GHRELİN VE METABOLİK ETKİLERİ

Yıl 2008, Cilt: 6 Sayı: 3, 105 - 115, 31.07.2008

Dürrin Özlem Dabak Tuncay Kuloğlu

Öz

Ghrelin,
yakın zamanda keşfedilen, enerji dengesinin düzenlenmesi ve glukoz
metabolizması üzerine etkili bir hormondur.
Günümüzde, ghrelin homologlarının balıklarda, kuşlarda, birçok memelide ve
hatta bitkilerde bulunduğu belirlenmiştir. Ghrelinin insanlarda ve hayvanlarda
güçlü bir büyüme hormonu salgılatıcı aktivite-si vardır. Ghrelin, insanlarda ve
kemiricilerde esas olarak mide mukozasında
yer alan endokrin fonksiyonlara sahip sırasıyla P/D1ve X/A hücreleri tarafından
üretilmektedir. Ancak ghrelinin, hem insan hem de kemirici-lerde mide dışında birçok organda bulunduğu da
bildirilmiştir. Bu derlemede ghrelinin keşfi, doku dağılımı ve fizyolojik
etkileri üzerine yoğunlaşılmıştır.

Anahtar Kelimeler

Ghrelin, Büyüme Hormonu Salgılatıcı Reseptör, Ghrelin İmmünreaktif Hücreler

Kaynakça

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