NANOTEKNOLOJİNİN DERMATOLOJİ ALANINDA KULLANIMI

Yıl 2018, Cilt: 3 Sayı: 2, 44 - 55, 09.10.2018

Sibel Berksoy Hayta , Melih Akyol

Öz

Nanobilim,
büyüklüğü nanometre cinsinden ölçülen atomik veya moleküler ölçekte
parçacıklarla ilgilenen alan olarak tanımlanabilir. Nanoteknoloji, nano ölçekli
(1-100 nm) parçacıkların kullanımını içeren yeni bir mühendislik dalıdır.
Nanoteknoloji alanındaki bu yeni kavramın, tanı, tedavi ve önleyici uygulamalar
için dermatoloji alanında uygulanması Nanodermatolojidir. Nanoteknoloji, her
biri farklı fiziko-kimyasal özelliklere sahip nano parçacıklarla çeşitli cilt
hastalıklarının tedavisini değiştirecektir. Bu makalede, nanoteknolojinin
temellerini açıklığa kavuşturmaya ve genel olarak tıp gibi dermatolojideki yeni
gelişmelere katkılarını göstermeye çalışacağız. nanoteknoloji dermatoloji için
çok önemli bir alan olduğu unutulmamalıdır. Nanoteknoloji dermatoloji için açık
bir gelecektir.

