Biyolojik Araştırmalarda Zebra Balığının (Danio rerio Hamilton, 1822) Kullanılması ve Önemi

Öz

Son yıllarda omurgalı model organizmalar biyolojik, genetik, farmakolojik ve toksikolojik alanda birçok araştırmada sıklıkla kullanılmaktadır. Zebra balığının (Danio rerio) gelişme biyolojisi ve insan hastalıkları konularında bilimsel popularitesi oldukça artmıştır ve bu nedenle bilimsel platformda oldukça önemli bir omurgalı model organizma haline gelmiştir. Daha da önemlisi, yapılan bazı araştırmalar zebra balığı ve insan hücre metabolizması arasındaki benzerliği göstermişlerdir. Bu derleme çalışmasında bir omurgalı model organizma olan zebra balığının biyolojik önemi ve bilimsel avantajları irdelenmeye çalışılmıştır.

Anahtar Kelimeler

• Zebra Balığı,Omurgalı model organizma,Hücre metabolizması

Kaynakça

1. Adamski, J. ve Suhre, K. 2013. Metabolomics platforms for genome wide association studies-linking the genome to the metabolome. Current Opinion in Biotechnology, 24:39-47.
2. Anastasiou, D., Poulogiannis, G., Asara, J.M., Boxer, M.B., Jiang, J.K. Shen, M. Bellinger, G., Sasaki, A.T., Locasale, J.W., Auld, D.S., Thomas, C.J., Vander Heiden, M.G. ve Cantley, L.C. 2011. Inhibition pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science, 334:1278-1283.
3. Auer, T.O., Duroure, K., De Cian, A., Concordet, J. P. ve Del Bene, F. 2014. Highly efficient CRISPR/Cas9-mediated knock in zebrafish by homology-independent DNA repair. Genome Research, 24:142-153.
4. Babin, P.J. ve Vernier, J.M. 1989. Plasma lipoproteins in fish. The Journal of Lipid Research, 30:467-489.
5. Cox, L.M. ve Blaser, M.J. 2013. Pathways in microbe-induced obesity. Cell Metabolism, 17:883-894.
6. Dumas, M.E., Kinross, J. ve Nickolson, J.K. 2014. Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology, 146:46-42.
7. Ertug, N.D., Akbulut, C., Helli, S. ve Olgun, U. 2015. Histological changes in the liver of the zebrafish (Danio rerio) after exposure to poly (2-ethyl-2-oxazoline). Elixir Biosciences, 1-3:27-33.
8. Fang, L., Choi, S.H., Baek, J.S., Liu, C., Almazan, F., Ulrich, F., Wiesner, P., Taleb, A., Deer, E., Pattison, J., Torres-Vázquez, J., Li A.C. ve Miller, Y.I. 2013. Control of angiogenesis by AIBP-mediated cholestrol efflux. Nature, 498:118-122.

