GHRELİN HORMONU VE BİYOLOJİK AKTİVİTELERİ

Yıl 2006, Cilt: 4 Sayı: 2, 62 - 68, 30.03.2006

Alpaslan Dayangaç

Öz

Ghrelin, 28 amino asitin 3. amino asitine n-oktanoik
asidin bağlanması ile meydana gelen ve ilk olarak midede keşfedilen bir peptid
olarak tanımlanmaktadır. Hormonunun ana sentez kaynağı midenin fundus
bölgesindeki nöroendokrin hücrelerdir. Ayrıca ghrelin, bağırsak, hipotalamus,
hipofiz, beynin bazı bölge-leri, kalp, karaciğer, uterus, böbrek, yağ doku,
plasental doku, immün hücreler, pankreas, prostat dokusu, tükrük ve bazı bitki
türlerinde sentezlenmektedir. Bu makale, ghrelin hormonunun tespit edilen nöro-endokrinolojik
ve fizyolojik etkileri hakkında bilgi içermektedir.

 

Anahtar Kelimeler

Ghrelin, Biyolojik Aktivite

Kaynakça

• 1. Ariyasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., Shirakami, G., Usui, T., Shimatsu, A., Doi, K., Hosoda, H., Kojima, M., Kangawa, K., Nakao, K., 2001, Stomach is a ma-jor source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans, Journal of Clinical Endocrinology & Metabolism. 86, 10, 4753-4758.
• 2. Arvat, E., Di Vito L., Broglio, F., Papotti, M., Muccioli, G., Dieguez, C., 2000, Preliminary evidence that ghrelin, the natural GH secre-tagogue (GHS)-receptor ligand, strongly stimula-tes GH secretion in humans, Journal of. Endo-crinology. Investigation 23, 493–495.
• 3. Aydın, S., Geçgil, H., Zengin, F., Özercan, H.İ., Karataş, F., Aydın, S., Balık, D.T., Ozkan, Y., Dağli, F., and Çelik, V., 2006b, Ghrelin in plants: What is the function of an appetite hormone in plants, Peptides, Article in Press.
• 4. Aydin, S., Aydın, S., Ozkan, Y., and Kumru, S., 2005b. Ghrelin is present in human colostrum, transitional and mature milk, Peptides, In Press,
• 5. Aydin, S., Halifeoglu, İ., Ozercan, İ.H., Erman, F., Kilic, N., Aydin, S., İlhan, N., İlhan, N., Oz-kan, Y., Akpolat, N., Sert, L., Caylak, E., 2005 a, A comparison of leptin and ghrelin levels in plasma and saliva of young healthy subjects, Peptides, 26, 4, 647-652.
• 6. Aydin, S., Ozercan, I.H., Aydin, S., Ozkan, Y., Dagli, F. and Oğuzoncul, F., Geçgil, H., 2006a. Biological rhythm saliva ghrelin in human, Biological Rhythm Research, 1-9.
• 7. Aydin, S., Ozercan, I.H., Dagli, F, Aydin, S., Dogru, O., Celebi, S., Akin, O. and Guzel, S.P., 2005c. Ghrelin immunohistochemistry of gast-ric adenocarcinoma and mucoepidermoid carci-noma of salivary gland, Biotchnic and Histo-chemisry, 80, (3-4), 163-168.
• 8. Bagnasco, M., Dube, M.G., Kalra, P.S., Kalra, S.P., 2002, Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy, Endocrinology 143, 4409–4421.
• 9. Banks, W.A., Tschop, M., Robinson, S.M. and Heiman, M.L., 2002, Extend and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure, Journal of Pharmacology and Experimental Therapeutics 302, 822-827.
• 10. Barreiro, M.L., Tena-Sempere, M., 2004, Ghrelin and reproduction: a novel signal linking energy status and fertility?, Molecular and Cellular Endocrinology 226, 1-2, 1-9.
• 11. Broglio, F., Koetsveld, P.P., Benso, A., Gottero, C., Prodam, F., Papotti, M., Muccioli, G., Gauna, C., Hofland, L., Deghengh,i R., Arvat, E., Lely, A.J. and Ghigo, E., 2002, Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans, Journal of Clinical Endocrinology Metabolism 87, 4829–4832.
• 12. Caminos, J.E., Seoane, L.M., Tovar, S.A., Casanueva, F.F., Dieguez, C., 2002, Influence of thyroid status and growth hormone deficiency on ghrelin, European Journal of Endocrinology 147, 159–163.
• 13. Caminos, J.E., Tena-Sempere, M., Gaytan, F., Sanchez-Criado, J.E., Barreiro, M.L., Noguei-ras, R., Casanueva, F.F., Aguilar, E., Dieguez, C., 2003, Expression of ghrelin in the cyclic and pregnant rat ovary, Endocrinology 144, 4, 1594-602.
• 14. Carling, D., 2004, AMP-activated protein kina-se: balancing the scales. Biochimie, Article in Press.
