The Challenges of COVID-19 Treatment in Older Patients and Potential Drug Interactions

Yıl 2020, Cilt: 3 Sayı: 3, 81 - 83, 31.12.2020

Esra Ateş Bulut Pinar Soysal Ahmet Turan Işık

Öz

COVID-19 is a new Coronavirus disease that researchers have reported older age, male gender, and comorbidity are associated with a higher risk of severe disease and mortality. Unfortunately, there is no sufficient supporting evidence that any potential therapy improves outcomes in patients diagnosed with COVID-19. Currently, one of the most popular potential treatment options is hydroxychloroquine. However, it also has serious adverse effects (<10%), including QTc prolongation with a possible risk of torsades de pointes, hypoglycemia, neuropsychiatric effects, and retinopathy. Therefore, careful monitoring is required during hydroxychloroquine treatment, and there is an urgent need to develop safe and effective drugs to treat COVID-19 potentially.

Anahtar Kelimeler

COVID-19, drug interactions, hydroxychloroquine, older adults, polypharmacy

Proje Numarası

yok

Yaşlı COVID-19 Hastalarında Tedavinin Güçlükleri ve Potansiyel İlaç Etkileşimleri

Öz

COVID-19, araştırmaların ileri yaş, erkek cinsiyet ve komorbiditenin daha şiddetli hastalık ve ölüm riski ile ilişkili olduğunu bildirdiği yeni bir koronavirüs hastalığıdır. Ne yazık ki, herhangi bir potansiyel tedavinin COVID-19 teşhisi konan hastalarda sonuçları iyileştirdiğine dair yeterli destekleyici kanıt yoktur. Şu anda en popüler potansiyel tedavi seçeneklerinden biri hidroksiklorokindir. Ancak hidroksiklorokin, QTc uzaması ile birlikte olası torsades de pointes riski, hipoglisemi, nöropsikiyatrik etkiler, retinopati gibi ciddi yan etkilere (<% 10) neden olabilmektedir. Bu nedenle, hidroksiklorokin tedavisi sırasında dikkatli izlem gereklidir ve COVID-19'u tedavi etme potansiyeline sahip güvenli ve etkili ilaçların geliştirilmesine acil ihtiyaç duyulmaktadır.

Anahtar Kelimeler

yaşlı, COVID-19, İlaç etkileşimleri, hidroksiklorokin, polifarmasi

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

yok

Kaynakça

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