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Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması

Yıl 2017, Cilt: 6 Sayı: 1, 46 - 59, 17.04.2017

Köksal Pabuçcu Tuğba Demiriz Yücer

Öz

Siyanobakteriler içindeki en önemli gruplardan biri
olan Oscillatoria türleri,
yeryüzündeki farklı (deniz, tatlı, acı) su ortamlarında yaşayabilen ve ekstrem
şartlara dayanıklı türlerdir. Özellikle sığ sularda yayılış gösterirler. Bu
türler, ilaç hammaddesi olabilecek temel bileşenleri içerdikleri ve daha az
toksik oldukları için, tıbbi açıdan önem arz etmektedirler. Son yıllarda,
tıbbi açıdan bu alglere olan ilgi artmaktadır. Bu çalışmada, Oscillatoria
türlerinden elde edilen moleküllerin antibiyotik, antiviral, antikanser,
antifungal, antibakteriyal, antiinflamatuar özellikleri ve bazı farmakolojik
etkileri ortaya konulmuş; onların tıbbi özellikleri konusunda yapılan
araştırmalar tartışılmıştır.

Anahtar Kelimeler

Cyanobacteria Oscillatoria antimikrobiyal antioksidan antikanser

Kaynakça

  • Abd El-Aty, A. M., Mohamed, A. A., Samhan, F.A., 2014. ‘In vitro antioxidant and antibacterial activities of two fresh water Cyanobacterial species, Oscillatoria agardhii and Anabaena sphaerica’, Journal of Applied Pharmaceutical Science, 4 (07): 69-75.
  • Abo-State, M. A. M., Shanab, S. M. M., Hamdy E. A. Ali, H. E. A., Abdullah, M. A., 2015. ‘Screening of Antimicrobial Activity of Selected Egyptian Cyanobacterial Species’, Journal of Ecology of Health & Environment, 3 (1): 7-13.
  • Altuner, Z., Pabuçcu, K., Türkekul, İ, 2002. ‘Tohumsuz Bitkiler Sistematiği’, Altan Yayınevi, Ankara.
  • Belay, A., Ota, Y., Miyakawa, K. ve Shimamatsu, H., 1993. ‘Current knowledge on potential health benefits of Spirulina’ J. Appl. Phycol., 5, 235-241.
  • Campbell, N., A., Reece J., B., 2000. ‘Biyoloji’, Palme Yayıncılık, Ankara.
  • Carmichael, W.W., 1992. ‘Cyanobacteria secondary metabolites—the cyanotoxins’, J. Appl. Bacteriol., 72 (6): 445-459.
  • Castenholz, R. W., 2001. ‘Species usage, concept, and evolution in the cyanobacteria (blue–green algae)’, J. Phycol., 28: 737–745.
  • Demirel, Z., Uslu Hatipoğlu, S., Nalbantsoy, A., Yılmaz, F. F., Tepedelen Erbaykent, B., Gürhan-Deliloğlu, İ., Conk Dalay, M., 2012. ‘A comparative study on antioxidant and cytotoxic effects of Oscillatoria amphibia and Spirulina platensis C-phycocyanin and crude extracts’, Ege J Fish Aqua Sci 29(1): 1-7.
  • Demiriz, T., Çökmüş, C., Pabuçcu, K., 2011. ‘Antimicrobial Activity of Some Algal Species Belonging to Cyanobacteria and Chlorophyta’, Asian Journal of Chemistry, 23 (3): 1384-1386.
  • El-Sheekh, M.M., Osman, M.E.H., Dyab, M.A., Amer, M.S., 2006. ‘Production and characterization of antimicrobial active substance from the cyanobacterium Nostoc muscoru’, Enviromental Toxicology and Pharmocology, 21: 42-50.
  • Erhard, M., Döhren, H. ve Jungblut, P., 1997. ‘Rapid typing and elucidation of new secondary metabolites of intact cyanobacteria using MALDI-TOF mass spectrometry’, Nat. Biotechnol., 15 (9): 906-909.
  • Fadoul, H. E., Juntawong, N., 2004. ‘Antimicrobial Activity of Extracts from Aquatic Algae Isolated From Salt Soil and Fresh Water in Thailand’, International Journal of Research Studies in Biosciences (IJRSB), 2:149-152.
  • Gault, P., M., Marler, H., J., 2009. ‘Handbook on Cyanobacteria’, Biochemistry, Biotechnology and Applications, Nova Science Publishers, Inc. New York. Guiry, M.D, Guiry, G.M., 2016. ‘AlgaeBase’. World-wide electronic publication, National University of Ireland, Galway. http://www.algaebase.org; searched on 20 December.
  • Hossain, F. M., Ratnayake, R. R., Meerajini, K., Kumara, K. L. W., 2016. ‘Antioxidant properties in some selected cyanobacteria isolated from fresh water bodies of Sri Lanka’, Food Science & Nutrition, 4(5): 753–758.
  • Katırcıoğlu, H., Beyatlı, Y., Aslim, B., Yüksekdağ, Z. and Atıcı, T., 2006. ’Screening for Antimicrobial Agent Production of Some Microalgae in Freshwater’, The Internet Journal of Microbiology, 2.
  • Kerby, N.W., Stewart, W.D.P., 1988. ‘Biotechnology of microalgae and cyanobacteria’, Biochemistry of the Algae and Cyanobacteria, 3: 19-334.