• 15. Cassoni, P., Papotti, M., Ghe, C., Catapano, F., Sapino, A., Graziani, A., 2001, Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines, The Journal of Clinical Endocrinology and Metabolism 86, 1738–1745.
• 16. Cummings, D.E., Purnell, J.Q., Frayo, R.S., Schmidova, K., Wisse, B.E., Weigle, D.S., 2001, A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans, Diabetes 50, 8, 1714-9.
• 17. Dass, N.B., Munonyara, M., Bassil A.K., Hervieu, G.J., Osbourne, S., Corcoran, S., Morgan, M., a Sanger, G.J., 2003, Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin, Neuroscience 120, 2, 443-453.
• 18. Date, Y., Kojima, M., Hosoda, H., 2000, Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesised in a distinct endocrine cell type in gastrointestinal tract of rats and humans, Endocrinolgy 141, 4255-4261.
• 19. Dayangaç, A., 2005. Ghrelinin izole sıçan miyometriyumunda spontan kasılmalara etkisi, Doktora Tezi, Fırat Üniversitesi Fen Bilimleri Enstitüsü, Elazığ.
• 20. Dornonville de la Cour, C., Lindström, E., Norlén, P., Håkanson, R., 2004, Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells, Regulatory Peptides 120, 1-3, 23-32.
• 21. Eden-Engstrom, B., Burman, P., Holdstock, C., Karlsson, F.A., 2003, Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients, Journal Clinical Endocrinology Metabolism 88, 5193–5198.
• 22. Fujino, K., Inui, A., Asakawa A., Kihara, N., Fujimura, M., Fujimiya, M., 2003, Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats, Journal of Physiology 550,. 227–240.
• 23. Furuta, M., Funabashi, T., Kimura, F., 2001, Intracerebroventricular administration of ghre-lin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats, Biochemistry Biophysiology Research Commu-nication 288, 780–785.
• 24. Gaskin, F.S., Farr, S.A., Banks, W.A., Kumar, V.B., Morley, J.E., 2003, Ghrelin-induced fee-ding is dependent on nitrik oxide, Peptides, 1-6.
• 25. Gaytan, F., Barreiro, M.L., Chopin, L.K., Herington, A.C., Morales, C. Pinilla L., Casanueva, F.F., Aguilar, E., Diéguez, C., Tena-Sempere, M., 2003, Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary, Journal of. Clinical Endocrinology & Metabolism 88, 879–887.
• 26. Guallino, O., Camines, J.E., Blancosm, M., 2001, Ghrelin, a novel plasental-derived hormone, Endocrinology 142, 778-794.
• 27. Hattari, N., Saito, T., Yagyu, T., Jiang, B.H., Kitagawa, K., İnagalvi, C., 2001, GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells and neutrophils, Journal of Clinical Endocrinolgy and Metabolism 86, 4284-4291
• 28. Howard, A., Feighner, S. and Cully, D., 1996, A receptor in pitutiary and hypothalamus that function in growth hormone release, Science, 12 , 1, 137-145.
• 29. Jeffery, P.L., Herington, A.C., Chopin, K.L., 2003, The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer, Cytokine & Growth Factor Reviews 14, 113-122.
• 30. Katugampola, S., Davenport, A., 2002, Emer-ging roles for orphan G-protein-coupled recep-tors in the cardiovascular system, Targets, 1, 6 , 206-213.
• 31. Kemigai, J., Tamura, H., Ishii, S., Sagihara, H., Oikawa, S., 2004, Effects of insulin, leptin and glukagon on ghrelin secretion from isolated perfused rat stomach, Regulatory Peptides 119, 1-2, 77-81.
• 32. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K., 1999, Ghrelin is growth-hormone-releasing acylated peptide from stomach, Nature 402, 656-660.
• 33. Koo, G.C., Huang, C., Camacho, R., Trainor, C., Blake, J.T., Sirotina-Meisher, A., 2001, Im-mune enhancing effect of a growth hormone secretagogue, Journal of Immunology 166, 4195-4201.
• 34. Korbonits, M., Goldstone, A.P., Gueorguiev, M., Grossman, A.B., 2004, Ghrelin-a hormone with multiple functions, Neuroendocrinology 25, 1, 27-68.
• 35. Lai, J.K.C., Cheng, C.H.K., Ko, W.H., Leung, P.S., 2005, Ghrelin system in pancreatic AR42J cells: its ligand stimulation evokes calcium signalling through ghrelin receptors, The International Journal of Biochemistry & Cell Biology, 37, 4, 887-900.