Anahtar Kelimeler

Dermatoloji, nanoteknoloji

Kaynakça

• KAYNAKLAR:1- Tasleem A, Nuzhatun N, Syed SA, Sheikh S, Raheel M, Muzafar RS. Therapeutic and diagnostic applications of nanotechnology in dermatology and cosmetics. J Nanomedine Biotherapeutic Discov 2015: 5; 1. 2- DeLouise LA. Applications of nanotechnology in dermatology. Journal of Investigative Dermatology 2012:132;964–75.3- Lee P, Nasir A, Wong KKY. Emerging nanomedicine for skin cancer. In: Nasir A, Friedman A, Wang S, editors. Nanotechnology in Dermatology, Springer, London, 2013:119-25.4- Tasleem A, Mohammad A. Nanotechnology-dermatological perspective. Int J Nanomed Nanosurg 2016:2(2): doi http://dx.doi.org/10.16966/24703206.112.5- Antonio JR, Antonio CR, Cardeal ILS, Ballavenuto JMA, Oliveira JR. Nanotechnology in dermatology. An Bras Dermatol. 2014;89(1):126-36.6- Nasir A. Nanotechnology and dermatology: Part I-potential of nanotechnology Clinics in Dermatology 2010:28;458–66.7- Schairer D, Chouake J, Nasir A, Friedman A. Nanotechnology applications in dermatology. In: Brenner S, editor. The clinical nanomedicine handbook, Taylor & Francis Group, USA, 2014:85-194.8- Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J. 2005;19(3):311-309- Huang X, Peng X, Wang Y, Wang Y, Shin DM, El-Sayed MA, Nie S. A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. ACS Nano. 2010;4(10):5887-96.10- Huang HC, Barua S, Sharma G, Dey SK, Rege K Inorganic nanoparticles for cancer imaging and therapy. J Control Release. 2011;155(3):344-57.11- Ilbasmiş-Tamer S, Yilmaz S, Banoğlu E, Değim IT. Carbon nanotubes to deliver drug molecules. J Biomed Nanotechnol 2010;6(1):20-7.12- Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 2001;14:101-14.13- Zhang LW, Monteiro-Riviere NA. Mechanisms of quantum dot nanoparticle cellular uptake.Toxicol Sci 2009;110(1):138-55.14- Cevc G and Vierl U. Nanotechnology and the transdermal route: a state of the art review and critical appraisal. J Control Release 2010; 141: 277–99.15- Farokhzad OC. Nanotechnology for drug delivery: the perfect partnership. Expert Opin Drug Deliv 2008; 5: 927–9.16- Tran MA, Watts RJ, Robertson GP. Use of liposomes as drug delivery vehicles for treatment of melanoma. Pigment Cell Melanoma Res 2009;22:388-99.17- Nasrollahi SA, Hassanzade H, Moradi A, Sabouri M, Samadi A, Kashani MN, Firooz A. Safety assessment of tretinoin loaded nano emulsion and nanostructured lipid carriers: A Non-invasive trial on human volunteers. Curr Drug Deliv 2017;14(4):575-80.18- Hardas B, Brin MF. Topical botulinum toxin type A. Botulinum Toxin E-Book: Procedures in Cosmetic Dermatology Series 2017: 81. 19- Mihranyan A, Ferraz N, Straomme M. Current status and future prospects of nanotechnology in cosmetics. Progress in Materials Science 2012;57(5):875-910. 20- Hamishehkar H, Ghanbarzadeh S, Sepehran S, Javadzadeh Y, Adib ZM, Kouhsoltani M. Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: Potential tool for the treatment of androgenic alopecia. Drug Dev Ind Pharm 2016;42(6):846-53.21- Wu MS, Sun DS, Lin YC, Cheng CL, Hung SC, Chen PK, Yang JH, Chang HH. Nanodiamonds protect skin from ultraviolet B-induced damage in mice. J Nanobiotechnology 2015:7;13:35. 22- Chirico F, Fumelli C, Marconi A, Tinari A, Straface E, Malorni W, Pellicciari R, Pincelli C. Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway. Exp Dermatol 2007;16(5):429-36. 23- Fumelli C, Marconi A, Salvioli S, Straface E, Malorni W, Offidani AM, Pellicciari R, Schettini G, Giannetti A, Monti D, Franceschi C, Pincelli C. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol 2000;115:835-41.24- Castro GA, Ferreira LA. Novel vesicular and particulate drug delivery systems for topical treatment of acne. Expert Opin Drug Deliv 2008;5(6):665-79. 25- Qin M, Landriscina A, Rosen JM, Wei G, Kao S, Olcott W, Agak GW, Paz KB, Bonventre J, Clendaniel A, Harper S, Adler BL, Krausz AE, Friedman JM, Nosanchuk JD, Kim J, Friedman AJ. Nitric oxide-releasing nanoparticles prevent propionibacterium acnes-induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response. J Invest Dermatol 2015;135(11):2723-31.26- Kelidari HR, Saeedi M, Hajheydari Z, Akbari J, Morteza-Semnani K, Akhtari J, Valizadeh H, Asare-Addo K, Nokhodchi A. Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. Colloids Surf B Biointerfaces 2016;146:47-53.27- Inui S, Aoshima H, Ito M, Kobuko K, Itami S. Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: potential as a therapeutic reagent for acne. J Cosmet Sci 2012;63(4):259-65.28- Inui S, Aoshima H, Nishiyama A, Itami S. Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine 2011;7(2):238-41.29- Papakostas D, Rancan F, Sterry W, Blume-Peytavi U, Vogt A. Nanoparticles in dermatology. Arch Dermatol Res 2011;303:533-50. 30- Sazgarnia A, Taheri AR, Soudmand S, Parizi AJ, Rajabi O, Darbandi MS. Antiparasitic effects of gold nanoparticles with microwave radiation on promastigots and amastigotes of Leishmania major. Int J Hyperthermia 2013;29(1):79-86. 31- Ramezani F, Jebali A, Kazemi B. A green approach for synthesis of gold and silver nanoparticles by Leishmania sp. Appl Biochem Biotechnol 2012;168(6):1549-55. 32- Mayelifar K, Taheri AR, Rajabi O, Sazgarnia A. Ultraviolet B efficacy in improving antileishmanial effects of silver nanoparticles. Iran J Basic Med Sci 2015;18(7):677-83.33- Beheshti N, Soflaei S, Shakibaie M, Yazdi MH, Ghaffarifar F, Dalimi A, Shahverdi AR. Efficacy of biogenic selenium nanoparticles against Leishmania major: in vitro and in vivo studies. J Trace Elem Med Biol 2013;27(3):203-7. 34- Nadhman A, Khan MI, Nazir S, Khan M, Shahnaz G, Raza A, Shams DF, Yasinzai M. Annihilation of Leishmania by daylight responsive ZnO nanoparticles: a temporal relationship of reactive oxygen species-induced lipid and protein oxidation. Int J Nanomedicine 2016;11:2451-61. 35- Özpınar N. BALB/c farelerde oluşturulan kutanöz leyişmanyozisin tedavisi üzerine makrofaj spesifik antikor bağlı grafen oksit nanopartikülleri ile fototermal uygulamanın etkisi. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü, Parazitoloji AD. Yayımlanmamış doktora tezi. Sivas 2017.36- Soliman GM. Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges. Int J Pharm 2017;523(1):15-32. 37- Tawfik AA, Noaman I, El-Elsayyad H, El-Mashad N, Soliman M. A study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and gold nanoparticle. Photodiagnosis Photodyn Ther 2016;15:59-69. 38- Amin ME, Azab MM, Hanora AM, Abdalla S. Antifungal activity of silver nanoparticles on Fluconazole resistant Dermatophytes identified by (GACA)4 and isolated from primary school children suffering from Tinea Capitis in Ismailia - Egypt. Cell Mol Biol (Noisy-le-grand) 2017;63(11):63-7. 39- Mordorski B, Costa-Orlandi CB, Baltazar LM, Carreño LJ, Landriscina A, Rosen J, Navati M, Mendes-Giannini MJS, Friedman JM, Nosanchuk JD, Friedman AJ. Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis. Nanomedicine 2017;13(7):2267-70. 40- Costa-Orlandi CB, Mordorski B, Baltazar LM, Mendes-Giannini MJS, Friedman JM, Nosanchuk JD, Friedman AJ. Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments. J Drugs Dermatol 2018;17(7):717-20.41- Pinto MF, Moura CC, Nunes C, Segundo MA, Costa Lima SA, Reis S. A new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriers. Int J Pharm 2014;477:519-26.42- Bessar H, Venditti I, Benassi L, Vaschieri C, Azzoni P, Pellacani G, Magnoni C, Botti E, Casagrande V, Federici M, Costanzo A, Fontana L, Testa G, Mostafa FF, Ibrahim SA, Russo MV, Fratoddi I. Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis. Colloids Surf B Biointerfaces 2016;141:141-7.43- Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, Mundhenk L. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis. Nanomedicine 2017;13(1):317-27.44-Yu K, Wang Y, Wan T, Zhai Y, Cao S, Ruan W, Wu C, Xu Y. Tacrolimus nanoparticles based on chitosan combined with nicotinamide: enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose. Int J Nanomedicine 2017;13:129-42. 45- Tsuji G, Hashimoto-Hachiya A, Takemura M, Kanemaru T, Ichihashi M, Furue M. Palladium and Platinum nanoparticles activate AHR and NRF2 in human keratinocytes-implications in vitiligo therapy. J Invest Dermatol 2017;137(7):1582-6. 46- Xie Z, Paras CB, Weng H, Punnakitikashem P, Su LC, Vu K, Tang L, Yang J, Nguyen KT. Dual growth factor releasing multi-functional nanofibers for wound healing. Acta Biomater 2013;9(12):9351-9. 