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Öz

Aim Obstructive sleep apnea is a highly prevalent disease, affecting 4% of adult in western countries. Heart rate variability is decreased in obstructive sleep apnea patients, and it is associated with poor cardiovascular outcome. We aimed to evaluate autonomic function in obstructive sleep apnea patients with heart rate variability. Material and Method We selected 30 obstructive sleep apnea patients without comorbidity and 30 healthy individual. All patients underwent 24 hours holter monitoring to assess heart rate variability. Results Age and gender were not different in two groups. Body mass index was higher in obstructive sleep apnea patients compared to the control group (36.43±6.8 and 27.21±36.4, p=0.001 respectively). SDNN was lower in obstructive sleep apnea patients than the control group (128.73±31.27 and 144.80±37.74, p=0.021 respectively). LF and LF/HF value were higher in patients with obstructive sleep apnea compared to those with control (680.76±319.47 vs. 524.87±348.78, p=0.02 and 4.745±2.16 vs. 2.9583±1.79, p=0.001 respectively). HF was lower in obstructive sleep apnea patients compared to control group (238.00±96.07 and 167.57±75.09, p=0.007 respectively). Conclusion We detected reduced heart rate variability and impaired balance between sympathetic-parasympathetic systems in OSAS patients. OSAS patients should be closely followed for developing arrhythmias.

Anahtar Kelimeler

• Obstructive sleep apnea, Heart rate variability, Arrhythmia

Uyku Apne Sendromlu Hastalarda Otonomik Fonksiyonların Değerlendirilmesi

Öz

Amaç Uyku apne sendromu toplumda yaygın olarak görülen ve batı ülkelerindeki yetişkinlerin %5’ni etkileyen bir bozukluktur. Uyku apne sendromu olan hastalarda kalp hızı değişkenliğinin azaldığı ve olumsuz kardiyovasküler sonuçlarla ilişkili olduğu saptanmıştır. Biz bu çalışmamızda uyku apne sendromu olan hastalarda otonomik fonksiyon değerlendirmesini zaman ve frekans temelli kalp hızı değişkenliği yöntemi ile değerlendirmeyi amaçladık.

Gereç ve Yöntem Çalışmaya uyku apne sendromu tanısı alan ve ek hastalığı olmayan 30 hasta ve sağlıklı 30 kişi alındı. Hastalar uyku apne sendromu ve kontrol grubu olarak iki sınıfa ayrıldı. Tüm hastalar, kalp hızı değişkenliğini değerlendirmek üzere 24 saatlik holter kaydı altına alındı.

Bulgular Hastaların yaş ve cinsiyeti açısından aralarında istatiksel fark saptanmadı. Uyku apne sendromu grubunda vücut kitle indeksi kontrol grubuna göre yüksek olarak saptandı (36.43±6.8 ve 27.21±36.4, p=0.001 sırasıyla). SDNN değeri uyku apne sendromu grubunda sağlıklı gruba göre düşük olarak saptandı (128.73±31.27 ve 144.80±37.74, p=0.021). Frekans temelli değerlerden LF ve LF/HF, uyku apne sendromlu hastalarda kontrol grubuna göre yüksek saptandı (680.76±319.47&524.87±348.78, p=0.02 ve 4.745±2.16&2.95±1.79, p=0.001 sırasıyla). HF değeri uyku apne sendromu hastalarda kontrol grubuna göre düşük olarak saptandı (238.00±96.07 ve 167.57±75.09, p=0.007)

Sonuç Uyku apne sendromu olan hastalarda kalp hızı değişkenliğinde azalma ve sempatik ve parasempatik sistem arasındaki dengenin bozulduğunu saptadık. Uyku apne sendromu olan hastalar gelişebilecek kardiyak aritmiler yönünden dikkatlice değerlendirilmelidir.

 

Anahtar Kelimeler Uyku apne sendromu, Kalp hızı değişkenliği, Aritmi

Anahtar Kelimeler

• Uyku apne sendromu, Kalp hızı değişkenliği, Aritmi

Kaynakça

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