• 36. Masaoka, T., Suzuki, H., Hosoda, H., Ota, T., Minegishi, Y., Nagta, H., Kangawa, K., Ishii, H., 2003, Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes, FEBS Letters 541, 64-68.
• 37. Masuda, Y., Tanaka, T., Inomata, N., Tanaka, S., Itoh, Z., Hosoda, H., Kojima, M., Kangawa, K.,2000,Ghrelin stimulates gastric ascid secreti-on and motility in rats, Biochemical and Bio-physical Research Communications270,905-908.
• 38. Murakami, N., Hayashida, T., Kuroiwa, T., Nakahara, K., Ida, T., Mondal, M.S., Nakazato, M., Kojima, M., Kangawa, K., 2002, Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats, Journal of Endocrinology 174, 283–288.
• 39. Mustonen, A.M., Nieminen, P., Hyvarinen, H., 2001, Preliminary evidence that pharmacologic melatonin treatment decreases rat ghrelin levels, Endocrine 16, 43–46.
• 40. Nakahara, K., Takahiro, H., Nakazato, M., Kojima, M., Hosoda, H., Kangawa, N., Muarkami, N., 2003, Effect of chronic treatments with ghrelin on milk secretion in lactating rats, Biyochemical and Biophysical Research Communication. 303, 751-755.
• 41. Peino, R., Baldelli, R., Rodriguez-Garcia, J., Rodriguez-Segade, S., Kojima, M., Kangawa, K., Arvat, E., Ghigo, E., Dieguez, C., Casacueva, F.F., 2000, Ghrelin induced growth hormone secretion in humans, European Journal of Endocrinilogy 143, R11-R14.
• 42. Pinkney, J., Williams, G., 2002, Ghrelin gets hungry, The Lancet 359, 9315, 1360-1361.
• 43. Rudovich, N.N., Dick, D., Moehlig, M., Otto, B., Spranger, J., Rochlitz, H.J., Ristow, M., Tschoep, M., Pfeiffer, A.F.H., 2005, Ghrelin is not suppressed in hyperglycemic clamps by gastric inhibitory polypeptide and arginine. Regulatory Peptides 127, 1-3, 95-99.
• 44. Sakata, I., Nakamura, K., Yamazaki, M., Hayashi Y., Kangawa, K., 2002, Ghrelin-producing cell-exit as two of cells, closed and opened types cells, in the rat gastrointestinal tract, Peptides 23, 3, 531-536.
• 45. Shibata, K., Hosoda, H., Kojima, M., Kangawa, K., Makino, Y., Makino, I., Kawarabayashi T., Futagami, K., Gomita, Y., 2004, Regulation of ghrelin secretion during pregnancy and lactation in the rat: possible involvement of hypothalamus. Peptides 25, 2, 279-287.
• 46. Takaya, K., Ariyasu, H., Kanamoto, N., Iwakura, H., Yoshimoto A., Harada, M., 2000, Ghrelin strongly stimulates growth hormone release in humans. Journal of Clinical Endo-crinology and. Metabolism 85, 4908–4911.
• 47. Tena-Sempere, M., 2005. Exploring the role of ghrelin as novel regulator of gonodal function, Growth Hormone and IGF Research 15, 2, 83-85.
• 48. Tena-Sempere, M., Aguilar, E.; Fernandez-Fernandez, R., Pinilla, L., 2004, Ghrelin inhibits prolactin secretion in prepubertal rats, Neuroendocrinology 79, 133–141.
• 49. Tena-Sempere, M., Barreiro, M.L., Gonzalez, L.C., Gaytan, F., Zhang, F.P., Caminos, J.E., 2002, Novel expression and functional role of ghrelin in rat testis, Endocrinology 143, 717–725.
• 50. Tschop, M., Smiley, D.L, Heiman, M.L., 2000, Ghrelin induces adiposity in rodents, Nature 407, 6806,:908-913.
• 51. Ueno, H., Yamaguchi, H., Kangawa, K., Nakazato, M., 2005, Ghrelin: a gastric peptide that regulates food intake and energy homeos-tasis, Regulatory Peptides 126, 1-2, 11-19
• 52. Volante, M.,. Allia, E., Gugliotta, P., Funaro, A., Broglio, F., Deghenghi, R., 2002, Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors, The Journal of Clinical Endocrinology and Metabolism 87, 1300–1308.
• 53. Wang, G., Lee, H.M., Englander, E., Greeley, H.G., 2002, Ghrelin—not just another stomach hormone, Regulatory Peptides 105, 75–81.
• 54. Xia, Q., Pang, W., Pan, H., Zheng, Y., Kang, J.S.,. Zhu, S.G, 2004, Effects of ghrelin on the proliferation and secretion of splenic T lymphocytes in mice, Regulatory Peptides 122, 3, 173-178.