An unusual organ involvement in a case of Werner Syndrome: thyroid atrophy

Öz

Werner Syndrome (WS) is a premature aging disease that begins in adolescence or early adulthood and results in the appearance of old age by 30-40 years of age. Some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. In this article, we present a nineteen years-old female patient who had been diagnosed as WS two years ago because of type 2 diabetes mellitus, osteopenia, hyperlipidemia, cataract, gray hair, and skin atrophy. Subclinical hypothyroidism was detected at her laboratory tests. Thyroid ultrasonography (USG)  showed thyroid atrophy. Fine needle aspiration biopsy of both lobes  confirmed this diagnose and excluded some infiltrative diseases such as amyloidosis. It should be kept in mind that thyroid atrophy could be seen in WS and, therefore, detailed thyroid examination including thyroid USG and close follow up should be performed in all patients with WS.

 

Anahtar Kelimeler

• atrophy; thyroid; Werner syndrome

Werner Sendromlu bir olguda sıradışı organ tutulumu: tiroid atrofisi

Öz

Werner Sendromu (WS) adölesan veya erken erişkin döneminde başlayan erken yaşlanmaya neden olan bir hastalıktır. Hastalar 30-40 yaşlarında yaşlı insan görünümündedirler. Bu nadir görülen hastalıkta, hipogonadizm, diabetes mellitus ve hiperlipidemi gibi bazı endokrinolojik anormallikler de olabilmektedir. Biz bu yazıda tip 2 diabetes mellitus, osteopeni, hiperlipidemi, katarakt, gri saç ve cilt atrofisi nedeniyle iki yıldır WS tanısı ile takip edilen 19 yaşında bir bayan hasta sunduk. Hastanın yapılan labotaruvar testlerinde subklinik hipotiroidi saptandı. Tiroid ultrasonografisinde (USG) tiroidin atrofik boyutlarda olduğu gözlendi. Her iki lobdan yapılan tiroid ince iğne aspirasyonu sonucu da atrofi ile uyumlu idi ve amiloidozis gibi bazı infiltratif hastalıklar dışlandı. WS’unda tiroid atrofisinin olabileceği akılda tutulmalıdır. Bu yüzden tüm WS’lu hastalarda tiroid USG’yi de içeren detaylı tiroid muayenesi yapılmalı ve bu açıdan yakın takip edilmelidir.

 

Anahtar Kelimeler

• atrofi; tiroid; Werner Sendromu

Kaynakça

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