Yıl 2012,
Cilt: 17 Sayı: 2, 118 - 120, 01.04.2012
Öz
Propofol, gama amino bütirik asit (GABA) reseptörleri üzerinden eksitatör nörotransmitterlere inhibitör etki gösteren, genel anestezi ve sedasyon için yaygın olarak kullanılan intravenöz bir ilaçtır. Propofol, antikonvülzan bir ilaç olarak da tanınmaktadır. Fakat kullanımına bağlı olarak birçok nörolojik yan etkiler bildirilmiştir. Bu olgu sunumunda, sedasyon amaçlı tek doz propofol uygulanmasına bağlı olarak, genç bir bayanda gelişen myoklonik kasılma sunulmuştur.
Anahtar Kelimeler
Kaynakça
- 1. Jungheinrich C, Scharpf R, Wargenau M, Dilger C, Bepperling F. Pharmacokinetics of the generic formulation propofol 1% fresenius in comparison with the original formulation (Disoprivan 1%) Clin Drug Investig 2002; 22: 417–27.
- 2. Walder B, Tramer MR, Seeck M. Seizure-like phenomena and propofol: a systematic review. Neurology 2002; 58: 1327–32. 3. Jung SH, Kim TW, Jung KY, Kim JM. A case of propofolinduced seizure-like phenomena. Korean J Epilepsy Soc 2003; 7: 51–3.
- 4. Finley GA, MacManus B, Sampson SE, Fernandez CV, Retallick R. Delayed seizures following sedation with propofol. Can J Anaesth 1993; 40: 863–5.
- 5. Manikandan S, Sinha PK, Neema PK, Rathod RC. Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. Anesth Analg 2005; 100: 1468-9. 6. Islander G, Vinge E. Severe neuroexcitatory symptoms after anaesthesia with focus on propofol anaesthesia. Acta Anaesthesiologica Scandinavica 2000; 44: 144–9.
- 7. AstraZeneca. Issued to the medical profession only ‘Diprivan’ 1%. Insert of Diprivan P016791 2004.
- 8. Dearlove JC, Dearlove OR. Cortical reflex myoclonus after propofol anaesthesia. Anaesthesia 2002; 57: 834–5.
- 9. Borgeat A, Dessibourg C, Popovic V, Meier D, Blanchard M, Schwander D. Propofol and spontaneous movements: an EEG study. Anesthesiology 1991; 74: 24–7.
- 10. Makela JA, Livanainen M, Pieninkeroinen IP, Waltimo O, Lahdensuu M. Seizures associated with propofol anesthesia. Epilepsia 1993; 34: 832–5.
- 11. Lowson S, Gent JP, Goodchild S. Anticonvulsant properties of propofol and thiopental comparison using two tests in laboratory mice. Br J Anaesth 1990; 64: 59-63.
- 12. Stecker MM, Kramer TH, Raps EC, O’Meeghan R, Dulaney E, Skaar DJ. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia 1998; 39: 18-26.
- 13. Leikin JB, Benigno J, Dubow JS, Fisher M. Status epilepticus due to tiagabine digestion. Am J Ther 2008; 15: 290-2. 14. Borgeat A. Propofol: pro- or anticonvulsant? Eur J Anaesthesiol 1997; 14: 17-20.
- 15. Sutherland MJ, Burt P. Propofol and seizures. Anaesth Intensive Care 1994; 22: 733-7.
- 16. Bendiksen A, Larsen LM. Convulsions, ataxia, and hallucinations following propofol. Acta Anaesthesiol Scand 1998; 42: 739-41.
Yıl 2012,
Cilt: 17 Sayı: 2, 118 - 120, 01.04.2012
Öz
Propofol, a GABA-mediated inhibitor of excitatory neurotransmitter, is a widely used intravenous agent for general anaesthesia and sedation. It has also been known as an antiepileptic agent. But there have been several neurologic events reported, following propofol administration. This case report presents a young woman with myoclonic convulsions after a single dose of propofol.
Anahtar Kelimeler
Kaynakça
- 1. Jungheinrich C, Scharpf R, Wargenau M, Dilger C, Bepperling F. Pharmacokinetics of the generic formulation propofol 1% fresenius in comparison with the original formulation (Disoprivan 1%) Clin Drug Investig 2002; 22: 417–27.
- 2. Walder B, Tramer MR, Seeck M. Seizure-like phenomena and propofol: a systematic review. Neurology 2002; 58: 1327–32. 3. Jung SH, Kim TW, Jung KY, Kim JM. A case of propofolinduced seizure-like phenomena. Korean J Epilepsy Soc 2003; 7: 51–3.
- 4. Finley GA, MacManus B, Sampson SE, Fernandez CV, Retallick R. Delayed seizures following sedation with propofol. Can J Anaesth 1993; 40: 863–5.
- 5. Manikandan S, Sinha PK, Neema PK, Rathod RC. Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. Anesth Analg 2005; 100: 1468-9. 6. Islander G, Vinge E. Severe neuroexcitatory symptoms after anaesthesia with focus on propofol anaesthesia. Acta Anaesthesiologica Scandinavica 2000; 44: 144–9.
- 7. AstraZeneca. Issued to the medical profession only ‘Diprivan’ 1%. Insert of Diprivan P016791 2004.
- 8. Dearlove JC, Dearlove OR. Cortical reflex myoclonus after propofol anaesthesia. Anaesthesia 2002; 57: 834–5.
- 9. Borgeat A, Dessibourg C, Popovic V, Meier D, Blanchard M, Schwander D. Propofol and spontaneous movements: an EEG study. Anesthesiology 1991; 74: 24–7.
- 10. Makela JA, Livanainen M, Pieninkeroinen IP, Waltimo O, Lahdensuu M. Seizures associated with propofol anesthesia. Epilepsia 1993; 34: 832–5.
- 11. Lowson S, Gent JP, Goodchild S. Anticonvulsant properties of propofol and thiopental comparison using two tests in laboratory mice. Br J Anaesth 1990; 64: 59-63.
- 12. Stecker MM, Kramer TH, Raps EC, O’Meeghan R, Dulaney E, Skaar DJ. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia 1998; 39: 18-26.
- 13. Leikin JB, Benigno J, Dubow JS, Fisher M. Status epilepticus due to tiagabine digestion. Am J Ther 2008; 15: 290-2. 14. Borgeat A. Propofol: pro- or anticonvulsant? Eur J Anaesthesiol 1997; 14: 17-20.
- 15. Sutherland MJ, Burt P. Propofol and seizures. Anaesth Intensive Care 1994; 22: 733-7.
- 16. Bendiksen A, Larsen LM. Convulsions, ataxia, and hallucinations following propofol. Acta Anaesthesiol Scand 1998; 42: 739-41.
Toplam 13 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2012 |
| Yayımlandığı Sayı | Yıl 2012 Cilt: 17 Sayı: 2 |