Obesity in Childhood Acute Lymphoblastic Leukemia Survivors: A Literature Review

Öz

Purpose: Obesity is one of the most important late effects that seen in survivors of childhood acute lymphoblastic leukemia. In this literature review, it is aimed to determine frequency of obesity in survivors of childhood acute lymphoblastic leukemia and characteristics of survivors.

Materials and Methods: Review of the literature was made on Pubmed and Wiley Interscience and 13 studies were examined that conducted between 2003 and 2013.

Results: Frequency of obesity in survivors is between 4.6% and 38.2%. The prevalence of obesity showed increases in female and survivors treated high dose cranial radiation therapy and survivors with long-term steroid exposure.

Conclusion: It was shown that obesity is the most common late effects in survivors and there has been many late effects such as growth and development problems, cardiac anomalies, hypertension with obesity.

 

Anahtar Kelimeler

• Child, Leukemia, Survivor, Obesity

Çocukluk Çağı Akut Lenfoblastik Lösemi Sağ Kalanlarında Obezite: Bir Literatür Taraması

Öz

Amaç: Obezite, akut lenfoblastik lösemi tanısı sonrası sağkalan çocuklarda görülen en önemli geç yan etkiler arasındadır. Yapılan bu literatür derlemesinde, çocukluk çağı akut lenfoblastik lösemisinden sağkalanlarda obezite görülme sıklığının ve sağkalanların özelliklerinin belirlenmesi amaçlanmıştır.

Materyal ve Metot: Pubmed ve Wiley Interscience veri tabanları taranarak 2003-2013 yılları arasında yapılmış 13 çalışma incelenmiştir.

Bulgular: İncelenen çalışmalarda çocuklarda obezite görülme sıklığının %4.6 ile %38.2 arasında değiştiği belirlenmiştir. Yüksek doz kranial radyoterapi alanlarda, uzun süreli steroid maruziyeti olanlarda ve kız çocuklarında obezite prevalansında artış saptanmıştır.

Sonuç: Obezitenin, sağkalanlarda en yaygın geç etkilerden olduğu ve obezite ile beraber büyüme gelişme problemleri, kardiak anomaliler ve hipertansiyon gibi birçok yan etkinin görüldüğü belirlenmiştir.

Anahtar Kelimeler: 

Anahtar Kelimeler

• Çocuk, Lösemi, Sağkalan, Obezite

Kaynakça

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