A general overview to physiological and morphological changes and developments

Öz

Presbycusis (age-related hearing loss) is one of the principal communicative and chronic medical disorders of our aged population. Preventative and curative biomedical interventions provide us with an understanding of the basis of this neural and molecular sensory deficit. The cochlear nucleus (CN) receives the outputs of the auditory portion of the inner ear, and sends these outputs to the centres where critical sound and perception analyses are conducted in parallel processing pathways of brainstem. This location plays a key role to process the sound. This location is an important place to investigate the structural and functional changes related to aging occuring in cochlear nucleus. Our goal is to reveal the neurophysiologic bases of functional changes which occur in mammalian CN related to aging.

Anahtar Kelimeler

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Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış

Öz

Presbikuzi (yaşlanmaya bağlı olarak işitme gücünün azalması); yaşlanmış insanlarımızın başta gelen iletişimsel ve kronik tıbbi bozukluğudur. Önleyici ve iyileştirici biyomedikal girişimler sadece, bu duyu kaybının sinirsel ve moleküler temelini anlamamızı sağlar. Koklear nukleus (KN); iç kulağın, işitme duyusuna ait kısmının çıktılarını alır ve beyin sapındaki paralel işleme yollarında kritik ses analizi ve algılama yapılan merkezlere aktarır. Sesin işleme tabi tutulması için bu bölge, anahtar bir rol oynar. Bu bölge yaşlanmaya bağlı olarak KN'de meydana gelen yapısal ve fonksiyonel değişiklikleri incelemek için önemli bir yerdir. Amacımız, memeli KN'sinde yaşlanmaya bağlı olarak meydana gelen fonksiyonel değişikliklerin nörofizyolojik temellerini ortaya koymaktır.

Anahtar Kelimeler

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Kaynakça

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