Development of Innovative Cosmetic Formulations to Help Fungal Treatment and Testing the Efficiency of Formulations

Yıl 2022, Cilt: 47 Sayı: 3, 347 - 354, 19.10.2022

Gülgun Yener , Caner Acar , Berna Özbek , Emel Mataracı Kara

https://doi.org/10.55262/fabadeczacilik.1100973

Öz

In the fungus of hands and toenails, the thickening of the nail and its yellow color are the first signs of attention. Fungus on the nails of the hands and feet is often caused by Trichophyton rubrum dermatophyte. They have antifungal properties due to the components found in lavender oil, geranium oil and tea tree oil structures. Oral antifungal agents used for treatment of nail fungi have serious side effects especially on liver. Therefore, topical applications have been given importance in recent years. However, in topical applications antifungal agents have difficulties in sending to the target area. For this reason, nanoemulsion technology was preferred in the study. Nanoemulsion formulations of essential oils were prepared using ultrasonication method. Centrifugal and thermal test were applied as preliminary stability to the formulations and the pH value, viscosity, droplet size and polidispersity index of the formulations passing this step were measured and organoleptic controls were performed. Antifungal efficacy and release studies were performed on the formulations F4P3-I (pelargonium), F4P3-L (lavender), F4P3-C (tea tree) and F4P3-K (mixture) which were successful as a result of all the tests. According to the study, it was concluded that F4P3-I, F4P3-L, F4P3-Ç, F4P3-K formulations may help in the treatment of fungi.

Anahtar Kelimeler

lavender oil, geranium oil, tea tree oil, nanoemulsion, ultrasonication

Proje Numarası

32758

Kaynakça

• Referans1 Aboofazeli, R. (2010). Nanometric Scaled Emulsions (Nanoemulsion). Iranian Journal of Pharmaceutical Research, 9(4), 325-326. doi:10.22037/IJPR.2010.897
• Referans2 Anton, N., & Vandamme, T. (2009). The Universality of Low-Energy Nano-Emulsification. International Journal Pharmaceuticals, 377(1-2), 142-147. doi:10.1016/j.ijpharm.2009.05.014
• Referans3 Carpenter, J., & Saharan, V.K. (2016). Ultrasonic assisted formulation and stability of mustard oil in water nanoemulsion: Effect of process parameters and their optimization. Ultrasonics Sonochemistry, 35, 422-430. doi:10.1016/j.ultsonch.2016.10.021
• Referans4 Denning, D.W., Evans, E.G., Kibbler, C.C., and et al. (1995). Fungal nail disease: a guide to good practice. BMJ, 311:1277-81. doi:10.1136/bmj.311.7015.1277
• Referans5 Elewski, B.E., Rich, P., Tosti, A., Pariser, D.M., Scher, R., Daniel, R.C., & Gupta, A.K. (2013). Onychomycosis: An Overview. Journal Drugs Dermatol, 12, 96-103.
• Referans6 Graves, S., Meleson, K., & Wilking, J. (2005). Structure of Concentrated Nanoemulsions. Journal of Chemical Physics, 122(13). doi:10.1063/1.1874952
• Referans7 Hosseini, S., Tarzi, B.G., Gharachorloo, M., Ghavami, M., & Bakhada, H. (2015). Optimization on the Stability of Linseed Oil-in Water Nanoemulsions Generated by Ultrasonic Emulsification Using Response Surface Methodology (RSM). Orient J Chem., 31(2),1223-1230. doi: 10.13005/ojc/310282
• Referans8 Jafari, S.M., He, Y., & Bhandari, B. (2007). Optimization of Nanoemulsion Production by Microfluidization. European Food Research Technology, 225(5-6), 733-741. doi: 10.1007/s00217-006-0476-9
• Referans9 Kreijkamp-Kaspers, S., Hawke, K., Guo, L., Kerin, G., Bell-Syer, S.E., Magin, P., Bell-Syer, S.V., & Van Driel, M.L. (2017). Oral antifungal medication for toenail onychomycosis. Cochrane Database Syst. Rev. 7, Cd010031. doi:10.1002/14651858.CD010031.pub2.
• Referans10 Li, X., Anton, N., Ta, T.M.C., Zhao, M., Messaddeq, N., & Vandamme, T.F. (2011). Microencapsulation of Nanoemulsions: Novel Trojan Particles for Bioactive Lipid Molecule Delivery. International Journal of Nanomedicine, Vol. 6, 1313-1325. doi:10.2147/IJN.S20353 Marszall, L. (1975). Cosmet. Parfum., 90, 37.
• Referans11 Mason, T.G., Graves, S.M., Wilking, J.N., & Lin, M.Y. (2006). Extreme Emulsification: Formation and Structure of Nanoemulsions. Journal of Physics and Condensed Matter, Vol. 9, 1, 193-199. doi: 10.5488/CMP.9.1.193
• Referans12 Ruth, H.S., Attwood, D., Ktistis, G., & Taylor, C. (1995). Phase Studies and Particle Size Analysis of Oil-in-Water Phospholipid Microemulsions. International Journal of Pharmaceuticals. Vol. 116, 2, 253-261. doi:10.1016/0378-5173(94)00316-W
• Referans13 Salouti, M., Kazemi, D., Rostamizadeh, K., & Zabihian, A. (2014). Development of gentamicin-loaded solid lipid nanoparticles: evaluation of drug release kinetic and antibacterial activity against Staphylococcus aureus. International Journal of Pharmaceutical Research and Innovation, Vol. 7, 1-6.
• Referans14 Shah, P., Bhalodia, D., & Shelat, P. (2010). Nanoemulsion: A-Pharmaceutical Review. Systematic Reviews in Pharmacy, Vol. 1, 1, 24-32. doi:10.4103/0975-8453.59509
• Referans15 Shin, S., & Lim, S. (2004). Antifungal effects of herbal essential oils alone and in combination with ketoconazole against Trichophyton spp. Journal of Applied Microbiology, 97, 1289-1296. doi: 10.1111/j.1365-2672.2004.02417.x
• Referans16 Shinoda, K., & Friberg, S.E. (1986). Emulsions and Solubilization, New York: Wiley-Intersicence. doi:10.1002/JCTB.280420311
• Referans17 Tadros, T., Izquierdo, P., Esquena, J., & Solans, C. (2004). Formation and Stability of Nanoemulsions. Advances in Colloids and Interface Science, Vol. 108-109, 303-318. doi: 10.1016/j.cis.2003.10.023