Chronic Tobacco Snuff-Induced Columellar Squamous Cell Carcinoma: A Case Report

Öz

In this article, we presented a 57-year-old woman with a history of snuff abuse for 16 years and developed squamous cell carcinonoma in the columellar skin. Primary cancer of nasal columella is extremely rare. This is a very agressive tumor and if not resected adequately it can easily spread to adjacent structures.. These tumors should be treated radically. The tumor was resected and defect was reconstructed with left nasolabial sulcus flap in this case. Close follow-up is required because of high recurrence rate. We try to discuss the behavior of these tumors, staging, treatment modalities and prognostic factors.

Anahtar Kelimeler

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Kronik Olarak Buruna Tütün Çekimine Bağlı Skuamoz Hücreli Karsinom: Olgu Sunumu

Öz

Bu yazıda 16 yıldır burnuna tütün çekme hikayesi olan ve kolumellar ciltte skuamoz hücreli kanser gelişen 57 yaşında bayan hastayı sunduk. Nazal kolumellanın primer kanseri oldukça nadirdir. Bu çok agresif olan ve yeterince rezeke edilmediğinde kolaylıkla çevre yapılara yayılabilen bir tümördür. Bu tümörler radikal olarak tedavi edilmelidir. Bu vakada tümör rezeke edildi ve oluşan defekt nazolabial sulkus flebiyle rekonstrukte edildi. Yüksek rekürrans oranı nedeniyle yakın takip gereklidir. Bu tümörlerin davranışı, evrelemesi ve tedavi seçeneklerini tartışmaya çalıştık.

Anahtar Kelimeler

• Tütün çekimi, Nazal kolumella, Skuamoz hücreli karsinom

Kaynakça

1. 1. Oriba HA, Snow SN. Tumours of the nasal columella treated by Mohs micrographic surgery. Laryngoscope 1997; 107: 1647–1650.
2. 2. Conley J. Cancer of the skin of the nose. Ann Otol Rhinol Laryngol 1974; 83: 2-8.
3. 3. Fornelli RA, Fedok FG, Wilson EP, Rodman SM. Squamous cell carcinoma of the anterior nasal cavity: a dual institution review. Otolaryngol Head Neck Surg 2000; 123: 207–210.
4. 4. Choussy O, Babin E, Temam S, et al. Squamous cell carcinoma of nasal of nasal columella: a retrospective study of 66 cases from the GETTEC. Eur Arch of Otorhinolaryngol 2008; 265: 35-41.
5. 5. Maruyama Y, Iwahira Y. The axial nasodorsum flap, Plast Reconstr Surg 1997; 99; 1873-1877.
6. 6. Mignogna FV, Garay KF. Surgical rescue of recurrent carcinoma of the nasal columella. Am J Surg 1996; 170: 453- 456.
7. 7. Mendenhall NP, Parsons JT, Cassisi NJ. Carcinoma of the nasal vestibule treated with radiation therapy. Laryngoscope 1987; 97: 626–632.
8. 8. Sreedharan S, Hegde MC, Pai R, et al. Snuff-induced malignancy of the nasal vestibule: a case report. Am J Otolaryngol 2007; 28: 353-356.

9. 9. Sapundzhiev N, Werner JA. Nasal snuff: historical review and health related aspects. J Laryngol Otol 2003; 117: 686-691.
10. 10. Koppang N, Rivenson A, Dahle HK, et al. A study of tobacco carcinogenesis, LIII: carcinogenicity of N Vnitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) in mink (Mustela vison). Cancer Lett 1997; 111: 167-171.
11. 11. Larsson PA, Johansson SL, Vahlne A, et al. Snuff tumorigenesis: effects of long-term snuff administration after initiation with 4- nitroquinolone- N -oxide and herpes simplex virus type 1. J Oral Pathol Med 1989; 18: 187-191.
12. 12. Wang CC. Treatment of carcinoma of the nasal vestibule by irradiation. Cancer 1976; 38: 100–106.
13. 13. Wong CS, Cummings BJ, Elkhakim T, Briant TD. External irradiation for squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys 1986; 12: 1943–1946.