Endometriyal Reseptiviteyi Anlamak: Başarılı İmplantasyonda Önemli Bir Faktör

Yıl 2023, , 39 - 43, 30.12.2023

Deniz Kulaksız

https://doi.org/10.59518/farabimedj.1306708

Öz

Embriyonun başarılı bir şekilde implantasyonu, sağlıklı bir hamilelik elde etmede çok önemli bir kilometre taşıdır. Endometriumun, embriyo implantasyonuna açık hale geldiği kısa dönem olan implantasyon penceresi, bu sürecin başarısını veya başarısızlığını belirlemede çok önemli bir rol oynar. Bu makale, endometrial reseptiviteyi etkileyen faktörlere ve bunun başarılı implantasyon elde etmedeki önemine kapsamlı bir genel bakış sunmayı amaçlamaktadır. İmplantasyon penceresi sırasında endometriyumda meydana gelen fizyolojik değişiklikler, hormonal, moleküler ve hücresel olaylar karmaşık bir etkileşim göstermektedir. Başta östrojen ve progesteron olmak üzere yumurtalık hormonlarının bu değişiklikleri yönetmedeki kritik rolü vardır ve bunların endometrial büyüme, farklılaşma ve reseptivite üzerindeki etkileri vardır. Endometriyal reseptivite için çeşitli moleküler belirteçler ve sinyal yolları mevcuttur. Bunlar integrinleri, adezyon moleküllerini, sitokinleri, büyüme faktörlerini ve bunların etkileşimlerini içerir; bunların hepsi embriyo tutunması ve invazyon için çok önemlidir. Anormal endometriyal reseptivitenin implantasyon başarısızlığı, tekrarlayan gebelik kaybı ve kısırlık üzerinde etkisi bulunmaktadır. Sonuç olarak, endometrial reseptiviteyi yöneten karmaşık mekanizmaların anlaşılması, reprodüktif sonuçların iyileştirilmesi için çok önemlidir. Reseptivitenin değerlendirilmesi ve optimize edilmesi ile doğurganlık tedavilerinin başarı oranlarını artırma mümkün olabilir.

Anahtar Kelimeler

Endometriyal reseptivite, HOXA10, Kısırlık

Understanding Endometrial Receptivity: A Key Factor in Successful Implantation

Öz

Successful implantation of the embryo is a crucial milestone in achieving a healthy pregnancy. The implantation window, the short period in which the endometrium becomes open to embryo implantation, plays a crucial role in determining the success or failure of this process. This article aims to provide a comprehensive overview of the factors affecting endometrial receptivity and its importance in achieving successful implantation. Physiological changes, hormonal, molecular and cellular events that occur in the endometrium during the implantation window show a complex interaction. Ovarian hormones, particularly estrogen and progesterone, have a critical role in managing these changes and have effects on endometrial growth, differentiation, and receptivity. Various molecular markers and signaling pathways exist for endometrial receptivity. These include integrins, adhesion molecules, cytokines, growth factors and their interactions; All of these are very important for embryo attachment and invasion. Abnormal endometrial receptivity has implications for implantation failure, recurrent pregnancy loss, and infertility. In conclusion, understanding the complex mechanisms governing endometrial receptivity is crucial for improving reproductive outcomes. By evaluating and optimizing receptivity, it may be possible to increase the success rates of fertility treatments.

Anahtar Kelimeler

Endometrial receptivity, HOXA10, Infertility

Kaynakça

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