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Öz

Objective: The aim of this study was to evaluate the findings of second trimester fetal anatomic ultrasound scan in pregnant women with high level Alpha Feto Protein (AFP) in triple test. Methods: Triple test results of 8552 pregnant women were evaluated in a university hospital between January 2011 and December 2013. Fetal anatomic ultrasound scan results of pregnant women who had AFP level ≥2.5 multiples of median (MoM) in triple test were investigated for presence of pathologic findings. Results: AFP levels were detected over 2.5 MoM in 122 (1.14%) of 8552 pregnant women. There were no pathologic findings in 85.2% (104/122) of cases, but 14.8% (18/122) of cases had pathologic results; neural tube defect (NTD) 9% (11/122) and anhidroamnios 2.5% (3/122). Omphalocele, polycystic kidney, sacrococcygeal teratoma, placental chorangioma were detected in 0.8% ratio. NTDs were found in 11 (0.12%) of 8552 pregnant women who evaluated for maternal serum AFP (MSAFP). Conclusion: The routine use of MSAFP may be queried in NTD screening due to common usage of sufficient fetal anatomic ultrasound scan

Anahtar Kelimeler

• Alpha feto protein, neural tube defects, ultrasound, anomaly

İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları

Öz

Amaç: Bu çalışmanın amacı üçlü testte Alfa Feto Protein (AFP) yüksekliği saptanan gebelerde ikinci trimester ayrıntılı ultrasonografi bulgularının irdelenmesidir.

Yöntem: Ocak 2011 - Aralık 2013 tarihleri arasında bir üniversite hastanesi gebe polikliniğinde üçlü test yapılan 8552 gebenin test sonuçları değerlendirildi. Üçlü test sonucunda AFP değeri ≥2.5 multiples of median (MoM) çıkan gebelerin ikinci düzey (ayrıntılı) ultrasonografi sonuçları patolojik bulguların varlığı açısından değerlendirildi.

Bulgular: Değerlendirmeye alınan 8552 gebenin 122(%1.14)'sinde AFP değeri 2.5 MoM üzerinde saptandı. İkinci düzey ultrasonografide olguların %85.2 (104/122)'inde patoloji saptanmazken %14.8 (18/122)'sinde patolojik bulgu tespit edildi; %9 (11/122)'sinde nöral tüp defekti (NTD) (Chiary tip-II) ve %2.5 (3/122)'sinde anhidroamnios saptandı. Omfalosel, polikistik böbrek, sakrokoksigeal teratom ve plasental koranjioma ise %0.8 oranında saptandı. Maternal serum AFP (MSAFP) değerlendirilmesi yapılan 8552 gebenin 11'inde (%0.12) NTD saptandı.

Sonuç: Yeterli ultrasonografik anatomik incelemenin yaygın olarak yapılması nedeniyle fetal NTD taramasında MSAFP'nin rutin kullanımı sorgulanabilir.

 

Anahtar Kelimeler

• Alfa feto protein, nöral tüp defekti, ultrasonografi, anomali

Kaynakça

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