Endokrin Bozucu Kimyasallar ve Kanserojen Etkileri

Öz

Endokrin bozucu kimyasalların (EDC) karsinogenezdeki rolü, hormon bağımlı kanserlerde hormon sentezi, salınımı, taşınması, metabolizması ve reseptör aracılı sinyal iletim yollarına müdahale edilmesini kapsamaktadır. Giderek artan sayıda kanıt, EDC maruziyetinin epigenetik mekanizmalar aracılığıyla kanser gelişimini etkileyebileceğini ve bu etkinin uzun dönemli ve potansiyel olarak nesiller arası sonuçlara yol açabileceğini göstermektedir. Mevcut kanıtlar, EDC maruziyeti ile ilişkili kanser riskinin yalnızca maruziyetin varlığına değil, maruziyetin düzeyine, süresine ve özellikle maruziyetin gerçekleştiği gelişimsel döneme bağlı olarak belirlendiğini ortaya koymaktadır. Endokrin bozucu kimyasallar arasında, Uluslararası Kanser Araştırmaları Ajansı (IARC) tarafından Grup 1 insan kanserojeni olarak sınıflandırılan başlıca bileşikler 2,3,7,8-tetraklorodibenzo-p-dioksin (TCDD), poliklorlu bifeniller (PCB’ler) ve dietilstilbestroldür (DES). Gerçek yaşamda EDC maruziyeti genellikle çoklu bileşiklerin eşzamanlı maruziyetini içermekte olup, mekanistik ve epidemiyolojik verileri birleştiren translasyonel çalışmalara duyulan gereksinimi ortaya koymaktadır.

Anahtar Kelimeler

• Endokrin bozucu kimyasallar (EDC’ler)
• karsinogenezis
• hormon sentezi

Endocrine-Disrupting Chemicals and Their Carcinogenic Effects

Öz

The role of endocrine-disrupting chemicals (EDCs) in carcinogenesis is multifaceted, encompassing interference with hormone synthesis, secretion, transport, metabolism, and receptor-mediated signalling pathways in hormone-dependent cancers. Accumulating evidence indicates that exposure to EDCs may influence cancer development through epigenetic mechanisms, giving rise to long-term and potentially transgenerational effects. Current evidence suggests that cancer risk associated with EDC exposure is determined not only by the presence of exposure but also by the dose, duration, and, importantly, the developmental timing of exposure. Among endocrine-disrupting chemicals, those classified as Group 1 human carcinogens by the International Agency for Research on Cancer (IARC) include 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls (PCBs), and diethylstilbestrol (DES). In real-world settings, exposure to endocrine-disrupting chemicals typically involves simultaneous exposure to multiple compounds, highlighting the need for translational studies that integrate mechanistic and epidemiological evidence.

Anahtar Kelimeler

• ndocr"ne-d"srupt"ng chem"cals (EDCs)
• carc"nogenes"s

Kaynakça

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