Sık akraba evliliği yapılan bir bölgede büyük bir ekokardiyografi serisinde bikuspit aortik kapak prevalansı

Öz

Bicuspid aortic valve (BAV) is one of the most common congenital anomalies of the heart, though its definitive prevalence is not dear. We sought to determine the prevalence of BAV in a large database of echocardiographic measurements from a single institution in the area of frequent consanguineous marriage (South-east Anatolia region) and we present the frequencies of BAV-related complications such as stenosis, regurgitation, and assendan aorta dilatation. We retrospectively analyzed 31.265 echocardiograms performed at our academic institution between 2004 and 2007 for various indications. BAV is often associated with aortic stenosis, regurgitation, and ascending aorta dilatation and BAV is an independent risk factor for infective endocarditis. The prevalence of BAV was calculated, and the frequency of aortic stenosis, regurgitation, and ascending aorta dilatation among BAV cases was determined. Our database revealed a gender distribution of 11.339 males (47%) and 12.926 (53%) females.The total prevalence of BAV was 0.57% (n = 180). The rate of consanguineous marriage is 20.9% in overeall Turkey. The rate of consanguineous marriage is 40.4% in our region The gender-specific prevalence was 1.08% in males and 0.44% in females. Regurgitation was observed in 58.3% (28.9% mild, 29.4% severe) of BAV cases, stenosis in 40% (17.8% mild, 22.2% severe), and dilatation in 33.3%. The prevalence determined in our study is similar to the prevalence determined in other,recent echocardiography and autopsy studies, suggesting a lower incidence of BAV than previously thought despite high rate of consanguineous marriage. Regurgitation was the most common valvular complication in our database.

Anahtar Kelimeler

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Sık Akraba Evliliği Yapılan Bir Bölgede Büyük Bir Ekokardiyografi Serisinde Bikuspit Aortik Kapak Prevalansı

Öz

Bikuspit aort kapak (BAK) kalbin en sık korijenitai anomalilerinden olmakla beraber prevalansı tam olarak belli değildir. Akraba evliliğinin yaygın olduğu (Güneydoğu Anadolu Bölgesi) bir bölgeden tek merkeze ait, büyük bir ekokardiyografik veri tabanından,' BAK'ın'prevalansını tespit etmeyi amaçladık ve BAK ile ilişkili aort stenozu, yetersizliği ve çıkan aorta dilatasyonu gibi komlikasyonlarıri sıklığını sunduk. Üniversite hastanemizde 2004 ye 2007 yıllan arasında çeşitli endikasyonlar için yapılan ve ekokardiyografik veri tabanında'kayıtlı bulunan 31.265 raporu retrospektif olarak inceledik. BAK sıklıkla aort stenozu, yetersizliği ve çıkan aortanın genişlemesi ile birliktedir. BAK infektif endokardit için bağımsız bir risk faktörüdür. BAK'un prevelansı hesaplandı ve BAK olanlarda aort darlığı, aort yetersizliği ve çıkan aortanın genişleme sıklığı araştırıldı. Veri tabanımız cinsiyet dağılımını 11.939 erkek (%47) 12.926 kadın(%53) olarak'göstermiştir BAK prevalansı %0.57'ydi (n: 180). Tüm Türkiye de akraba evliliği oranı %20.9 dur. Bölgemizde akraba evliliği oranı %40.4. Cinsiyete özgü BAK prevalansı erkeklerde %1.08, kadınlarda %0.44'tü. BAK'lıların % 58.3'ünde aort yetersizliği (%28.9. hafif, %29.4 ileri), %40;ında aort darlığı (%17.8 hafif, %22.2 şiddetli) ve %33.3'ünde çıkan aortta genişleme gözlemlendi. Yüksek akraba evliliği oranına rağmen çalışmamızda BAK prevelansı daha önce yapılan ekokardiyografi ve otopsi çalışmaları ile benzer ve tahmin , edilenden az bulundu. Veri tabanımıza göre aort yetersizliği eri sık eşlik eden komplikasyondu.

Anahtar Kelimeler

• Ekokardiografi, Biküspit Aort Kapak

Kaynakça

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