9. Fiehn, O. 2002. Metabolomics. The link between genotypes and phenotypes. Plant Molecular Biology, 48:155-171.
10. Gasch, A.P., Payseur, B.A. ve Pool, J.E. 2016. The power of natural variation for model organism biology. Trends in Genetics. Cell Press, doi.org./10.1016/j.tig.2015.12.003
11. Hall C.J., Boyle, R.H., Astin, J.W., Flores, M.V., Oehlers, S.H., Sanderson, L.E., Ellett, F., Lieschke, G.J. Crosier, K.E. ve Crosier, P.S. 2013. Immuno responsive gene 1 augments bactericidal activity of macrophage lineage cells by regulating beta-oxidation dependent mitochondrial ROS production. Cell Metabolism, 18: 265-278.
12. Hauser-Davis, R.A., Silva, J.A.N., Rocha, R.C.C., Saint Pierre, T. ve Ziolli, R.L. 2016. Acute selenium selenite exposure effects on oxidative stress biomarkers and trace elements in the model organism zebrafish (Danio rerio). Journal of Trace Elements and Medicine and Biology, 33:68-72.
13. Huang, Lindgren, A., Wu, X., Liu, N.A. ve Lin, S. 2012. High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos. Cell Reproduction, 2:695-704.
14. Jang, Z.H., Chung, H.C., Ahn, Y.G., Kwon, Y.K., Kim, J.S., Ryu, do H., Kim, C.H. ve Hwang, G.S. 2012. Metabolic profilingof an alcoholic fatty liver in zebrafish. Molecular Biosystems, 8:2001-2009.
15. Kim, K.H. ve Lee, M.S. 2014. Autophagy -a key player in cellular and body metabolism. Nature Review of Endocrinology, 10:322-337.
16. Kirkwood, J.S. Lebold, K.M., Miranda,C.L., Wright, C.L., Miller, G.W., Tanguay, R.L., Barton, C.L., Traber, M.G. ve Stevens, J.F. 2012. Vitamin C deficiency activatesthe purine nucleotide cycle in zebrafish. Journal of Biological Chemistry, 287:3833-3841.
17. Kutluyer, F. ve Aksakal, E. 2013. Sucul model organizmalar ve biyoteknolojide kullanımı: Anadolu Tarım Bilimleri Dergisi, 28:101-107.
18. Malek, R.L., Sajadi, H., Abraham, J., Grundy, M.A., Gerhard, G.S. 2004. The effects of temperature reduction on gene expression reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish. Comparative Biochemistry Physiology and Toxicology &Pharmacology, 138:363-373. Meunier, R. 2012. Stages in the development of a model organism as a platform for mecanistic models in developmental biology: Zebrafishi 1970-2000. Studies in History and Philosopy of Biological and Biomedical Sciences, 43:522-531. Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M.P., Medana, C., Stainier, D.Y., Bakkers, J. ve Santoro, M.M. 2013. Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell, 152:504-518. Peterson, R.T. Shaw, S.Y., Peterson, T.A., Milan, D.J., Zhong, T.P., Schreiber, S.L., MacRae, C.A. ve Fishman, M.C. 2004. Chemical supression of a genetic mutation in a zebrafish model of aortic coarctation. Nature Biotechnology, 22:595-599. Peterson, R.T. ve Macrae, C.A. 2012. Systematic approaches to toxicology in the zebrafish. Annual Review Pharmacology and Toxicology, 52:433-453. Prosser, G.A., Larrouy-Maumus,G.S. ve Carvalho, L.P. 2014. Metabolomic strategies fort he identification of new enzyme functions and metabolomic pathways. EMBO Reports, 15:657-669.
19. Rabinowitz, J.D. ve White, E. 2010. Autophagy and metabolism. Science, 330:1344-1348.
20. Richards, J.G. 2011. Physiological, behaviorial and biochemical adaptations of internal fishes to hypoxia. Journal of Experimental Biology, 214:191-199.
21. Ridges, S., Heaton, W.L., Joshi, D., Choi, H., Eiring, A., Batchelor, L., Choudhry, P., Manos, E.J., Sofla, H., Sanati, A., Welborn, S., Agarwal, A., Spangrude, G.J., Miles, R.R., Cox, J.E., Frazer, J.K., Deininger, M., Balan, K., Sigman, M., Müschen, M., Perova, T., Johnson, R., Montpellier, B., Guidos, C.J., Jones, D.A. ve Trede, N.S. 2012. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood, 119:5621-5631.
22. Sarras, M.P., Leontovich, A.A. ve Intine, R.V. 2015. Use of zebrafish as a model to investigate the role of epigenetics in propagating the secondary complications observed in diabetes mellitus. Comparative Biochemistry and Physiology, 178:3-7.
23. Schwabe, R.F. ve Jobin, C. 2013. The microbiome and cancer. Nature Review Cancer, 13:800-812.
24. Semova, I., Carten, J.D., Stombaugh, J., Mackey, L.C., Knight, R., Farber, S.A. ve Rawls, J.F. 2012. Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish. Cell Host &Microbe, 12:277-288.
25. Shaklee, J.B., Christiansen, J.A., Sidell, B.D., Prosser, C.L. ve Whitt, G. 1977. Molecular aspect of temperature acclimation in fish. Journal of Experimental Zoology, 201:1-20.
26. Song, Z., Zhang, X., Jia, S., Yelick, P.C. ve Zhao, C. 2016. Zebrafish as a model for human ciliopathies. Journal of Genetics and Genomics, doi.org/10.1016/j.jgg.2016.02.001
27. Suhre, K. ve Gieger, C. 2012. Genetic variation in metabolic phenotypes: study designs and applications. Nature Reviews Genetics, 13:759-769.
28. Tseng, Y.C., Chen, R.D., Lucassen, M., Schmidt, M.M., Dringen, R., Abele, D. ve Hwang, P.P. 2011. Exploring uncoupling proteins and antioxidant mechanisms under acute cold exposure in brain of zebrafish. PLoS ONE6, e18180.
29. Zhang, A., Sun, H., Xu, H., Qiu, S. ve Wang, X. 2013. Cell Metabolomics. OMICS, 17:495-501.
30. Zon, L.I. ve Peterson, R.T. 2005. In vivo drug discovery in the zebrafish. Nature Reviews Drug Discovery. 4:35-44.