Kronik Böbrek Yetmezliğinde Serum Ürik Asit Düzeyleri

Yıl 2012, Cilt: 17 Sayı: 1, 23 - 27, 01.02.2012

Emre Erdem Ayşe Özdemir Coşkun Kaya Ahmet Karataş Kuddusi Cengiz

Öz

Amaç: Kronik böbrek yetmezliğinde (KBY) serum ürik asit düzeyi artar. Biz çalışmamızda diyalize girmeyen evre 3-5 KBY hastaları ile hemodiyalize giren hastaların serum ürik asit düzeylerini inceledik. Ayrıca diyalize girmeyen evre 3-5 KBY hastalarında serum ürik asit düzeyi ile ilişki faktörleri araştırdık. Gereç ve Yöntem: Çalışmamız hemodiyalize giren 46, diyalize girmeyen evre 3-5 KBY olan 93, toplam 139 hasta ile yapıldı. Hastaların kan biyokimyasal değerlerine bakıldı. Vücut kitle indeksleri (VKİ) hesaplandı. Bulgular: Hemodiyalize giren hastaların ortalama serum ürik asit düzeyi 6,4 ±1,2 mg/dl, prediyaliz KBY olarak takip edilen hastaların ortalalama serum ürik asit düzeyi ise 7,3 ±1,9 mg/dl idi (p0.05). Serum ürik asit düzeyi yüksek olan hastalarımızın ortalama VKİ'leri ve bel çevreleri daha fazla idi (p

Anahtar Kelimeler

Kronik böbrek yetmezliği, Ürik asit, Vücut kitle indeksi

Serum Uric Acid Levels in Chronic Kidney Disease

Öz

Objective: Serum uric acid levels increase in chronic kidney disease (CKD). In our study, we examined the levels of serum uric acid levels in predialysis patients with stage 3-5 CKD and patients undergoing hemodialysis. We also searched the factors related to serum uric acid levels of predialysis patients with stage 3-5 CKD. Materials and Methods: 139 patients were included in the study; 46 patients undergoing hemodialysis and 93 patients with stage 3-5 CKD who were followed without dialysis. Serum routine biochemical parameters were studied. Body mass index (BMI) were calculated. Results: Mean serum uric acid levels were 6.4 ±1.2 mg/dl and 7.3±1.9 mg/dl in hemodialysis patients and predialysis CKD patients, respectively (p0.05). In patients with higher serum uric acid levels, mean BMI and waist circumference were higher (p

Anahtar Kelimeler

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Kaynakça

• Kutzing MK, Firestein BL. Altered uric acid levels and disease states. J Pharmacol Exp Ther 2008; 324: 1-7.
• Johnson RJ, Kang DH, Feig D, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 2003; 41: 1183-1190.
• Klemp P, Stansfield SA, Castle B, Robertson MC. Gout is on the increase in New Zealand. Ann Rheum Dis 1997; 56: 22- 26.
• Chang HY, Pan WH, Yeh WT, Tsai KS. Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993-96). J Rheumatol 2001; 28: 1640-1646.
• Shahbazian H, Zand Moghadam A, Ehsanpour A, Khazaali M. Changes in plasma concentrations of hypoxanthine and uric acid before and after hemodialysis. Iran J Kidney Dis 2009; 3: 151-155.
• Bober J, Kedzierska K, Safranow K, et al. Influence of glucose in dialyzing fluid on purine concentrations in hemodialyzed patients with chronic renal failure. Nephron Clin Pract 2003; 95: 31-36.
• Kanbay M, Yilmaz MI, Sonmez A, et al. Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease. Am J Nephrol 2011; 33: 298-304.
• Satirapoj B, Supasyndh O, Chaiprasert A, et al. Relationship between serum uric acid levels with chronic kidney disease in a Southeast Asian population. Nephrology (Carlton) 2010; 15: 253-258.
• Yoo TW, Sung KC, Shin HS, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J 2005; 69: 928-933.
• See LC, Kuo CF, Chuang FH, et al. Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. J Rheumatol 2009; 36: 1691-1698.
• Seki S, Tsutsui K, Fujii T, et al. Association of uric acid with risk factors for chronic kidney disease and metabolic syndrome in patients with essential hypertension. Clin Exp Hypertens 2010; 32: 270-277.
• Şengül E, Binnetoğlu E, Yılmaz A. Kronik Böbrek Hastala- rında Ürik Asit ve D vitamini Düzeyleri Arasındaki İlişki. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 2011; 20: 163-167.
• Kanbay M, Solak Y, Dogan E, Lanaspa MA, Covic A. Uric acid in hypertension and renal disease: the chicken or the egg? Blood Purif 2010; 30: 288-295.
• Gönderilme Tarihi: 16.08.2011