The Levels of Vitamine A in Laryngeal Carcinoma

Öz

Objectives: To investigate the level of vitamin A which cause the inhibition of the cell proliferation and induction of the cell differantation in the carcinoma of the larynx. Materials and Methods: This study included the 29 patients who had the carcinoma of the larynx. Mean age of the patients was 58,7±7,4. All of the patients were male and none of them were using vitamins. Levels of Vitamin A were evaluated in all patients. Findings were compared with control group that included 32 subjects. Results: Asignificant decrease was seen in the levels of vitamin A in patients with carcinoma of the larynx when compared with the levels of vitamin A in control group(p

Anahtar Kelimeler

• -

Larenks Epidermoid Kanserinde Vitamin A Düzeyi

Öz

Amaç: Hücre proliferasyonunun inhibisyonu ve hücresel diferansiyasyon indüksiyonuna neden olan A Vitamini'nin larenks karsinomunda düzeyini araştırmak. Gereç ve Yöntem: Çalışmaya 29 larenks epidermoid karsinomlu hasta alındı. Yaş ortalaması 58,7±7,4 idi. Hastaların tümü erkek ve daha önceden vitamin kullanım hikayesi yoktu. Tüm hastaların A vitamini düzeyleri ölçüldü ve 32 kişilik kontrol grubu ile karşılaştırıldı. Bulgular: Hasta grubunun Vitamin A düzeyleri kontrol grubu ile karşılaştırıldığında hasta grubun Vitamin A düzeylerinde anlamlı düzeyde düşük olduğu (p

Anahtar Kelimeler

• Larenks karsinomu, vitamin A

Kaynakça

1. Goodman DS: Vitamin A and Retinoids in Health and Disease. N Engl J Med 1984; 310: 1023-1031.
2. Watson RR, Leonard TK:Selenium and Vitamins A, E and C:Nutritients with Cancer revention Properties. Am Diet Assoc J 1986; 86: 505-510.
3. Sporn MB, Robents AB: The role of retinoids in differantation and carcinogenesis. Cancer Res 1983; 43: 3034-3040,.
4. Lippman SM, Kessler JF, Meyskens FL: Retinoids as preventive and therapeutic anticancer agents. Cancer tratment reports 1987; 71: 391-405.
5. Strickland,S. and Mahdavi, V., The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell, 1978; 15: 393- 403.
6. Lotan R., Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cell. Biochemica Biophysica Acta, 1980,605,33-91.
7. Ingeborg Klaassen, Boudewijn J.M. Braakhuis. Anticancer activity and mechanism of action of retinoids in oral and pharyngeal cancer. Oral Oncology 2002; 38: 532-542.
8. Gudas LJ, Sporn MB, Roberts AB. Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids. Biology, chemistry and medicine. 2nd ed. New York: 1994: 443-520.

9. Menkes MS, Comstock GW, Vuilleumier JP, Helsing JK, Rider AA, Brookmeyer R: Serum beta carotene, vitamins A and E, selenium and the risk of lung cancer. N. Engl J Med 1986; 315: 1250-1254.
10. Wynder EL, Bross IJ (1961) A Study of etiological factors in cancer of the esophagus. Cancer 14: 389-398.
11. Mayne ST, Risch HA, Dubrow R, et al (2001) Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 10: 1055-1062.
12. Richard M. Niles PhD. Recent advances in the use of Vitamin A (Retinoids) in the prevention and treatment of cancer. Nutrition 2000, 16: 1084-1090.
13. Wald N, Idle M, Boreham J, Bailey A. Low serum-vitamin A and subsequent risk of cancer. Preliminary results of a prospective study. Lancet 1980; II: 813-815.
14. Zheng W, Blot WJ, Diamond EL, et al. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Research 1993; 53: 795-798.
15. Fontham ET. Protective dietary factors and lung cancer. Int J Epidemiol 1990; 19: S32-0S42.
16. Klaassen I, Brakenhoff RH, Smeets SJ, Snow GB, Braakhuis BJ. Enhanced turnover of all-trans-retinoic acid and increased formation of polar metabolites in head and neck squamous cell carcinoma lines compared with normal oral keratinocytes. Clin Cancer Res 2001; 7: 1017-1025.
17. Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, et al. 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 1986; 315: 1501-1505.
18. Schepman KP, van der Meij EH, Smeele LE, van der Waal I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol 1998; 34: 270- 275.
19. Braakhuis BJM, TaborMPT, Leemans CR, Van der Waal I, Snow, GB, Brakenhoff Rh. Second primary tumors and field cancerization in oral and oropharyngeal cancer:molecular techniques provide new insights and definitions. Head Neck, 2001.
20. Haughey, B.H., Gates, G.A., Arfken, C.L. and Harvey,J. Meta- analysis of second malignant tumors in head and neck cancer: The case for an endoscopic screening protocol. Annals of Otology, Rhinology and Laryngology, 1992; 101: 105-112
21. Hong, W.K., Lippman, S.M, Itri, L.M., et al. Prevention of second primary tumors with isotrenoin in squamous-cell carcinoma of the head and neck. New England Journal of Medicine, 1990; 323: 795-801
22. Shi-Yong Sun, Reuben Lotan. Retinoids and their receptors in cancer development and chemoprevention. Critical Reviews in Oncology Hematology 41 (2002): 41-55.
23. Benner SE, Pajak TF, Lippman SM, Earley C, Hong WK. Prevention of second primary tumors with isotretinoin in patients with squamous cell carcinoma of the head and neck: long-term follow-up. J Natl Cancer Inst. 1994; 86: 140-141.
24. Hong WK, Itri LM. Retinoids and human and cancer. In: Sporn MB, Roberts SB, Goodman DS, editors. The retinoids. New York: Raven Press, 1994: 597-658.
25. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996; 10: 940-945.
26. Drozdz M, Gierek T, Jendryczko Apiekarska J, Pilch J, Polanska D: Zinc, Vitamins A and E, and Retinol-Binding Protein in Sera or Patients with Cancer of the Larynx. Neoplasm 36; 1989: 357- 362.
27. Picker H, Bichler E: Nutritional and Immunological Investigations in Head and Neck Cancer Patients Before and After Therapy. Arch Otolaryngol 1985; 242: 149-153.
28. Kabul Tarihi:30.03.2005