  • Kerby, N., Rowell, P., 1992. ‘Potential and commercial applications for photosynthetic prokaryotes’, Photosynthetic prokaryotes, 93-120.
  • Krishnaraj, R. N., Babu, S. V., Ashokkumar, B., Malliga, P., Varalakshmi, P., 2012. ‘Antioxidant property of fresh and marine water cyanobacterial extracts in Swiss mice’, JBiopest, 5 (Supplementary): 250-254.
  • Koksharova and Wolk, 2002. ‘A Novel Gene that Bears a DnaJ Motif Influences Byanobacterial Cell Division’, Journal of Bacteriology 184:5524-5528.
  • Kyadari, M., Fatma, T., Velpandian, T., Bharat, N., Bano, F., 2014. ‘Antiangiogenic and antiproliferative assessment of Cyanobacteria’, Indian Journal of Experimental Biology, 52: 835-842.
  • Luo, S., Kang, H., Krunic, A., Chen, W., Yang, J., Woodard, J. L., Fuchs, J. R., Cho, S. H., Franzblau, S. G., Swanson, S. M., Orjala, J., 2015. ‘Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045’, Bioorganic & Medicinal Chemistry, 23: 3153–3162.
  • Madhumathi, V., Deepa, P., Jeyachandran, S., Manoharan, C., Vijayakumar, S., 2011. ‘Antimicrobial Activity of Cyanobacteria Isolated from Freshwater Lake’, International Journal of Microbiological Research, 2 (3): 213-216.
  • Madigan, M.T., Martinko, J.M. ve Parker, J., 2003. ‘Brock Biology of Microorganisms’, 10th ed., Prentice Hall/Pearson Education.
  • Mukund, S., Sivasubramanian, V., 2014.‘Anticancer Activity of Oscillatoria terebriformis Cyanobacteria in human lung cancer cell line A549’ International Journal of Applied Biology and Pharmaceutical Technology, 5 (2).
  • Nair, S., Bhimba, B. V., 2013. ‘Bioactive potency of Cyanobacteria Oscillatoria spp.’ International Journal of Pharmacy and Pharmaceutical Sciences, 5 (2).
  • Neilan B.A, 1995. ‘Identification and phylogenetic analysis of toxigenic cyanobacteria by multiplex randomly amplified polymorphic DNA PCR’, Applied Andenvıronmental Microbiology, 61: (6) 2286–2291.
  • Pawar, S. T., Puranik, P. R., 2008. ‘Screening of terrestrial and freshwater halotolerant cyanobacteria for antifungal activities’, World J Microbiol Biotechnol, 24:1019–1025.
  • Prabakaran, M., 2011. ‘Invitro antimicrobial potentials of marine Oscillatoria species’, Asian Journal of Plant Science and Research, 1 (3): 58-64.
  • Quinn, J., Li, H.H., Singer, J., Morimoto, B., Mets, L., Kindle, K., Merchant, S., 1993. ‘The plastocyanin-deficient phenotype of Chlamydomonas reinhardtii Ac-208 results from a frame-shift mutation in the nuclear gene encoding preapoplastocyanin’, J. Biol. Chem., 268: 7832-7841.
  • Rasha K. Osman, R. K., Goda, H. A., Higazy, A. M., 2015. ‘Evaluation of Some Extra-and Intracellular Cyanobacterial Extracts as Antimicrobial Agents’, International Journal of Advanced Research, 3 (5): 852-864.
  • Rippka, R., Deruelles, J., Waterbury, J.B., Herdman, M. and Stanier, R.Y., 1979. ‘Generic assignments, strain histories and properties of pure cultures of cyanobacteria’, J. Gen. Microb., 111: 1-61.
  • Sethubathi, G. V. B. and Prabu, V. A., 2010. ‘Antibacterial Activity of Cyanobacterial Species from Adirampattinam Coast, Southeast Coast of Palk Bay’, Current Research Journal of Biological Sciences, 2(1): 24-26.
  • Shanab, S.M.M, Mostafa, S.S.M., Shalaby, E.A., Mahmoud, G.I.,2012. ‘Aqueous extracts of microalgae exhibit antioxidant and anticancer activities’, Asian Pacific Journal of Tropical Biomedicine, 608-615.
  • Thajuddin, N. ve Subramanian, G., 2005. ‘Cyanobacterial biodiversity and potential applications in biotechnology’, Curr. Sci., 89(1): 47-57.
  • Thangam, R., V. Suresh, V., Princy, W. A., Rajkumar, M., SenthilKumar, N., Gunasekaran, P., Rengasamy, R., Anbazhagan. C., Kaveri, K., Kannan, S., 2013. ‘C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest’, Food Chemistry 140 :262–272.
  • Tong, J., Trapido-Rosenthal, H., Wang, J., Wang, Y., Li, Q. X., Lu, Y., 2012. ‘Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters’, Marine Drugs, 10: 521-538.
  • Whitton, A. ve Potts, M., 2000. ‘The Ecology of Cyanobacteria’, Kluwer Academic Publishers, Netherlands.

