Deride antioksidan mekanizmalar

Yıl 2017, Cilt: 2 Sayı: 1, 7 - 13, 04.05.2017

Aysun Şikar Aktürk

Öz

Vücudumuzun en dış bölgesi olan derimiz ultraviyole (UV) radyasyon başta olmak üzere sürekli çevresel ajanlara maruz kalmaktadır. Bu durum deride aşırı miktarda serbest oksijen radikallerinin üretilmesine ve oksidatif strese neden olur. Oksidatif stres deride lipitler, DNA ve proteinler gibi hücresel komponentlerde hasara yol açar. Deride serbest oksijen radikallerinin zararlı etkilerini ortadan kaldırmak için enzimatik (glutation peroksidaz, katalaz, süperoksit dismutaz) ve nonenzimatik ( glutation, vitamin E, vitamin C, karotenoidler, flavonoidler ve diğerleri) antioksitatif savunma mekanizmaları mevcuttur. Bu derlemede bu mekanizmalar ayrıntılı olarak değerlendirilmiştir.

Anahtar kelimeler: Deri, serbest oksijen radikalleri,  oksidatif stres, antioksidanlar

Kaynakça

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