The Insertion\Deletion Polymorphism of Angiotensin Converting Enzyme is Associated with Major Depression

Yıl 2012, Cilt: 17 Sayı: 3, 153 - 155, 01.06.2012

Murat Kara Bilge Kara Deniz Erol Hüseyin Yüce Murad Atmaca İbrahim Tekedereli

Öz

Objective: Major depression is a relatively common psychiatric disorder. The etiology remains to be elucidated. In this study, we investigated the relationship between major depression and the insertion\deletion polymorphism of angiotensin converting enzyme gene. Materials and Methods: The DNAs from patients (n=133) and healthy volunteers (n=119) were analysed by polymerase chain reaction (PCR). Results: The genotype (p

Anahtar Kelimeler

-

Anjiyotensin Dönüştürücü Enzim İnsersiyon\Delesyon Polimorfizmi Major Depresyon Hastalığıyla İlişkilidir

Öz

Amaç: Major depresyon toplumda sıkça karşılaşılan bir psikiyatrik bozukluktur. Birçok faktör suçlanmakla birlikte etyolojisi henüz tam olarak aydınlatılamamıştır. Bu çalışmamızda anjiyotensin dönüştürücü enzim (ADE) insersiyon (I)\ delesyon (D) polimorfizmi ile major depresyon arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Yüzotuzüç hasta 119 sağlıklı bireyden elde edilen DNA'lar polimeraz zincir reaksiyonu (PCR) yöntemi ile analiz edildi. Bulgular: Anjiyotensin dönüştürücü enzim insersiyon delesyon genotipleri (p

Anahtar Kelimeler

Major depresyon, Anjiotensin Dönüştürücü Enzim, Polimorfizm

Kaynakça

• Sayed-Tabatabaei FA, Oostra BA, Isaacs A, van Duijn CM, Witteman JC. ACE polymorphisms. Circ Res 2006; 98: 1123- 33.
• Mendelsohn FA, Hutchinson JS, Csicsmann J. Angiotensin converting enzyme in the brain of spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 1980; 7: 551-54.
• Baghai TC, Schule C, Zwanzger P, et al. Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression. Neurosci Lett 2003; 339: 223-26.
• Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998; 281: 1640-45.
• Muders F, Elsner D, Jandeleit K, et al. Chronic ACE inhibition by quinapril modulates central vasopressinergic system. Cardiovasc Res 1997; 34: 575-81.
• Madaan V, Wilson DR. Neuropeptides: relevance in treatment of depression and anxiety disorders. Drug News Perspect 2009; 22: 319-24.
• Tiret L, Rigat B, Visvikis S, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992; 51: 197-205.
• Rudnicki M, Mayer G. Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. Pharmacogenomics 2009; 10: 463-76.
• Liu SY, Sima X, Wang CH, Gao M. The association between ACE polymorphism and risk of colorectal cancer in a Chinese population. Clin Biochem 2011; 44: 1223-26.
• Lukic S, Nikolic A, Alempijevic T, et al. Angiotensin- converting enzyme gene insertion/deletion polymorphism in patients with chronic pancreatitis and pancreatic cancer. Dig Surg 2011; 28: 258-62.
• Wu Y, Wang X, Shen X, Tan Z, Yuan Y. The I/D polymorphism of angiotensin-converting enzyme gene in major depressive disorder and therapeutic outcome: A case- control study and meta-analysis. J Affect Disord 2012; 136: 971-78.
• Özen NE, Koçak OM, Doğru T, Sayın DB. Anjiotensin dönüş- türücü enzim polimorfizminin anksiyete ve depresyon düzeyi- ne etkisi. Anadolu Psikiyatri Dergisi 2009; 10: 181-86.
• Gönderilme Tarihi: 06.06.2012