Yıl 2017, Cilt: 6 Sayı: 1, 46 - 59, 17.04.2017

Köksal Pabuçcu Tuğba Demiriz Yücer

Öz

Kaynakça

  • Abd El-Aty, A. M., Mohamed, A. A., Samhan, F.A., 2014. ‘In vitro antioxidant and antibacterial activities of two fresh water Cyanobacterial species, Oscillatoria agardhii and Anabaena sphaerica’, Journal of Applied Pharmaceutical Science, 4 (07): 69-75.
  • Abo-State, M. A. M., Shanab, S. M. M., Hamdy E. A. Ali, H. E. A., Abdullah, M. A., 2015. ‘Screening of Antimicrobial Activity of Selected Egyptian Cyanobacterial Species’, Journal of Ecology of Health & Environment, 3 (1): 7-13.
  • Altuner, Z., Pabuçcu, K., Türkekul, İ, 2002. ‘Tohumsuz Bitkiler Sistematiği’, Altan Yayınevi, Ankara.
  • Belay, A., Ota, Y., Miyakawa, K. ve Shimamatsu, H., 1993. ‘Current knowledge on potential health benefits of Spirulina’ J. Appl. Phycol., 5, 235-241.
  • Campbell, N., A., Reece J., B., 2000. ‘Biyoloji’, Palme Yayıncılık, Ankara.
  • Carmichael, W.W., 1992. ‘Cyanobacteria secondary metabolites—the cyanotoxins’, J. Appl. Bacteriol., 72 (6): 445-459.
  • Castenholz, R. W., 2001. ‘Species usage, concept, and evolution in the cyanobacteria (blue–green algae)’, J. Phycol., 28: 737–745.
  • Demirel, Z., Uslu Hatipoğlu, S., Nalbantsoy, A., Yılmaz, F. F., Tepedelen Erbaykent, B., Gürhan-Deliloğlu, İ., Conk Dalay, M., 2012. ‘A comparative study on antioxidant and cytotoxic effects of Oscillatoria amphibia and Spirulina platensis C-phycocyanin and crude extracts’, Ege J Fish Aqua Sci 29(1): 1-7.
  • Demiriz, T., Çökmüş, C., Pabuçcu, K., 2011. ‘Antimicrobial Activity of Some Algal Species Belonging to Cyanobacteria and Chlorophyta’, Asian Journal of Chemistry, 23 (3): 1384-1386.
  • El-Sheekh, M.M., Osman, M.E.H., Dyab, M.A., Amer, M.S., 2006. ‘Production and characterization of antimicrobial active substance from the cyanobacterium Nostoc muscoru’, Enviromental Toxicology and Pharmocology, 21: 42-50.
  • Erhard, M., Döhren, H. ve Jungblut, P., 1997. ‘Rapid typing and elucidation of new secondary metabolites of intact cyanobacteria using MALDI-TOF mass spectrometry’, Nat. Biotechnol., 15 (9): 906-909.
  • Fadoul, H. E., Juntawong, N., 2004. ‘Antimicrobial Activity of Extracts from Aquatic Algae Isolated From Salt Soil and Fresh Water in Thailand’, International Journal of Research Studies in Biosciences (IJRSB), 2:149-152.
  • Gault, P., M., Marler, H., J., 2009. ‘Handbook on Cyanobacteria’, Biochemistry, Biotechnology and Applications, Nova Science Publishers, Inc. New York. Guiry, M.D, Guiry, G.M., 2016. ‘AlgaeBase’. World-wide electronic publication, National University of Ireland, Galway. http://www.algaebase.org; searched on 20 December.
  • Hossain, F. M., Ratnayake, R. R., Meerajini, K., Kumara, K. L. W., 2016. ‘Antioxidant properties in some selected cyanobacteria isolated from fresh water bodies of Sri Lanka’, Food Science & Nutrition, 4(5): 753–758.
  • Katırcıoğlu, H., Beyatlı, Y., Aslim, B., Yüksekdağ, Z. and Atıcı, T., 2006. ’Screening for Antimicrobial Agent Production of Some Microalgae in Freshwater’, The Internet Journal of Microbiology, 2.
  • Kerby, N.W., Stewart, W.D.P., 1988. ‘Biotechnology of microalgae and cyanobacteria’, Biochemistry of the Algae and Cyanobacteria, 3: 19-334.
  • Kerby, N., Rowell, P., 1992. ‘Potential and commercial applications for photosynthetic prokaryotes’, Photosynthetic prokaryotes, 93-120.
  • Krishnaraj, R. N., Babu, S. V., Ashokkumar, B., Malliga, P., Varalakshmi, P., 2012. ‘Antioxidant property of fresh and marine water cyanobacterial extracts in Swiss mice’, JBiopest, 5 (Supplementary): 250-254.
  • Koksharova and Wolk, 2002. ‘A Novel Gene that Bears a DnaJ Motif Influences Byanobacterial Cell Division’, Journal of Bacteriology 184:5524-5528.
