Deride antioksidan mekanizmalar

Aysun Şikar Aktürk

Deride antioksidan mekanizmalar

Öz

Vücudumuzun en dış bölgesi olan derimiz ultraviyole (UV) radyasyon başta olmak üzere sürekli çevresel ajanlara maruz kalmaktadır. Bu durum deride aşırı miktarda serbest oksijen radikallerinin üretilmesine ve oksidatif strese neden olur. Oksidatif stres deride lipitler, DNA ve proteinler gibi hücresel komponentlerde hasara yol açar. Deride serbest oksijen radikallerinin zararlı etkilerini ortadan kaldırmak için enzimatik (glutation peroksidaz, katalaz, süperoksit dismutaz) ve nonenzimatik ( glutation, vitamin E, vitamin C, karotenoidler, flavonoidler ve diğerleri) antioksitatif savunma mekanizmaları mevcuttur. Bu derlemede bu mekanizmalar ayrıntılı olarak değerlendirilmiştir.

Anahtar kelimeler: Deri, serbest oksijen radikalleri, oksidatif stres, antioksidanlar

Kaynakça

Kaynaklar:
Podda M, Grundrnann-Kollmann M. Low molecular weight antioxidants and their role in skin ageing. Clin Exper Dermatol 2001; 26: 578-582.
Valko M, Rhodes CJ, Moncol J, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160: 1-40.
Wölfle U, Seelinger G, Bauer G, et al. Reactive molecule species and antioxidative mechanisms in normal skin and skin aging. Skin Pharmacol Physiol 2014; 27: 316-332.
Granot E, Kohen R. Oxidative stress in childhood-in health and disease states. Clin Nutr 2004; 23: 3-11.
Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new. J Eur Acad Dermatol Venereol 2003; 17: 663-669.
Tsai FJ, Wang YD, Chen CC, et al. Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum. J Photochem Photobiol 2012; 112: 7-15.
Lephart ED. Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms. Age Res Rev 2016; 31: 36-54.

Cals-Grierson MM, Ormerod AD. Nitric oxide function in the skin. Nitric Oxide 2004; 10: 179-193.
Xiao L, Miwa N. The lipophilic vitamin C derivate, 6-O-Palmitoylascorbate protects human keratinocytes and 3D-human skin equivalents against X-ray–induced oxidative stress and apoptosis more markedly than L-Ascorbic acid. J Cell Biol 2016; 9999: 1-12.
Fusco D, Collaca G, Cesari M. Effects of antioxidant supplementation on the aging process. Clin Interv Aging 2007; 2: 377-387.
Yamamato Y. Role of active oxygen species and antioxidants in photoaging. J Dermatol Sci 2001; 27: 1-4
Emri G, Horkay I, Remenyik E. The role of free radicals in the UV-induced skin damage. Photo-aging. Orv Hetil 2006; 23: 731-735.
Yaar M, Gilchrest BA. Photoageing: mechanism, prevention and therapy. Br J Dermatol 2007; 157: 874-887.
Biesalski HK, Obermueller-Jevic UC. UV light, beta-carotene and human skin-benefical and potentially harmfull effects. ARCH Biochem Biophys 2001; 389: 1-6.
Ichihashi M, Ahmed NU, Budiyanto A, et al. Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice. J Dermatol Sci 2000; 23: 45-50.
Shin J, Kim YJ, Kwon O, et al. Associations among plasma vitamin C, epidermal ceramide and clinical severity of atopic dermatitis. Nutr Res Pract 2016; 10: 398-403.
Şikar Aktürk A, Özdoğan HK, Bayramgürler D, et al. Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients. J Eur Acad Dermatol Venereol 2011; 26: 833-837.
Yıldırım M, Inaloz HS, Baysal V, Delibaş N. The role of oxidants and antioxidants in psoriasis. J Eur Acad Dermatol Venereol 2003; 17: 34-36.
Stephens TJ, Sigler ML, Hino PD, et al. A Randomized, double-blind, placebo-controlled clinical trial evaluating an oral anti-aging skin care supplement for treating photodamaged skin. J Clin Aesthet Dermatol 2016; 9: 25-32.
Keen MA, Hassan I. Vitamin E in dermatology. Indian Dermatol Online J 2016; 7: 311-315.
Saral Y, Uyar B, Ayar A, Naziroğlu M. Protective effects of topical alpha-tocopherol acetate on UVB irradiation in guinea pigs: importance of free radicals. Physiol Res 2002; 51: 285-290.
Stahl W, Heinrich U, Aust O, et al. Lycopene–rich products and dietary photoprotection. Photochem Photobiol Sci 2006; 5: 238-242.
Grether-Beck S, Marini A, Jaenicke T, et al. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, cross-over study. Br J dermatol 2016; Sep 23. doi: 10.1111/bjd.15080.
Janjua R, Munoz C, Gorell E, et al. A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin. Dermatol Surg 2009; 35: 1057-1065.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Aysun Şikar Aktürk

Yayımlanma Tarihi

4 Mayıs 2017

Gönderilme Tarihi

23 Kasım 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2017 Cilt: 2 Sayı: 1

IZ

https://izlik.org/JA27LR83UN

Kaynak Göster

RIS / Bibtex

APA

Şikar Aktürk, A. (2017). Deride antioksidan mekanizmalar. Güncel Dermatoloji Dergisi, 2(1), 7-13. https://izlik.org/JA27LR83UN

AMA

1.Şikar Aktürk A. Deride antioksidan mekanizmalar. GDD. 2017;2(1):7-13. https://izlik.org/JA27LR83UN

Chicago

Şikar Aktürk, Aysun. 2017. “Deride antioksidan mekanizmalar”. Güncel Dermatoloji Dergisi 2 (1): 7-13. https://izlik.org/JA27LR83UN.

EndNote

Şikar Aktürk A (01 Mayıs 2017) Deride antioksidan mekanizmalar. Güncel Dermatoloji Dergisi 2 1 7–13.

IEEE

[1]A. Şikar Aktürk, “Deride antioksidan mekanizmalar”, GDD, c. 2, sy 1, ss. 7–13, May. 2017, [çevrimiçi]. Erişim adresi: https://izlik.org/JA27LR83UN

ISNAD

Şikar Aktürk, Aysun. “Deride antioksidan mekanizmalar”. Güncel Dermatoloji Dergisi 2/1 (01 Mayıs 2017): 7-13. https://izlik.org/JA27LR83UN.

JAMA

1.Şikar Aktürk A. Deride antioksidan mekanizmalar. GDD. 2017;2:7–13.

MLA

Şikar Aktürk, Aysun. “Deride antioksidan mekanizmalar”. Güncel Dermatoloji Dergisi, c. 2, sy 1, Mayıs 2017, ss. 7-13, https://izlik.org/JA27LR83UN.

Vancouver

1.Aysun Şikar Aktürk. Deride antioksidan mekanizmalar. GDD [Internet]. 01 Mayıs 2017;2(1):7-13. Erişim adresi: https://izlik.org/JA27LR83UN