Öz
This research investigates the formulation and assessment of gelatine capsules containing a microemulsion of ODN aimed at improving its bioavailability and therapeutic effectiveness. ODN a commonly utilized antiemetic, is characterized by low oral bioavailability primarily due to significant first-pass metabolism. To mitigate this challenge, a microemulsion system was developed utilizing a blend of oil, surfactant, and co-surfactant, which was subsequently encapsulated within gelatine capsules. The resulting capsules were analysed for their drug excipient interactions, drug release profile etc, ensuring that the formulation possessed optimal characteristics for enhanced drug delivery. Findings indicated that the microemulsion-based gelatine capsules markedly enhanced the dissolution rate of ODN, indicating a viable strategy for addressing its bioavailability challenges. This study presents an innovative formulation approach that holds potential for improving the therapeutic efficacy of ODN in clinical applications.
Anahtar Kelimeler
Microemulsion Ondansetron hydrochloride Gelatine capsule spectroscopy quality control
Kaynakça
- Ahmadi, F., Alipour, S., & Akbari, S. (2015). Development and in vitro evaluation of fast-dissolving oral films of ondansetron hydrochloride, Trends in Pharmaceutical Sciences, 1(1), 25- 30. https://tips. sums.ac.ir Abruzzo, A., Bigucci, F., Cerchiara, T., Gallucci, M. C., Luppi, B., Saladini, B., & Trastullo, R. (2016). Design and evaluation of buccal films as paediatric dosage form for transmucosal delivery of ondansetron, European Journal of Pharmaceutics and Biopharmaceutics, 105, 115-121. https:// www.sciencedirect.com/journal/european-journal-of-pharmaceutics-and-biopharmaceutics
Öz
This research investigates the formulation and assessment of gelatine capsules containing a microemulsion of ODN aimed at improving its bioavailability and therapeutic effectiveness. ODN a commonly utilized antiemetic, is characterized by low oral bioavailability primarily due to significant first-pass metabolism. To mitigate this challenge, a microemulsion system was developed utilizing a blend of oil, surfactant, and co-surfactant, which was subsequently encapsulated within gelatine capsules. The resulting capsules were analysed for their drug excipient interactions, drug release profile etc, ensuring that the formulation possessed optimal characteristics for enhanced drug delivery. Findings indicated that the microemulsion-based gelatine capsules markedly enhanced the dissolution rate of ODN, indicating a viable strategy for addressing its bioavailability challenges. This study presents an innovative formulation approach that holds potential for improving the therapeutic efficacy of ODN in clinical applications.
Anahtar Kelimeler
Microemulsion Ondansetron hydrochloride Gelatine capsule spectroscopy quality control
Kaynakça
- Ahmadi, F., Alipour, S., & Akbari, S. (2015). Development and in vitro evaluation of fast-dissolving oral films of ondansetron hydrochloride, Trends in Pharmaceutical Sciences, 1(1), 25- 30. https://tips. sums.ac.ir Abruzzo, A., Bigucci, F., Cerchiara, T., Gallucci, M. C., Luppi, B., Saladini, B., & Trastullo, R. (2016). Design and evaluation of buccal films as paediatric dosage form for transmucosal delivery of ondansetron, European Journal of Pharmaceutics and Biopharmaceutics, 105, 115-121. https:// www.sciencedirect.com/journal/european-journal-of-pharmaceutics-and-biopharmaceutics
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İlaç Dağıtım Teknolojileri |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 26 Ağustos 2025 |
| Gönderilme Tarihi | 11 Aralık 2024 |
| Kabul Tarihi | 24 Nisan 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 50 Sayı: 2 |