  • Kyadari, M., Fatma, T., Velpandian, T., Bharat, N., Bano, F., 2014. ‘Antiangiogenic and antiproliferative assessment of Cyanobacteria’, Indian Journal of Experimental Biology, 52: 835-842.
  • Luo, S., Kang, H., Krunic, A., Chen, W., Yang, J., Woodard, J. L., Fuchs, J. R., Cho, S. H., Franzblau, S. G., Swanson, S. M., Orjala, J., 2015. ‘Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045’, Bioorganic & Medicinal Chemistry, 23: 3153–3162.
  • Madhumathi, V., Deepa, P., Jeyachandran, S., Manoharan, C., Vijayakumar, S., 2011. ‘Antimicrobial Activity of Cyanobacteria Isolated from Freshwater Lake’, International Journal of Microbiological Research, 2 (3): 213-216.
  • Madigan, M.T., Martinko, J.M. ve Parker, J., 2003. ‘Brock Biology of Microorganisms’, 10th ed., Prentice Hall/Pearson Education.
  • Mukund, S., Sivasubramanian, V., 2014.‘Anticancer Activity of Oscillatoria terebriformis Cyanobacteria in human lung cancer cell line A549’ International Journal of Applied Biology and Pharmaceutical Technology, 5 (2).
  • Nair, S., Bhimba, B. V., 2013. ‘Bioactive potency of Cyanobacteria Oscillatoria spp.’ International Journal of Pharmacy and Pharmaceutical Sciences, 5 (2).
  • Neilan B.A, 1995. ‘Identification and phylogenetic analysis of toxigenic cyanobacteria by multiplex randomly amplified polymorphic DNA PCR’, Applied Andenvıronmental Microbiology, 61: (6) 2286–2291.
  • Pawar, S. T., Puranik, P. R., 2008. ‘Screening of terrestrial and freshwater halotolerant cyanobacteria for antifungal activities’, World J Microbiol Biotechnol, 24:1019–1025.
  • Prabakaran, M., 2011. ‘Invitro antimicrobial potentials of marine Oscillatoria species’, Asian Journal of Plant Science and Research, 1 (3): 58-64.
  • Quinn, J., Li, H.H., Singer, J., Morimoto, B., Mets, L., Kindle, K., Merchant, S., 1993. ‘The plastocyanin-deficient phenotype of Chlamydomonas reinhardtii Ac-208 results from a frame-shift mutation in the nuclear gene encoding preapoplastocyanin’, J. Biol. Chem., 268: 7832-7841.
  • Rasha K. Osman, R. K., Goda, H. A., Higazy, A. M., 2015. ‘Evaluation of Some Extra-and Intracellular Cyanobacterial Extracts as Antimicrobial Agents’, International Journal of Advanced Research, 3 (5): 852-864.
  • Rippka, R., Deruelles, J., Waterbury, J.B., Herdman, M. and Stanier, R.Y., 1979. ‘Generic assignments, strain histories and properties of pure cultures of cyanobacteria’, J. Gen. Microb., 111: 1-61.
  • Sethubathi, G. V. B. and Prabu, V. A., 2010. ‘Antibacterial Activity of Cyanobacterial Species from Adirampattinam Coast, Southeast Coast of Palk Bay’, Current Research Journal of Biological Sciences, 2(1): 24-26.
  • Shanab, S.M.M, Mostafa, S.S.M., Shalaby, E.A., Mahmoud, G.I.,2012. ‘Aqueous extracts of microalgae exhibit antioxidant and anticancer activities’, Asian Pacific Journal of Tropical Biomedicine, 608-615.
  • Thajuddin, N. ve Subramanian, G., 2005. ‘Cyanobacterial biodiversity and potential applications in biotechnology’, Curr. Sci., 89(1): 47-57.
  • Thangam, R., V. Suresh, V., Princy, W. A., Rajkumar, M., SenthilKumar, N., Gunasekaran, P., Rengasamy, R., Anbazhagan. C., Kaveri, K., Kannan, S., 2013. ‘C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest’, Food Chemistry 140 :262–272.
  • Tong, J., Trapido-Rosenthal, H., Wang, J., Wang, Y., Li, Q. X., Lu, Y., 2012. ‘Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters’, Marine Drugs, 10: 521-538.
  • Whitton, A. ve Potts, M., 2000. ‘The Ecology of Cyanobacteria’, Kluwer Academic Publishers, Netherlands.
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Konular Mühendislik
Bölüm Derleme Makaleler
Yazarlar

