability of a controlled or modified drug delivery system to supply the drug in a sustained way and assure on-demand bioavailability makes it preferable to traditional drug administration. Due to the reliance on alkoxysilane silica precursors, the preparation of silica/ polymer composite delivery material is costly. As a result, this study looked into using the bamboo leaf as a silica starting material. To evaluate in vitro degradability and modified-release in phosphate buffered saline (PBS) solution, the ash from the bamboo leaf was
mixed with polyhydroxy butyrate (PHB) solution to make a (SiO2/PHB) composite, which was then loaded with the medication, tetracycline hydrochloride (TCH). The shape, phase composition, and chemical bond characteristics of the materials were evaluated using scanning electron microscopy (SEM), X-ray diffractometry (XRD), and Fourier transform infrared spectroscopy. An ultraviolet (UV) spectrophotometer was used to determine the TCH release profile. The SiO2/PHB composite was found to have a successful drug loading ability. In addition to regulated degradability in PBS, the composite exhibited a steady and sustained TCH release, with the degradation solution pH remaining below safe limits. As a result, the formulation of SiO2/PHB for continuous TCH delivery from bamboo leaf-derived silica suggests a significant potential economic benefit for a safe, regulated drug delivery method.

Anahtar Kelimeler

Bamboo leaf, alkoxysilanes, composites, modified drug release, silica, tetracycline hydrochloride.

Bambu Yaprağından Elde Edilen Silika Kullanılarak Hazırlanan SiO2/Polihidroksibutirat Kompozitten Modifiye İlaç Salımı

Öz

Kontrollü veya modifiye edilmiş ilaç salım sistemleri, ilacı sürekli vermesi ve istenilen biyoyararlanımı sağlaması nedeniyle konvansiyonel ilaç uygulama sistemlerine göre tercih edilmektedirler. Alkoksisilan silika prekürsörlerine bağlı olarak silika/polimer kompozitlerin taşıyıcı malzeme olarak üretilmeleri pahalıdır. Sonuç olarak, bu çalışma bambu yaprağını silika başlangıç malzemesi olarak kullanmayı amaçlamıştır. İn vitro bozunmayı ve modifiye edilmiş salımı fosfat tamponlu tuz çözeltisinde (PBS) değerlendirmek için, tetrasiklin hidroklorür (TCH) ile yüklenen bir (SiO2/PHB) kompozit yapmak için bambu yaprağından gelen kül, polihidroksibütirat (PHB) çözeltisi ile karıştırılmıştır. Malzemelerin şekli, faz bileşimi
ve kimyasal bağ özellikleri, taramalı elektron mikroskobu (SEM), X-ışını difraktometrisi (XRD) ve Fourier dönüşümü kızılötesi spektroskopisi kullanılarak değerlendirildi. TCH salınım profilini belirlemek için bir ultraviyole (UV) spektrofotometre kullanıldı. SiO2/PHB kompozitinin başarılı bir ilaç yükleme yeteneğine sahip olduğu bulundu. İlave olarak PBS’de düzenlenmiş bozunabilirliğe ek olarak, kompozitin, bozunma çözeltisi pH’ının güvenli sınırların altında kalmasıyla, TCH’yi sabit ve sürekli bir şekilde saldığı bulundu. Sonuç olarak, bambu yaprağından türetilen silikadan sürekli TCH salımı için Si02/PHB formülasyonu, güvenli, düzenlenmiş bir ilaç verme yöntemi olarak önemli bir potansiyel ekonomik fayda sağlayacaktır.

Anahtar Kelimeler

Bambu yaprağı, Alkoksisilan, kompozitler, modifiye edilmiş ilaç salımı, silika, tetrasiklin hidroklorür.

Kaynakça

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