Dipyridamole cocrystal tablets with enhanced solubility and dissolution at intestinal pH

Yıl 2024, Cilt: 49 Sayı: 1, 37 - 50, 26.03.2024

Monika Nijhawan Sadhana Dhyagala Sailaja Gunnam Rajeswari Aleti Dr Trapti Saxena

https://doi.org/10.55262/fabadeczacilik.1318448

Öz

The aim of the study was to prepare dipyridamole(DPM) cocrystals to alter itsphysicochemical properties as it ispoorly soluble in water, 6.8 pHbuffer and belongs to BCS class II. Cocrystals were prepared usingneat grinding method.
Initial screening of cocrystals was done with melting point determination indicating formation of nine cocrystals. Based upon interference studies nine cocrystalswere finalized for solubility and dissolution studies. DPM-citric acid, DPM-hippuric acid, DPM-tartaric acid and DPM-oxalic acid cocrystalsshowed the significant enhancement in solubility and dissolution in 6.8 pH buffer.Further confirmation was done by DSC and PXRD studies. DPM-hippuric acid cocrystalshave shownpromising results for formation of cocrystals and considered for tablet formulation. DPM-hippuric acid cocrystal tablets were prepared by using various levels of carboxymethyl cellulose and microcrystalline cellulose. These tablets showed acceptable physical characteristics with subsequent rapid dissolution.

Anahtar Kelimeler

Dipyridamole(DPM), Cocrystals, Neatgrinding, DSC, Solubility, Dissolution.

Destekleyen Kurum

Nil

Proje Numarası

Nil

Teşekkür

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Kaynakça

• Bevill, M. J., Vlahova, P. I., & Smit, J. P. (2014). Polymorphic cocrystals of nutraceutical compound p-coumaric acid with nicotinamide: Characterization, relative solid-state stability, and conversion to alternate stoichiometries. Crystal growth & design, 14(3), 1438-1448.