Köksal Pabuçcu Bu kişi benim

Tuğba Demiriz Yücer

Yayımlanma Tarihi 17 Nisan 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 6 Sayı: 1

Kaynak Göster

APA Pabuçcu, K., & Demiriz Yücer, T. (2017). Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması. Gaziosmanpaşa Bilimsel Araştırma Dergisi, 6(1), 46-59.
AMA Pabuçcu K, Demiriz Yücer T. Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması. GBAD. Nisan 2017;6(1):46-59.
Chicago Pabuçcu, Köksal, ve Tuğba Demiriz Yücer. “Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması”. Gaziosmanpaşa Bilimsel Araştırma Dergisi 6, sy. 1 (Nisan 2017): 46-59.
EndNote Pabuçcu K, Demiriz Yücer T (01 Nisan 2017) Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması. Gaziosmanpaşa Bilimsel Araştırma Dergisi 6 1 46–59.
IEEE K. Pabuçcu ve T. Demiriz Yücer, “Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması”, GBAD, c. 6, sy. 1, ss. 46–59, 2017.
ISNAD Pabuçcu, Köksal - Demiriz Yücer, Tuğba. “Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması”. Gaziosmanpaşa Bilimsel Araştırma Dergisi 6/1 (Nisan 2017), 46-59.
JAMA Pabuçcu K, Demiriz Yücer T. Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması. GBAD. 2017;6:46–59.
MLA Pabuçcu, Köksal ve Tuğba Demiriz Yücer. “Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması”. Gaziosmanpaşa Bilimsel Araştırma Dergisi, c. 6, sy. 1, 2017, ss. 46-59.
Vancouver Pabuçcu K, Demiriz Yücer T. Oscillatoria Türlerinin Tıbbi Özelliklerinin Araştırılması. GBAD. 2017;6(1):46-59.