Synthesis and Antibacterial Evaluation of Novel Benzimidazole, Benzothiazole, Benzofurane, and Naphtofurane Derivatives of Aminothiazoles

Yıl 2022, Cilt: 47 Sayı: 2, 231 - 240, 01.08.2022

Zafer Şahin Büşra Işıl Tok Erol Akgün Erol Akgün Ayşegül Çaşkurlu Leyla Yurttaş Barkın Berk Şeref Demirayak

Öz

The thiazole ring is the core of bioactive molecules that
generate broad activity. These activities include anticonvulsant,
antimicrobial, antituberculosis, antiviral, etc. In this work, starting
from seconder/cyclic amines, new compounds containing thiazole
and benzimidazole/benzothiazole/benzofurane/naphtofurane rings
were synthesized, and their antimicrobial effects were evaluated. 9
compounds were synthesized by converting the seconder and cyclic
amines to thiourea, and continued by thiazole ring closure. Ring
closure was achieved by methylene-carbonyl condensation except
conventional methods. Compound characterization was realized by
FT-IR, 1H NMR and 13C NMR and HRMS. Compounds did not
show significant activity on bacterial strains. Nine aminothiazole
derivatives have been synthesized successfully. Compounds did not
show important antibacterial activity and thus were evaluated as
inactive.

Anahtar Kelimeler

antibacterial, aminothiazole, benzothiazole, benzofurane, naphtofurane

Kaynakça

• Althagafi, I., El-Metwaly, N., & Thoraya, A. F. (2019). New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking. Molecules, 24, 1741. doi: 10.3390/molecules24091741.