47- Izumi R, Komada S, Ochi K, Karasawa L, Osaki T, Murahata Y, Tsuka T, Imagawa T, Itoh N, Okamoto Y, Izawa H, Morimoto M, Saimoto H, Azuma K, Ifuku S. Favorable effects of superficially deacetylated chitin nanofibrils on the wound healing process. Carbohydr Polym 2015;123:461-7. 48- Mezzana P. Clinical efficacy of a new chitin nanofibrils-based gel in wound healing. Acta Chir Plast 2008;50(3):81-4.49- Makdisi J, Kutner A, Friedman A. The role of RNA interference in dermatology: current perspectives and future directions. J Drugs Dermatol 2012;11(11):1373-7.50- Rabbani PS, Zhou A, Borab ZM, Frezzo JA, Srivastava N, More HT, Rifkin WJ, David JA, Berens SJ, Chen R, Hameedi S, Junejo MH, Kim C, Sartor RA, Liu CF, Saadeh PB, Montclare JK, Ceradini DJ. Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials 2017;132:1-15. 51- Smith SD, Dodds A, Dixit S, Cooper A. Role of nanocrystalline silver dressings in the management of toxic epidermal necrolysis (TEN) and TEN/Stevens-Johnson syndrome overlap. Australas J Dermatol 2015;56(4):298-302.52- Jung S, Patzelt A, Otberg N, Thiede G, Sterry W, Lademann J. Strategy of topical vaccination with nanoparticles. J Biomed Opt 2009;14(2):021001. doi: 10.1117/1.3080714.53- Hia J, Nasir A. Photonanodermatology: the interface of photobiology, dermatology and nanotechnology. Photodermatol Photoimmunol Photomed 2011;27(1):2-954- Kim JK, Nasir A, Nelson KC. Nanotchnology and the diagnosis of cutaneous malignencies. In: Nasir A, Friedman A, Wang S, editors. Nanotechnology in Dermatology, Springer, London, 2013:127-32.55- Blecher Paz K, Friedman A. Nanotechnology and the diagnosis of dermatological infectious disease. J Drugs Dermatol 2012;11(7):846-51.56- Eden JG, Park S-J, Ostrom NP, Chen K-F. Recent advances in microcavity plasma devices and arrays: a versatile photonic platform J Phys D Appl Phys 2005;38:1644-8.57- Zuo L, Wei W, Morris M, Wei J, Gorbounov M, Wei C. New technology and clinical applications of nanomedicine. Med Clin North Am 2007;91(5):845-62.58- Jain KK. Nanotechnology in clinical laboratory diagnostics. Clin Chim Acta 2005;358:37-54.59- Shiohara A, Hoshino A, Hanaki K, Suzuki K, Yamamoto K. On the cyto-toxicity caused by quantum dots. Microbiol Immunol 2004;48(9):669-75.60- Lovric J, Bazzi HS, Cuie Y, Fortin GR, Winnik FM, Maysinger D. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 2005;83:377-85.61- Saraceno R, Chiricozzi A, Gabellini M, Chimenti S. Emerging applications of nanomedicine in dermatology. Skin Res Technol 2013 Feb;19(1):e13-962- Ahmed, N et al. Theranostic applications of nanoparticles in câncer. Drug Discov Today 2012;17:928-34.63- Solanki A, Kim JD, Lee KB. Nanotechnology for regenerative medicine: nanomaterials for stem cells imaging. Nanomedicine (Lond). 2008;3:567-78.64- Wang MD, Shin DM, Simons JW, Nie S. Nanotechnology for targeted cancer therapy. Expert Rev Anticancer Ther 2007;7(6):833-7.65- Dickerson EB, Dreaden EC, Huang X, El-Sayed IH, Chu H, Pushpanketh S, et al.88. Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Lett 2008;269:57-66.66- Chatterjee DK, Fong LS, Zhang Y. Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev 2008;60:1627-37.67- Nasir A. Nanotechnology and dermatology: Part II—risks of nanotechnology. Clinics in Dermatology 2010:28;581–8.68- Araujo L, Lobenberg R, Kreuter J. Influence of the surfactant concentration on the body distribution of nanoparticles. J Drug Target 1999;6:373-85.67- Oberdörster G, Gelein RM, Ferin J, Weiss B. Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal Toxicol 1995;7:111-24.68. Oberdörster G, Sharp Z, Atudorei V, et al. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A 2002;65:1531-43.69. Oberdörster G. Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal Toxicol 1996;8:73-89.70- Mura S, Couvreur P. Nanotheranostics for personalized medicine, Adv Drug Deliv Rev 2012;64:1394-416.71- Subramaniam VD, Prasad SV, Banerjee A, Gopinath M, Murugesan R, Marotta F, Sun XF, Pathak S. Health hazards of nanoparticles: understanding the toxicity mechanism of nanosized ZnO in cosmetic products. Drug Chem Toxicol 2018;13:1-10.72- Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. Size dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 2001;175:191-9.73- Hetland RB, Cassee FR, Refsnes M, et al. Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol In Vitro 2004;18:203-12.