Androgenetic Alopecia

Öz

Androgenetic alopecia (AGA), which is the most common type of alopecia, concerns both men and women. Although the pathogenesis is not clearly understood, it is thought that AGA develops in genetically susceptible individuals due to the influence of androgens. AGA, which is characterized by progressive loss of hair diameter, length, and pigmentation, affects men more severely and frequently, however its psychological and social impacts are more expansive in women. Despite the fact that there are several treatment options available for AGA, up to now therapeutic effects of drugs have been turned out to be only temporary.

Anahtar Kelimeler

• androgenetic alopecia,etiopathogenesis,classification,treatment

Androgenetik Alopesi

Öz

Alopesilerin en sık görülen tipi olan androgenetik alopesi (AGA), hem erkek hem de kadınları etkiler. Patogenezi henüz tüm yönleriyle aydınlanamamış olmakla beraber, AGA’nın genetik yatkınlığa sahip bireylerde androjenik etkiyle geliştiği düşünülmektedir. Saçların çap, uzunluk ve renginde ilerleyici kayıpla karakterize olan hastalığın şiddeti ve sıklığı erkeklerde, psikolojik ve sosyal etkileri ise kadınlarda daha fazladır. AGA’nın tedavisinde çok sayıda seçenek bulunmasına karşın, şimdiye kadar kullanılan ilaçların etkinlikleri genellikle geçici olmaktan öteye gidememiştir.

Anahtar Kelimeler

• androgenetik alopesi,etyopatogenez,sınıflama,tedavi

Kaynakça

1. Bienová M, Kucerová R, Fiurásková M, Hajdşch M, Koláŕ Z. Androgenetic alopecia and current methods of treatment. Acta Dermatovenerol Alp Panonica Adriat 2005;14(1):5-8.
2. Şendur N, Karaman G. Androgenetik Alopesi. ADÜ Tıp Fakültesi Dergisi 2000;1(3):39–46.
3. Bergfeld WF. Androgenetic alopecia: an autosomal dominant disorder. Am J Med 1995;98(1A):95S-98S.
4. Borlu M, Ukşal Ü, Utaş S, Bayram F, Müderris İ. Androgenetik Alopesili 59 Kad?n Hastada Hiperandrojenizm ve Polikistik Over Sendromu. Türkderm 2004;38(2):106-110.
5. Küster W, Happle R. The inheritance of common baldness: two B or not two B? J Am Acad Dermatol ;11(5 Pt 1):921-6. Hamilton JB. Patterned loss of hair in man; types and incidence. Ann NY Acad Sci 1951; 53:708-28.
6. Olsen EA. Androgenetic alopecia. In: Olsen EA, ed. Disorders of Hair Growth. 1st ed. New York: McGraw- Hill;1994. p.257-83.
7. Thomas J. Androgenetic alopecia - Current status.Indian J Dermatol 2005;50:179-190.
8. Dinh QQ, Sinclair R. Female pattern hair loss: current treatment ;2(2):189-99. Clin Interv Aging Gan DC, Sinclair RD. Prevalence of male and female pattern hair loss in Maryborough. J Investig Dermatol Symp Proc 2005;10(3):184-9.

9. Norwood OT. Incidence of female androgenetic alopecia (female pattern alopecia). Dermatol Surg ;27(1):53-4. Yip L, Rufaut N, Sinclair R. Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: an update of what we now know. Australas J Dermatol 2011;52(2):81-8.
10. Uemura M, Tamura K, Chung S, et al. Novel 5 alpha- steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci ;99(1):81-6. Niiyama S, Happle R, Hoffmann R. Influence of estrogens on the androgen metabolism in different subunits of human hair follicles. Eur J Dermatol ;11(3):195-8. Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975;68: 1359–65.
11. Ludwig E. Classification of the androgenetic alopecia (common baldness) occuring in the females sex. Br J Dermatol 1977;97:247.
12. Mohungoo MJ, Messenger AG. Female Pattern Hair Loss. In: Trüeb RM, Tobin DJ, eds. Aging Hair. st ed. Berlin: Springer;2010.p.41-48.
13. Dhurat R. Phototrichogram. Indian J Dermatol Venereol Leprol 2006;72 (3):242- 4.
14. Rivera R, Guerra-Tapia A. [Management of androgenetic alopecia in postmenopausal women]. Actas Dermosifiliogr 2008;99(4): 257-61.
15. Carmina E, Lobo RA.Treatment of hyperandrogenic alopecia in women.Fertil Steril 2003;79(1):91-5.